Molecularly Imprinted Sol‐Gel Sensing Film‐Based Optical Sensor for Determination of Sulfasalazine Antibiotic

Abstract

In this study, a simplistic optical sensing approach for determination of sulfasalazine (SSZ) antibiotic has been developed by combining molecular imprinting and sol-gel techniques (MIP-SG). The sol-gel solution containing sulfasalazine (target molecule) was deposited as a thin film on the pretreated microscope glass slides to fabricate imprinted optical sensors. The binding properties of the sensor toward sulfasalazine were evaluated by UV-Vis spectroscopy method. The influence of some experimental parameters affecting on the manufacturing process as well as the response of MIP-SG sensing film were studied. Under optimal conditions, the UV-Vis signals of proposed sensor showed a linear relationship with the SSZ concentration in the range from 0.5 to 80.0 μg mL À 1 (R 2 = 0.994) and detection limit of 0.26 μg mL À 1 with benefits of good reproducibility (RSD = 4.12 %) and storage stability. This sensor was successfully used for determination of SSZ in well water, pharmaceutical formulation and human urine samples.

A 3,8-connected Cd(ii)-based metal–organic framework as an appropriate luminescent sensor for the antibiotic sulfasalazine

“…However, on introducing SLA to the mixture of 1 and other antibiotics, the emission intensity of 1 was significantly quenched, which is indicative of its high selectivity toward SLA. To the best of our knowledge, only seven complex-derived probes for SLA have been reported to date (Table 2), [37][38][39][40][41][42] which suggests that the sensing properties of 1 presented in this work are comparable to most of the reported fluorescent probes. 43,44 Further, the recyclability of 1 as a sensor for SLA was examined and the outcomes of the recycling experiments are shown in Fig.…”

The Role of Molecularly Imprinted Polymers In Sensor Technology: Electrochemical, Optical and Piezoelectric Sensor Applications

“…The UV-Vis spectroscopy technique was used to determine the binding characteristics of the sulfasalazine sensor. The 0.26 g/mL detection limit was chosen because of its high reproducibility (RSD = 4.1%) (80). An optical sensor device based on fluorescence was created by Chen et al to measure anthracene.…”