A novel SNP of the GHRL gene in goat and its association with growth traits

Jin, Qijiang; Fang, Xinggen; Zhang, C.L.; Yang, Liu; Sun, Jian; Chen, D.X.; Shi, Xinying; Du, Yong‐Zhong; Lan, Xianyong; Chen, H.

doi:10.1016/j.smallrumres.2010.01.001

Cited by 10 publications

(8 citation statements)

References 11 publications

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“…Kim et al (2004) found single polymorphism in the third exon of porcine GHRL gene, which was correlated with a several porcine traits, such as marbling, backfat thickness and weights of loin and ham. Jin et al (2010) investigated several polymorphisms in caprine ghrelin gene and they confirmed association between mutation in second intron (G147A) and growth traits such as: circumference of chest and cannon, and also trunk index (P<0.05 and P<0.01). The authors observed tendency that genotype AG had better performance in body height and body length than genotype GG, although no significant differences were observed.…”

Section: Discussionmentioning

confidence: 79%

New polymorphisms and expression of the porcine ghrelin (<i>GHRL</i>) gene in different pig breeds

Ropka‐Molik¹,

Oczkowicz²,

Piórkowska³

et al. 2011

J. Anim. Feed Sci.

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Growth and development traits are economically important in animal production, especially in pig breeding. Therefore, the porcine GHRL gene is considered as a candidate gene responsible for growth rate and body weight. The aim of our study was to identify new polymorphisms in the GHRL gene in pig. Ten novel single nucleotide polymorphisms (SNP's) were detected: four substitutions in exons, four in introns and two mutations in promoter region. We evaluated the GHRL mRNA abundance in porcine stomachs (fundus ventriculis) and ghrelin protein concentration in plasma in three breeds: Polish Landrace, Polish Large White and Pietrain. The results showed that transcript abundance of GHRL gene was significantly higher in Polish Landrace than in other two breeds (P<0.05). The mutation c.-93A>G located in the promoter region affected expression of the GHRL gene. The AA genotype animals showed a significantly (P<0.05) higher expression level when compared to AG genotype animals.

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Section: Discussionmentioning

confidence: 79%

New polymorphisms and expression of the porcine ghrelin (<i>GHRL</i>) gene in different pig breeds

Ropka‐Molik¹,

Oczkowicz²,

Piórkowska³

et al. 2011

J. Anim. Feed Sci.

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“…All of them are located in the non-coding parts of the gene [4]. Also in goats, SNP in the GHRL gene was found and it is also located in the non-coding sequence [7].…”

Section: Discussionmentioning

confidence: 99%

“…Polymorphism in the gene coding for ghrelin with regard to various traits of an organism has only been analyzed in cattle [11] and goats [7] so far. In the case of both studied species, an association between the analyzed SNPs and traits such as feed conversion index or growth rate was found.…”

Section: Discussionmentioning

confidence: 99%

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Ghrelin gene polymorphism in dairy cattle

Kowalewska-Łuczak¹,

Szembek²,

Kulig³

2011

JCEA

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The aim of this experiment was to estimate possible associations between GHRL G375A genotypes and some milk performance traits (yields of milk, protein and fat, and protein and fat content). The study included Polish Holstein-Friesian strain Red-and-White cows. The ACRS and PCR-RFLP method was used to identification genotypes. GHRL G375A frequencies were as follow: AA-0.86, AG-0.14, and GG-was not found, while allele frequencies were: A-0.93 and G-0.07. In this study, no statistically significant correlation between GHRL genotypes and analyzed traits was found, however, a tendency to maintain a relationship of genotypes with milk production traits is shown.

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“…to evaluate the meat production related performance traits, the phenotypic traits of the goats, body length, chest circumference, body height, trunk circumference and cannon circumference were measured directly. Body length index, chest circumference index, cannon circumference index and trunk index were estimated as described in a previous association study (JIN et al, 2010). PCR-SSCP and SNP identification.…”

Section: Methodsmentioning

confidence: 99%

Association of a novel single nucleotide polymorphism at the exon‑2 of Insulin-Like Growth Factor 1 (IGF1) gene with phenotypic variants in goats

Thomas¹,

Venkatachalapathy²,

Aravindakshan³

et al. 2017

Vet. arhiv

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ABSTRACTthe Insulin-Like Growth Factor 1 plays a key role in foetal development and post natal growth. the objectives of this study were to characterise the complete coding sequence of caprine IGF1 gene in two indigenous goat breeds of India: Malabari and attappady Black, to detect polymorphisms of IGF1 gene, to investigate their effects on body size traits and to ascertain the relative expression of IGF1 mrNa in muscle tissues of goats belonging to low and high body weight groups. All the four exons of caprine IGF1 gene were amplified and characterized by PCr-SSCP in 298 goats, revealing two genotypes (CC and Ct) at exon 2. Sequencing of the PCr products from each genotype revealed a novel SNP, g.80C>t (GenBank accession No. kM974180), which caused a non-synonymous mutation (thr48Met),causing differences in IGF1 protein structure. association analysis of the loci indicated Ct genotypes have higher body length (P<0.01), chest circumference (P<0.01) and body length index (P<0.05) than CC genotypes. two novel PCr-rFLPs were designed for the rapid detection of the genotypes. the quantitative real time PCr demonstrated a difference in the expression of IGF1 mrNa in muscle tissues of the low and high body weight groups, but it was not significant (P>0.05). The results of the *Corresponding author: Dr. Naicy thomas, M.V.Sc., PhD, assis. Prof., Department of animal Breeding, Genetics and Biostatistics, College of Veterinary and animal Sciences, Mannuthy, thrissur-680651, kerala, India, Phone: +91 94 4611 9307; e-mail: naicy@kvasu.ac.in 458Vet. arhiv 87 (4), [457][458][459][460][461][462][463][464][465][466][467][468][469][470][471][472] 2017 t. Naicy et al.: association of IGF1 gene polymorphism with phenotypic variants in goats present study suggest that the alleles of the IGF1 gene could be considered as strong targets for improvement of growth traits in goats.

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A novel SNP of the GHRL gene in goat and its association with growth traits

Cited by 10 publications

References 11 publications

New polymorphisms and expression of the porcine ghrelin (<i>GHRL</i>) gene in different pig breeds

New polymorphisms and expression of the porcine ghrelin (<i>GHRL</i>) gene in different pig breeds

Ghrelin gene polymorphism in dairy cattle

Association of a novel single nucleotide polymorphism at the exon‑2 of Insulin-Like Growth Factor 1 (IGF1) gene with phenotypic variants in goats

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