A novel transdermal patch incorporating isosorbide dinitrate with bisoprolol: In vitro and in vivo characterization

Zhao, Jihui; Fu, Jihua; Wang, Shuming; Su, Chang-Hai; Ying, Shao‐Yao; Kong, Shu-Jia; Wang, Yuan; Lü, Wan-Liang; Zhang, Hua; Zhang, Shuang; Li, Lin; Zhang, En-Hong; Wang, L i; Pei, Qiu-Ling; Wang, Jiancheng; Zhang, Xuan; Zhang, Qiang

doi:10.1016/j.ijpharm.2006.12.030

Cited by 24 publications

(15 citation statements)

References 24 publications

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“…Thus, the receptor media volume was nine times greater than the saturation point and the sink conditions were achieved during the permeation experiment. In fact, other researchers also used water as the receptor media for the purpose of simulating a human physiological environment (Zhao et al, 2007).…”

Section: Evaluation Of Sink Conditionsmentioning

confidence: 99%

“…Zhao et al (2007) developed single-layer drug-in-adhesive transdermal patches, in which the adhesive layer not only serves as an adhesion layer to the skin, but also is responsible for the release of the drug. The in vitro release results show that the release kinetics of ISDN is a first-order process, suggesting that the outwards moving of ISDN from the adhesive is associated with a passive diffusion process.…”

Section: Introductionmentioning

confidence: 99%

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Formulation and evaluation of transdermal drug-delivery system of isosorbide dinitrate

Zhan

Mao

Chen

et al. 2015

Braz. J. Pharm. Sci.

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The purpose of this study was to develop a reservoir-type transdermal delivery system for isosorbide dinitrate (ISDN). The developed patch consisted of five layers from bottom to top, namely, a temporary liner, an adhesive layer, a rate-controlling membrane, a reservoir and a backing. The effects of chemical penetration enhancers, reservoir materials and rate-controlling membranes on the release behaviour of ISDN from the transdermal patch were studied, and the in vitro release of ISDN from the developed patch was studied and compared with the commercially available ISDN patch. The results showed that there was no significant difference in permeation rates between the developed reservoir-type patch and the commercially available ISDN patch (p > 0.05). Moreover, the cumulative release ratio of the commercially available ISDN patch in 48 h was up to 89.8%, whereas the developed patch was only 34.9%, which meant the sustained release time of the developed patch was much longer than the commercially available ISDN patch, and would promote the satisfaction of the patient. Uniterms:Isosorbide dinitrate/transdermal drug-delivery system. Transdermal patches/in vitro release. Transdermal patches/sustained release. Controlling membrane/drugs release rate. Skin penetration/ drugs release.O objetivo do presente estudo foi desenvolver um sistema de liberação transdérmico do tipo reservatório para o dinitrato de isossorbida (ISDN, abrevitura em Inglês). A formulação transdérmica desenvolvida constou de cinco camadas de baixo para cima, ou seja, um revestimento temporário, uma camada adesiva, uma membrana controladora da taxa de liberação, um reservatório e um reforço. Estudaram-se os efeitos dos potenciadores de penetração química, materiais do reservatório e membranas de controle da taxa de liberação no comportamento da formulação transdérmica de dinitrato de isossorbida. A liberação in vitro da formulação transdérmica de dinitrato de isossorbida desenvolvida foi estudada em comparação com a formulação de dinitrato de isossorbida disponível comercialmente. Os resultados mostraram que não existem diferenças significativa nas taxas de permeação entre o tipo de reservatório desenvolvido e o de dinitrato de isossorbida desenvolvido comercialmente (p>0,05). Ademais, a taxa de liberação cumulativa da formulação de dinitrato de isossorbida disponível comercialmente em 48 horas foi de até 89,8% e a da formulação desenvolvida, de apenas de 34,9%, o que provou que a liberação sustentada da formulação desenvolvida foi muito maior do que a de dinitrato de isossorbida desenvolvida comercialmente, o que promoveria a satisfação do paciente.

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Section: Evaluation Of Sink Conditionsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Formulation and evaluation of transdermal drug-delivery system of isosorbide dinitrate

Zhan

Mao

Chen

et al. 2015

Braz. J. Pharm. Sci.

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“…The number of times the film could be folded at the same place without breaking was consider as folding endurance value 11,12,13 .…”

Section: Folding Endurancementioning

confidence: 99%

Formulation and in-Vitro Evaluation of Transdermal Films of an Anti Hypertensive Drug

Reddy¹,

Rajashekar²,

Jayanthi³

et al. 2013

Int. Res. J. Pharm.

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In the present study was made to develop a suitable matrix type transdermal patch of Candesartan Cilexetil, using blends of two different types of polymeric combinations viz. HPMC K100 and Eudragit RL100 prepared formulations were subjected to various physiochemical evaluation tests like moisture content loss, moisture absorption, flatness to study the stability of the formulations, in vitro dissolution was performed to determine the amount of Candesartan present in the patches. Drug excipient interaction studies were carried out using Fourier transform infrared (FTIR) spectroscopy technique. The in vitro release of the drug from the formulations was studied using commercial semi permeable membrane. All the formulations were found to be suitable for formulating in terms of physiochemical characteristics and there was no notification in significant interaction between the drug and polymer used. In vitro dissolution data showed that formulation of F11 showed faster release of drug than the F14 formulations during dissolution studies. Skin irritation studies revealed that the batch containing HPMCK100-Eudragit RL100 has no erythema and edema. Based on the observation, we can reveal that HPMCK100-eudragit RL100 polymers are better suited for the development of Candesartan cilexetil transdermal patches.

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“…Some of them are based on the monitoring of the effects of penetrating agents. In these models, pathological conditions are induced, for example, renovascular hypertension [8] or pain [9], and amelioration of the disorder is considered proof of effective penetration. In other models, the presence of the drug in the skin is revealed or its impact on the structure or on certain functions of the skin is demonstrated.…”

Section: Introductionmentioning

confidence: 99%

A Novel Murine Model for theIn VivoStudy of Transdermal Drug Penetration

Erős

Hartmann

Berkó

et al. 2012

The Scientific World Journal

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Enhancement of the transdermal penetration of different active agents is an important research goal. Our aim was to establish a novel in vivo experimental model which provides a possibility for exact measurement of the quantity of penetrated drug. The experiments were performed on SKH-1 hairless mice. A skin fold in the dorsal region was fixed with two fenestrated titanium plates. A circular wound was made on one side of the skin fold. A metal cylinder with phosphate buffer was fixed into the window of the titanium plate. The concentration of penetrated drug was measured in the buffer. The skin fold was morphologically intact and had a healthy microcirculation. The drug appeared in the acceptor buffer after 30 min, and its concentration exhibited a continuous increase. The presence of ibuprofen was also detected in the plasma. In conclusion, this model allows an exact in vivo study of drug penetration and absorption.

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A novel transdermal patch incorporating isosorbide dinitrate with bisoprolol: In vitro and in vivo characterization

Cited by 24 publications

References 24 publications

Formulation and evaluation of transdermal drug-delivery system of isosorbide dinitrate

Formulation and evaluation of transdermal drug-delivery system of isosorbide dinitrate

Formulation and in-Vitro Evaluation of Transdermal Films of an Anti Hypertensive Drug

A Novel Murine Model for theIn VivoStudy of Transdermal Drug Penetration

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