Ghrelin gene polymorphism in dairy cattle

Kowalewska-Łuczak, Inga; Szembek, Maria; Kulig, H.

doi:10.5513/jcea01/12.4.984

Cited by 4 publications

(3 citation statements)

References 10 publications

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“…[4] and [5] reported that the GHLR gene expression effected significantly on milk production through the main effect on the intravenous glucose following in dairy cattle and the direct effects of ghrilin-obestatin on somatotropic axes. Other studies presented that the GHRL is the strongest stimulator of food intake in all mammalian species and the gene polymorphism in many sites is correlated strongly with variant of milk production [11,12]. The results are similar with the results of [13] who reported that the GHRL gene is considered as the main key to regulate metabolism and the functions of cardiovascular in mammals which is reflex on milk production.…”

Section: Resultssupporting

confidence: 83%

Relationship of GHRL Gene Polymorphism with Milk Production and Components in Holstein Cows

Shnawa,

Al- Khuzai,

Al-Yaseri

2023

IOP Conf. Ser.: Earth Environ. Sci.

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The current study was conducted in private station located in the middle of Iraq by using 100 samples of blood to determine the effect of GHRL gene polymorphism on milk traits in Holstein cows. Results showed two alleles with co-dominance and three genotypes was detected in the site -97, the allele frequency was 0.72 and 0.28 for G and A allele respectively. Results showed a significant effect of SNP on lactation period length (P<0.01). The cows with mutant genotype (AA) were the longest lactation period (241 day) while the cows with wild genotype were the shortest lactation period. Total milk yield affected significantly (P<0.01) by allele type, the highest quantity of milk yield was in cows with mutant genotype namely, 3366.77 Kg. High significant differences in daily milk yield were reported in cows according the alleles type, AA cows genotypes achieved 13.97 Kg /day compared with the cows with GG genotype which achieved 8.82 kg/day. Milk components such as lactose and protein were affected significantly (P<0.01) by GHRL gene SNP, the highest rate of lactose and protein were noticed in cows with wild genotype namely, 5.45 and 3.60% respectively. Milk fat differed significantly (P<0.05) in cows depending on its genotype, the highest rate was recorded in cows with wild genotype (GG) namely 3.90%.

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Section: Resultssupporting

confidence: 83%

Relationship of GHRL Gene Polymorphism with Milk Production and Components in Holstein Cows

Shnawa,

Al- Khuzai,

Al-Yaseri

2023

IOP Conf. Ser.: Earth Environ. Sci.

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“…The authors reported that in the ghrelin gene, no significant associations were revealed between any variant sites and BW, ADG, body sizes for different growth periods (6, 12, 18, and 24 mo old), or milk yield at 305 d, milk protein rate, and milk fat percentage. Kowalewska-Łuczak et al (2011) analyzed the ghrelin gene in 169 Holstein-Friesian cows and found a G/A polymorphism on intron 3 of the gene. The authors analyzed the association of this polymor-phism with milk-production traits, but no significant differences between the genotypes were described.…”

Section: Introductionmentioning

confidence: 99%

Polymorphisms in the ghrelin gene and their associations with milk yield and quality in water buffaloes

Gil

Camargo

Souza

et al. 2013

Journal of Dairy Science

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Ghrelin is a gastrointestinal hormone that acts in releasing growth hormone and influences the body general metabolism. It has been proposed as a candidate gene for traits such as growth, carcass quality, and milk production of livestock because it influences feed intake. In this context, the aim of this study was to verify the existence of polymorphisms in the ghrelin gene and their associations with milk, fat and protein yield, and percentage in water buffaloes (Bubalus bubalis). A group of 240 animals was studied. Five primer pairs were used and 11 single nucleotide polymorphisms (SNP) were found in the ghrelin gene by sequencing. The animals were genotyped for 8 SNP by PCR-RFLP. The SNP g.960G>A and g.778C>T were associated with fat yield and the SNP g.905T>C was associated with fat yield and percentage and protein percentage. These SNP are located in intronic regions of DNA and may be in noncoding RNA sites or affect transcriptional efciency. The ghrelin gene in buffaloes influences milk fat and protein synthesis. The polymorphisms observed can be used as molecular markers to assist selection.

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“…Researchers have detected polymorphisms in ghrelin genes which are associated with carcass and meat quality traits in pigs [12,30], growth and feeding traits in chickens [20], growth traits in goats [31], birth weight and body length in cattle [16], and milk fat and protein synthesis in water buffaloes (Bubalus bubalis) [32]. On the other hand, some of the research results have not shown any association with phenotypes, e.g., studies on humans [33], pigs [23], cattle [34], and sheep [35]. In this study, the genotype frequency of three polymorphisms were identified: one in the promoter region (c.-93A>G) and two in the 3’UTR sequence (g.4428T>C and g.4486C>T).…”

Section: Resultsmentioning

confidence: 99%

Association of Ghrelin Gene Polymorphisms with Fattening Traits and Feed Intake in Pig: A Preliminary Study

Tyra

Ropka‐Molik

Piórkowska

et al. 2019

Animals

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Numerous studies have been conducted to explain the biological functions and mechanism of ghrelin (GHRL) action in animals. However, the exact role of ghrelin in the regulation of growth and development in pigs is still unclear. The ghrelin gene is considered to be a good candidate marker for the identification of economically important traits in pig production such as feed intake, growth or carcass quality. The objectives of the present study were to investigate the regulatory regions and coding sequence of the porcine GHRL gene and determine the effect of polymorphisms at the ghrelin gene locus on selected fattening traits. Data were obtained from 346 gilts (pure breeds: Landrace, 188; Duroc, 74; Pietrain, 84). The PCR-RFLP (Polymerase Chain Reaction-Restriction Fragment Length Polymorphism) method was used to detect polymorphisms within GHRL. Three polymorphisms were found, one in the promoter region (c.-93A>G) and two in the 3’UTR sequence (g.4428T>C; g.4486C>T). A significant (p ≤ 0.01) additive effect on daily gain (negative) and age at slaughter (positive) was obtained at the locus c.-93A>G. However, the most promising mutation was at the locus g.4486C > T, which is associated with total feed intake. Overall, the described GHRL polymorphisms may be useful as molecular markers in pig selection but future studies are required.

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Ghrelin gene polymorphism in dairy cattle

Cited by 4 publications

References 10 publications

Relationship of GHRL Gene Polymorphism with Milk Production and Components in Holstein Cows

Relationship of GHRL Gene Polymorphism with Milk Production and Components in Holstein Cows

Polymorphisms in the ghrelin gene and their associations with milk yield and quality in water buffaloes

Association of Ghrelin Gene Polymorphisms with Fattening Traits and Feed Intake in Pig: A Preliminary Study

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