A novel therapeutic design of microporous-structured biopolymer scaffolds for drug loading and delivery

Dorj, Biligzaya; Won, Jong‐Eun; Purevdorj, Odnoo; Patel, Kapil D.; Kim, Joong-Hyun; Lee, Eunjung; Kim, Hae‐Won

doi:10.1016/j.actbio.2013.11.002

Cited by 50 publications

(22 citation statements)

References 44 publications

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“…SAP microspheres were then sintered in a custom‐made copper mold to yield porous scaffolds. The chemical incorporation of SA into SAP backbone allows very high drug loading (up to 45%, determined by H 1 NMR) among bone regeneration scaffolds to date and displays sustained drug release (30–50 days) that is comparable to the duration of bone regeneration . In addition, the scaffolds have a modulus (10–30 MPa, determined by compression test) and porosity (∼60%, determined by micro‐computed tomography (micro‐CT)) within the suitable range for bone regeneration …”

Section: Introductionmentioning

confidence: 99%

Salicylic acid (SA)‐eluting bone regeneration scaffolds with interconnected porosity and local and sustained SA release

Bajorek

Jayade

et al. 2016

J Biomedical Materials Res

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In previous work, we observed that localized and sustained delivery of an anti-inflammatory drug, salicylic acid (SA), via a SA-based polymer (SAP) powder significantly enhanced diabetic bone regeneration through long-term mitigation of local inflammation. In this study, SAP was formulated into uniform microspheres and then sintered into a scaffold with an interconnected porous structure and modulus suitable for bone regeneration. The SAP scaffolds have ∼45% SA loading, which is the highest among drug-eluting bone regeneration scaffolds to-date. In addition, the scaffold provides localized, controlled and sustained SA release that has been proven to enhance diabetic bone regeneration. With the combination of physical (interconnected porosity) and chemical therapeutic features (high drug loading and sustained release), the novel SAP scaffolds offer unique therapeutic advantages and are promising diabetic bone regeneration candidates. © 2016 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 105A: 311-318, 2017.

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Section: Introductionmentioning

confidence: 99%

Salicylic acid (SA)‐eluting bone regeneration scaffolds with interconnected porosity and local and sustained SA release

Bajorek

Jayade

et al. 2016

J Biomedical Materials Res

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“…It can be suggested that the macroporosity of the scaffolds Biodegradable scaffolds can provide the initial structure for inducing new bone tissue formation, degrading into new bone tissue forms, providing room for matrix deposition and new bone tissue ingrowth. 22,23 In this study, it was found that the weight loss of the scaffolds in PBS solution gradually increased with the increase in soaking time, indicating that the scaffolds could be degradable. Moreover, the degradability of the scaffolds increased with the nDPB content (30nDGC.15nDGC.GL), indicating that the incorporation of nDPB into GL matrix obviously improved the degradability of the scaffolds.…”

Section: Discussionmentioning

confidence: 70%

Nanoporous diopside modulates biocompatibility, degradability and osteogenesis of bioactive scaffolds of gliadin-based composites for new bone formation

Chen

Huang

et al. 2018

IJN

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IntroductionIt is predicted that with increased life expectancy in the whole world, there will be a greater demand for synthetic biomedical materials to repair or regenerate lost, injured or diseased tissues. Natural polymers, as biomedical materials, have been widely applied in the field of regenerative medicine.Materials and methodsBy incorporation of nanoporous diopside bioglass (nDPB) into glia-din (GL) matrix, macro–nanoporous scaffolds of nDPB/GL composites (DGC) were fabricated by method of solution compressing and particles leaching.ResultsThe results revealed that the DGC scaffolds possessed well-interconnected macropores of 200–500 μm and nanopores of 4 nm, and the porosity and degradability of DGC scaffolds remarkably increased with the increase in nDPB content. In addition, in vitro cell experiments revealed that the adhesion and growth of MC3T3-E1 cells on DGC scaffolds were significantly promoted, which depended on nDPB content. Moreover, the results of histological evaluations confirmed that the osteogenic properties and degradability of DGC scaffolds in vivo significantly improved, which were nDPB content dependent. Furthermore, the results of immunohistochemical analysis demonstrated that, with the increase in nDPB content, the type I collagen expression in DGC scaffolds in vivo obviously enhanced, indicating excellent osteogenesis.Discussion and conclusionThe results demonstrated that the DGC scaffolds containing 30 wt% nDPB (30nDGC) exhibited good biocompatibility and new bone formation ability, which might have a great potential for applications in bone regeneration.

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“…It seeks to fabricate the living replacement parts of the body by using a combination of cells and biomaterials to form tissues and thus restore the physiological functions lost in the defect area. The scaffolds are the structures engineered to support the new tissue genesis and it provides a temporary substrate to which the transplanted cells can adhere, proliferate and maintain their differentiated function so that the developing tissue may grow in an organized way [3,4]. Growth factors function as a part of vast cellular communication network that influences critical functions such as migration of cells from one site to another, morphogenesis from one cell type to another, and mitogenesis or cellular proliferation [5,6].…”

Section: Introductionmentioning

confidence: 99%

Porous Chitosan Scaffolds: A Systematic Study for Choice of Crosslinker and Growth Factor Incorporation

Singh

Sirohi

Archana

et al. 2014

International Journal of Polymeric Materials and Polymeric Biom

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A systematic study was conducted to evaluate the crosslinker and method of incorporation for bovine serum albumin (BSA) into chitosan hybrid scaffolds (CH-ALG) for better cartilage tissue engineering applications. Formaldehyde and sodium tripolyphosphate were used crosslinkers for fabrication of CH-ALG scaffolds using BSA as growth factor by direct incorporation and microencapsulation methods. An in vitro release study of BSA with maximum release (80%) for scaffolds of formaldehyde crosslinked was found. The present findings show that the CH-ALG hybrid scaffolds have been potential use in biomedical applications.

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A novel therapeutic design of microporous-structured biopolymer scaffolds for drug loading and delivery

Cited by 50 publications

References 44 publications

Salicylic acid (SA)‐eluting bone regeneration scaffolds with interconnected porosity and local and sustained SA release

Salicylic acid (SA)‐eluting bone regeneration scaffolds with interconnected porosity and local and sustained SA release

Nanoporous diopside modulates biocompatibility, degradability and osteogenesis of bioactive scaffolds of gliadin-based composites for new bone formation

Porous Chitosan Scaffolds: A Systematic Study for Choice of Crosslinker and Growth Factor Incorporation

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