Formulation and evaluation of transdermal drug-delivery system of isosorbide dinitrate

Zhan, Xiaoping; Mao, Zhuo; Chen, Sijing; Chen, Shaoxiong; Wang, Liqun

doi:10.1590/s1984-82502015000200015

Cited by 12 publications

(3 citation statements)

References 17 publications

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“…(C n ) and (C col ) are the concentration of drug in the receptor compartment and the concentration of drug in the sample, respectively. (V R ) and (V i ) are the receptor compartment volume and the sample volume, respectively [ 39 ].

where S = 3.14 cm 2 and V R = 20 mL.…”

Section: Methodsmentioning

confidence: 99%

Preparation and Evaluation of Vitamin D3 Supplementation as Transdermal Film-Forming Solution

Kittaneh

Qurt

Malkieh³

et al. 2022

Pharmaceutics

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Vitamin D3 is available in oral and injectable dosage forms. Interest in the transdermal route as an alternative to the oral and parenteral routes has grown recently. In this study, several film-forming solutions for the transdermal delivery of vitamin D3 were prepared. They contained 6000 IU/mL of vitamin D3 that formed a dry and acceptable film in less than 5 min after application. The formulations consisted of ethanol and acetone 80:20, and one or more of the following ingredients: Eudragit L100-55, PVP, PG, limonene, oleic acid, camphor, and menthol. Vitamin D3 release was studied from both the film-forming solution and pre-dried films using a Franz diffusion cell. The film-forming solution released a significant amount of vitamin D3 compared to the dry film, which is attributed mostly to the saturation driving force due to the evaporation of volatile solvents. In vitro permeation studies through artificial skin Strat M® membrane revealed that the cumulative amount of vitamin D3 permeated after 24 h under the experimental conditions was around 800 IU across 3.14 cm2. The cumulative permeation curve showed faster permeation in earlier stages. Young’s modulus, viscosity, and pH of the formulations were determined. Most of the formulations were stable for 3 weeks.

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where S = 3.14 cm 2 and V R = 20 mL.…”

Section: Methodsmentioning

confidence: 99%

Preparation and Evaluation of Vitamin D3 Supplementation as Transdermal Film-Forming Solution

Kittaneh

Qurt

Malkieh³

et al. 2022

Pharmaceutics

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show abstract

“…Without plasticizers, they were found to be fragile. Then, to create films with good elasticity as reported in earlier experiments, dibutyl phthalate was added as a plasticizer to reduce the brittleness [24,36].…”

Section: Evaluation Of Filmsmentioning

confidence: 99%

Evaluating the Impact of Solid Microneedles on the Transdermal Drug Delivery System for Ɣ-Oryzanol

Kaur

Thakur

Goswami³

2022

Int J App Pharm

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Objective: This study's goals were to develop a minimally invasive array of biocompatible polymeric solid microneedles and formulate a transdermal patch of drug Ɣ-Oryzanol as per poke and patch technology. Methods: Scanning electron microscopy was used to analyse the morphology of the solid microneedle arrays, which were created using a stereolithography (SLA) printer with high-resolution capabilities (25 and 140 microns for the z and x axes, respectively). Transdermal Patches of Ɣ-Oryzanol were formulated and evaluated for various characterization parameters. Further, the produced microneedle-transdermal drug delivery system of Ɣ-Oryzanol was examined for microneedle insertion skin and permeation of the drug across the porcine skin. Results: Solid microneedle arrays were manufactured using biocompatible Class I Dental SG resin having dimensions of 600 µm height and 300 µm width with tip diameters of 30 µm and 1.85 mm interspacing (Distance from tip to tip) and they were strong enough to penetrate porcine skin to a depth of 381.356 µm crossing the stratum corneum layer without causing any structural changes. Transdermal patches containing Ɣ-Oryzanol were formulated using different ratios of HPMC: Eudragit E-100. Good, consistent, and transparent films were formulated when the thickness of the film ranges between 0.516±0.25-0.628±0.21 mm, average weights ranged from 168.23±2.61to171.22±1.25(10/cm2), folding endurance ranged in between 10 folds to 12 folds for all the formulations with tensile strength lie between the 0.365 kg/mm2 to 0.465 kg/mm2. All the formulations showed good drug content between 99.3±0.06%-90.4±1.64% with 100% flat surfaces. Moisture content was found in the range of 2.012±0.013 to 4.213±0.031. Drug permeation studies reveal that compound Ɣ-Oryzanol transdermal patches didn’t show significant permeation across porcine skin (4.802.25 g/cm2) without piercing with microneedles while after poking skin using microneedles (74.502.35 g/cm2) drug showed good penetration properties. It was found that the amount of drug delivered increased to 44.251.57 g/cm2 at 2 min, which was 14.502.35 g/cm2 at 1 min to 4 min 74.502.35 g/cm2. Conclusion: Successful preparation of the Microneedle-Transdermal drug delivery system of Ɣ-Oryzanol and their evaluation indicated that the quality and consistency of the formulated preparation were excellent. With advantages in terms of lowered dose frequency, better patient compliance, and bioavailability, this may find use in the therapeutic field.

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“…This meant sustained release time was longer than commercial patch. 48 Wang et al (2015), prepared and evaluated "Transdermal" patches using aceclofenac. Span-20 and limonene were used as penetration enhancers.…”

Section: Introductionmentioning

confidence: 99%

Recent advancements in transdermal patches

Sharma

Thakur

Kaur

et al. 2022

ijhs

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Transdermal route of drug administration is novel as well as reliable means of sustained drug delivery. With more and more research being carried out in this field and increasing interest of researchers in this form of drug delivery, number of transdermal devices reaching the marketplace are expected to increase sharply. The aim of this review is to present latest explorations carried out in recent years utilizing possible drug candidates. Also, new polymer candidates along with novel penetration enhancers have been presented. For the purpose of study, various databases viz. Sciencedirect, Web of Knowledge, Pubmed, Google Scholar, etc. have been explored. After going through all the research work done by researchers in recent past it is appropriate to state that transdermal route is no longer reliant on few polymers and penetration enhancers but studies have now provided lot many more options for transdermal device formulation as evident from the data compilations. It can be concluded that most of the researchers have been utilizing HPMC as the preferred film forming polymer but recently use of Eudragit grades also has gained interest amongst scientists.

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Formulation and evaluation of transdermal drug-delivery system of isosorbide dinitrate

Cited by 12 publications

References 17 publications

Preparation and Evaluation of Vitamin D3 Supplementation as Transdermal Film-Forming Solution

Preparation and Evaluation of Vitamin D3 Supplementation as Transdermal Film-Forming Solution

Evaluating the Impact of Solid Microneedles on the Transdermal Drug Delivery System for Ɣ-Oryzanol

Recent advancements in transdermal patches

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