Tramadol hydrochloride is a synthetic opioid used as a centrally acting analgesic and effective in both experimental and clinical pain. The half-life of the drug is about 5.5 hours and oral dose is 50 to 100 mg every 4 to 6 hours. To reduce the frequency of administration and to improve patient compliance, a sustained-release formulation of tramadol is desirable. The directly compressible floating tablets of Tramadol HCl were formulated using varying amounts of carbopol-934, HPMC K100M, and Hibiscus rosa-sinensis polymers along with other requisite excipients. Sodium bicarbonate was incorporated as a gas-generating agent. The concentration of the polymers increased gradually to attain the optimised formulation. In-vitro drug release profile and floatational characteristics of the formulations were determined. The studies indicated successful formulation of gastroretentive compressed matrices with excellent sustained release and hydrodynamic balance. From FTIR studies no interaction was found between the Tramadol HCl and polymers. Comparison of the dissolution profiles of the optimized formulation, with optimal composition of HPMC: Hibiscus rosa sinensis; 100:100, with that of marketed formulation indicated analogy of drug release performance with each other. The optimized formulation F10 was found to exhibit first–order kinetics which shows the diffusion along with polymer relaxation and polymer erosion of drug from the tablet
In the present study was made to develop a suitable matrix type transdermal patch of Candesartan Cilexetil, using blends of two different types of polymeric combinations viz. HPMC K100 and Eudragit RL100 prepared formulations were subjected to various physiochemical evaluation tests like moisture content loss, moisture absorption, flatness to study the stability of the formulations, in vitro dissolution was performed to determine the amount of Candesartan present in the patches. Drug excipient interaction studies were carried out using Fourier transform infrared (FTIR) spectroscopy technique. The in vitro release of the drug from the formulations was studied using commercial semi permeable membrane. All the formulations were found to be suitable for formulating in terms of physiochemical characteristics and there was no notification in significant interaction between the drug and polymer used. In vitro dissolution data showed that formulation of F11 showed faster release of drug than the F14 formulations during dissolution studies. Skin irritation studies revealed that the batch containing HPMCK100-Eudragit RL100 has no erythema and edema. Based on the observation, we can reveal that HPMCK100-eudragit RL100 polymers are better suited for the development of Candesartan cilexetil transdermal patches.
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