Novel Synthesis of Imidazo‐based and Benzimidazo‐based privileged Templates on s‐Triazine Nucleus through a Phenoxyl Spacer

Abstract

A novel synthetic procedure has been designed for the synthesis of imidazo‐based and benzimidazo‐based privileged templates on s‐triazine nucleus through a phenoxyl spacer by exploiting the versatility of the reactive synthon imidate ester.

Green advancements towards the electrochemical synthesis of heterocycles

“…This approach can effectively circumvent the use of hydrazine chemicals, as it is used in many of the synthetic procedures for the incorporation of pyrazole ring in the hybrid multicomponent drug synthesis. [23][24][25] They have been shown to have substantial toxicity or carcinogenic qualities.…”

Green Synthesis of 1,2,4,5‐Tetrasubstituted and 2,4,5‐Trisubstituted Imidazole Derivatives Involving One‐pot Multicomponent Reaction

“…The synthesis of 1,2,4,5‐tetrasubstituted imidazoles is carried out by four‐component cyclo‐condensation of a 1,2‐diketone/hydroxyketone with various aldehydes, primary amine, and ammonium acetate with molecular SBA‐15 mesoporous and 2,2,2‐trifluoroethanol (SBA‐15/TFE) , clay‐supported titanium and using as a catalyst. 2,4,5‐Trisubstituted imidazole derivatives are generally synthesized by three‐component condensation of a 1,2‐diketone/hydroxyketone with various aldehydes and ammonium acetate, zeolite HY with silica gel , ZrO(NO 3 ) 2 .XH 2 O , ZrO 2 ‐supported β‐cyclodextrin (ZrO 2 ‐β‐CD) , cerric ammonium nitrate (CAN) , 2,6‐dimethylpyridiniumtrinitromethanide {[2,6‐DMPyH]C(NO 2 ) 3 } , nano copperferrite , poly(4‐vinylpyridinium butane sulfonic acid) hydrogen sulfate , ZSM‐5‐SO 3 H , zinc acetate , N ‐bromosuccinimide , 2‐ethylhexanoic acid , tritylchloride (TrCl or Ph 3 CCl) , silica chloride , zeolite, nano‐crystalline sulfated zirconia ' NH 4 Fe(SO 4 ) 2 KOH , Phenoxyl Spacer , and nanocrystalline silica supported tin oxide (SiO 2 :SnO 2 ) as catalyst.…”