A Novel Spectrophotometric Method for Determination of Gabapentin in Pharmaceutical Formulations Using 2,5-Dihydroxybenzaldehyde

Saleh, Magda S.; Youssef, Adel F.; Hashem, Elham Y.; Abdel-Kader, Doaa A.

doi:10.4236/cc.2014.22004

Cited by 10 publications

(3 citation statements)

References 24 publications

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“…Numerous analytical techniques have been reported for determination of SSZ and its metabolites in different samples including high-performance liquid chromatography (HPLC), [6,7] liquid chromatography, [8] thin-layer chromatographydensitometry, [9] capillary electrophoresis-mass spectrometry, [10] solid phase extraction (SPE), [11] voltammetry, [3,12,13] spectrofluorimetry, [1,14] enzyme-linked immunosorbent assay, [4] spectrophotometry [15] and so on.…”

Section: Introductionmentioning

confidence: 99%

Molecularly Imprinted Sol‐Gel Sensing Film‐Based Optical Sensor for Determination of Sulfasalazine Antibiotic

et al. 2020

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In this study, a simplistic optical sensing approach for determination of sulfasalazine (SSZ) antibiotic has been developed by combining molecular imprinting and sol-gel techniques (MIP-SG). The sol-gel solution containing sulfasalazine (target molecule) was deposited as a thin film on the pretreated microscope glass slides to fabricate imprinted optical sensors. The binding properties of the sensor toward sulfasalazine were evaluated by UV-Vis spectroscopy method. The influence of some experimental parameters affecting on the manufacturing process as well as the response of MIP-SG sensing film were studied. Under optimal conditions, the UV-Vis signals of proposed sensor showed a linear relationship with the SSZ concentration in the range from 0.5 to 80.0 μg mL À 1 (R 2 = 0.994) and detection limit of 0.26 μg mL À 1 with benefits of good reproducibility (RSD = 4.12 %) and storage stability. This sensor was successfully used for determination of SSZ in well water, pharmaceutical formulation and human urine samples.

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Section: Introductionmentioning

confidence: 99%

Molecularly Imprinted Sol‐Gel Sensing Film‐Based Optical Sensor for Determination of Sulfasalazine Antibiotic

et al. 2020

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“…Several spectroscopic methods were developed for GBP analysis in pure form and in pharmaceutical formulations either with spectrophotometric or spectrofluorimetric determination. Due to the absence of strong absorbing chromophore in GBP, its direct spectrophotometric analysis is problematic and mostly depends on the derivatization with chemical reagents (Adegbolagun et al, 2018;Adegoke et al, 2018;Ambala and Patel, 2011;Fonseca et al, 2017;Gouda and Malah, 2013;Gujral et al, 2009;Saleh et al, 2014;Siddiqui et al, 2010). The official methods for the identification and quantitation analysis of GBP are prescribed in BP and USP (BP, 2015;USP 32, 2009).…”

Section: Introductionmentioning

confidence: 99%

Development and validation of spectrophotometric method for determination of gabapentin in bulk and pharmaceutical dosage forms based on Schiff base formation with salicylaldehyde

2019

J App Pharm Sci

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A sensitive, simple, and economic spectrophotometric method was developed and validated for the determination of gabapentin in pure form and pharmaceutical preparations. The method is based on Schiff base condensation reaction of the primary amino group of gabapentin with salicylaldehyde reagent in the presence of acetate solution at 45°C for 20 minutes. The obtained yellow-colored derivative in methanolic medium showed absorption maxima at 403 nm. Under the optimum conditions, Beer's law was obeyed in the concentration range of 6 to 100 μg/ml with correlation coefficient value of 0.9961. Limit of detection and limit of quantification were found to be 1.16 and 3.48 μg/ml, respectively. The validity of the described method was assessed according to the International Conference on Harmonization guidelines. The mean percentage recoveries ± SD were 100.57 ± 1.5 by applying the standard addition technique. The method was repeatable and precise (RSD ≤ 0.61% and ≤ 1.34%, respectively) and was successfully applied for the determination of the investigated drug in its pharmaceutical dosage form without detectable interference from the additives, hence, can be suggested for routine analysis of the gabapentin.

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“…A glance over the literature revealed few reports regarding charge transfer complexes for PG and TXA. A structural analogous of PG and TXA gabapentin has been determined by colorimetry-visible spectrophotometry by reacting with iodine, chloranil, chloranilic acid, 2,3-dichloro-5,6-dicyano-1,4-benzoquinone, tetracyanoethylene, methyl orange, hydroxy benzaldehyde, picric acid and with ninhydrin [ 28 – 30 ]. Colorimetric spectrophotometric methods for PG include reaction with 1,2-naphthoquinone-4-sulphonate sodium and 2,4-dinitrofluorobenzene [ 5 ], ascorbic acid and salicylaldehyde [ 6 ], 7,7,8,8-tetracyanoquinodimethane, 2,3-dichloro-5,6-dicyano-1,4-benzoquinone, 2,5-dichloro-3,6-dihydroxy-1,4-benzoquinone, tetracyanoethylene and 2,3,5,6-tetrachloro-1,4-benzoquinone [ 7 ], quinalizarin and alizarin [ 8 ], and vanillin, acetyl acetone, and formaldehyde [ 9 ].…”

Section: Introductionmentioning

confidence: 99%

Pregabalin and Tranexamic Acid Evaluation by Two Simple and Sensitive Spectrophotometric Methods

Sher

Fatima

Perveen

et al. 2015

International Journal of Analytical Chemistry

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This paper demonstrates colorimetric visible spectrophotometric quantification methods for amino acid, namely, tranexamic acid and pregabalin. Both drugs contain the amino group, and when they are reacted with 2,4-dinitrophenol and 2,4,6-trinitrophenol, they give rise to yellow colored complexes showing absorption maximum at 418 nm and 425 nm, respectively, based on the Lewis acid base reaction. Detailed optimization process and stoichiometric studies were conducted along with investigation of thermodynamic features, that is, association constant and standard free energy changes. The method was linear over the concentration range of 0.02–200 µgmL−1 with correlation coefficient of more than 0.9990 in all of the cases. Limit of detection was in range from 0.0041 to 0.0094 µgmL−1 and limit of quantification was in the range from 0.0137 to 0.0302 µgmL−1. Excellent recovery in Placebo spiked samples indicated that there is no interference from common excipients. The analytical methods under proposal were successfully applied to determine tranexamic acid and pregabalin in commercial products. t-test and F ratio were evaluated without noticeable difference between the proposed and reference methods.

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A Novel Spectrophotometric Method for Determination of Gabapentin in Pharmaceutical Formulations Using 2,5-Dihydroxybenzaldehyde

Cited by 10 publications

References 24 publications

Molecularly Imprinted Sol‐Gel Sensing Film‐Based Optical Sensor for Determination of Sulfasalazine Antibiotic

Molecularly Imprinted Sol‐Gel Sensing Film‐Based Optical Sensor for Determination of Sulfasalazine Antibiotic

Development and validation of spectrophotometric method for determination of gabapentin in bulk and pharmaceutical dosage forms based on Schiff base formation with salicylaldehyde

Pregabalin and Tranexamic Acid Evaluation by Two Simple and Sensitive Spectrophotometric Methods

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