Stimuli Responsive Scaffolds Based on Carboxymethyl Starch and Poly(2‐Dimethylaminoethyl Methacrylate) for Anti‐Inflammatory Drug Delivery

Niţă, Loredana E.; Chiriac, Aurica P.; Rusu, Alina Gabriela; Ghilan, Alina; Dumitriu, Raluca Petronela; Bercea, Maria; Tudorachi, Niță

doi:10.1002/mabi.201900412

Cited by 25 publications

(14 citation statements)

References 37 publications

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“…The values of G’ are correlated with the network strength [ 35 , 36 , 37 ]. From Figure 5 and Figure 6 it can be observed that Lys content in the sample influences considerably the gel strength.…”

Section: Resultsmentioning

confidence: 99%

“…The morphological characterization of hydrogels by SEM analysis provides essential information on the size, shape and distribution of pores in their three-dimensional matrix [38]. The The values of G' are correlated with the network strength [35][36][37]. From Figures 5 and 6 it can be observed that Lys content in the sample influences considerably the gel strength.…”

Section: Sem Microscopymentioning

confidence: 99%

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New Physical Hydrogels Based on Co-Assembling of FMOC–Amino Acids

Croitoriu¹,

Niţă²,

Chiriac³

et al. 2021

Gels

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In the last years, physical hydrogels have been widely studied due to the characteristics of these structures, respectively the non-covalent interactions and the absence of other necessary components for the cross-linking processes. Low molecular weight gelators are a class of small molecules which form higher ordered structures through hydrogen bonding and π–π interactions. In this context it is known that the formation of hydrogels based on FMOC–amino acids is determined by the primary structures of amino acids and the secondary structure arrangement (alpha–helix or beta–sheet motifs). The present study aimed to obtain supramolecular gels through co-assembly phenomenon using FMOC–amino acids as low molecular weight gelators. The stability of the new structures was evaluated by the vial inversion test, while FTIR spectra put into evidence the interaction between the compounds. The gel-like structure is evidenced by viscoelastic parameters in oscillatory shear conditions. SEM microscopy was used to obtain the visual insight into the morphology of the physical hydrogel network while DLS measurements highlighted the sol-gel transition. The molecular arrangement of gels was determined by circular dichroism, fluorescence and UV-Vis spectroscopy.

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Section: Resultsmentioning

confidence: 99%

Section: Sem Microscopymentioning

confidence: 99%

New Physical Hydrogels Based on Co-Assembling of FMOC–Amino Acids

Croitoriu¹,

Niţă²,

Chiriac³

et al. 2021

Gels

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“…Swelling ratios of the porous NGHH from 25 to 51 °C for 24 h were determined gravimetrically ( Figure 7 a). The swelling ratios of these NGHH were not remarkable, which was attributed to the relatively high degree of cross-linking [ 44 ]. An approximately linear drop in swelling ratio occurred from 31 to 37 °C, indicating that the LCST of PNIPAAm is affected by the hydrogen bonding interaction with bovine skin gelatin.…”

Section: Resultsmentioning

confidence: 99%

Thermo-Tunable Pores and Antibiotic Gating Properties of Bovine Skin Gelatin Gels Prepared with Poly(n-isopropylacrylamide) Network

et al. 2020

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Polystyrene nanospheres (PNs) were embedded in bovine skin gelatin gels with a poly(N-isopropylacrylamide) (PNIPAAm) network, which were denoted as NGHHs, to generate thermoresponsive behavior. When 265 nm PNs were exploited to generate the pores, bovine skin gelatin extended to completely occupy the pores left by PNs below the lower critical solution temperature (LCST), forming a pore-less structure. Contrarily, above the LCST, the collapse of hydrogen bonding between bovine skin gelatin and PNIPAAm occurred, resulting in pores in the NGHH. The behavior of pore closing and opening below and above the LCST, respectively, indicates the excellent drug gating efficiency. Amoxicillin (AMX) was loaded into the NGHHs as smart antibiotic gating due to the pore closing and opening behavior. Accordingly, E. coli. and S. aureus were exploited to test the bacteria inhibition ratio (BIR) of the AMX-loaded NGHHs. BIRs of NGHH without pores were 48% to 46.7% at 25 and 37 °C, respectively, for E. coli during 12 h of incubation time. The BIRs of nanoporous NGHH could be enhanced from 61.5% to 90.4% providing a smart antibiotic gate of bovine skin gelatin gels against inflammation from infection or injury inflammation.

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“…Stimuli-responsive drug delivery system was also developed by Nita et al, [143] who prepared semi-interpenetrating polymer network hydrogels of carboxymethyl starch and poly(2dimethylaminoethyl methacrylate) loaded with ibuprofen. The hydrogels demonstrated pH and temperature responsiveness.…”

Section: Anti-inflammatory Architectures Based On Molecular Complexesmentioning

confidence: 99%

“…Nita et al 2020 [ 143] surface coatings. The researchers covalently immobilized poly(ethyl acrylate-co-methacrylic acid) microgels loaded with human heparin cofactor II-derived peptide KYE28 (KYEITTI-HNLFRKLTHRLFRRNFGYTLR), as well as its poly(ethylene glycol)-conjugated (PEGylated) version, KYE28PEG.…”

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confidence: 99%

Recent Advances in Antiinflammatory Material Design

Lebaudy

Fournel

Lavalle

et al. 2020

Adv Healthcare Materials

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Implants and prostheses are widely used to replace damaged tissues or to treat various diseases. However, besides the risk of bacterial or fungal infection, an inflammatory response usually occurs. Here, recent progress in the field of anti‐inflammatory biomaterials is described. Different materials and approaches are used to decrease the inflammatory response, including hydrogels, nanoparticles, implant surface coating by polymers, and a variety of systems for anti‐inflammatory drug delivery. Complex multifunctional systems dealing with inflammation, microbial infection, bone regeneration, or angiogenesis are also described. New promising stimuli‐responsive systems, such as pH‐ and temperature‐responsive materials, are also being developed that would enable an “intelligent” antiinflammatory response when the inflammation occurs. Together, different approaches hold promise for creation of novel multifunctional smart materials allowing better implant integration and tissue regeneration.

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Stimuli Responsive Scaffolds Based on Carboxymethyl Starch and Poly(2‐Dimethylaminoethyl Methacrylate) for Anti‐Inflammatory Drug Delivery

Cited by 25 publications

References 37 publications

New Physical Hydrogels Based on Co-Assembling of FMOC–Amino Acids

New Physical Hydrogels Based on Co-Assembling of FMOC–Amino Acids

Thermo-Tunable Pores and Antibiotic Gating Properties of Bovine Skin Gelatin Gels Prepared with Poly(n-isopropylacrylamide) Network

Recent Advances in Antiinflammatory Material Design

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