A novel triazine-aryl-bis-indole derivative inhibits both phosphodiesterase IV and expression of cell adhesion molecules

Abstract

Triazine-aryl-bis-indole derivative inhibits phosphodiesterase activity.

Molecular Organization in Crystals of Bis(diaminotriazinyl)-Substituted Derivatives of Benzene, Pyridine, and Pyrazine

“…Aryltriazines play key roles in many different areas of chemistry. Derivatives are noted for their biological activity, − as well as for their ability to self-associate and to serve as subunits for modular supramolecular construction. − Of special interest are compounds that incorporate 4,6-diamino-1,3,5-triazinyl (DAT) groups, which feature multiple sites able to engage in hydrogen bonding. The DAT group can thereby self-associate according to standard motifs I – III , which differ only in the relative orientation of the substituent at C-2 .…”

Novel Synthesis of Imidazo‐based and Benzimidazo‐based privileged Templates on s‐Triazine Nucleus through a Phenoxyl Spacer

“…Considering the immensely rich diverse biological properties of s ‐triazine , imidazoles , and benzimidazoles , it was found of paramount interest to incorporate all these biologically active privileged pharmacophores into a single molecular framework by utilizing the reactivity of an active synthon imidate ester (Fig. ).…”

Design, synthesis and characterization of [1,3,4]thiadiazolo- and [1,2,4]oxadiazolo- substituted 2,4-dicyclopropylamino-6-phenoxy-s-triazines

“…1,3,5-Triazine is an important heterocycle and has gained much synthetic popularity due to its broad spectrum of biological properties such as antimicrobial, 1 anticancer, 1 antimalarial, 1 antiviral, 1 antimycobacterial, 1 antibacterial, 1 antiprotozoal, 2 antifungal, 3 anti-trypanosomal, 4 VLA-4 integrin antagonists, 5 cytotoxic, 6 herbicidal, 7 anticonvulsant, 8 anti-inflammatory, 8 analgesic, 9 acetylcholinesterase inhibitors, 10 antiasthamatic 11 and dihydrofolate reductase inhibitors. 12 Recent studies, based on the s-triazine scaffold showing anti-tumour 13 and anti-HIV 14 activity have led these to be considered as most promising molecule to be employed as lead structures in the discovery of newer medicinally potent chemotherapeutic agents.…”