Development and validation of spectrophotometric method for determination of gabapentin in bulk and pharmaceutical dosage forms based on Schiff base formation with salicylaldehyde
Abstract:A sensitive, simple, and economic spectrophotometric method was developed and validated for the determination of gabapentin in pure form and pharmaceutical preparations. The method is based on Schiff base condensation reaction of the primary amino group of gabapentin with salicylaldehyde reagent in the presence of acetate solution at 45°C for 20 minutes. The obtained yellow-colored derivative in methanolic medium showed absorption maxima at 403 nm. Under the optimum conditions, Beer's law was obeyed in the con… Show more
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