A novel sensitive cell-based Love Wave biosensor for marine toxin detection

Zhang, Xi; Fang, Jian; Zou, Ling; Zou, Yingchang; Lang, Lang; Gao, Fan; Hu, Ning; Wang, Ping

doi:10.1016/j.bios.2015.07.062

Cited by 43 publications

(22 citation statements)

References 33 publications

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“…To date, most of studies used Love mode acoustic wave sensors as immunosensors , which has limitations of complicated regents preparation and the detection of single agent only compared with cell‐based sensors. There are very few publications on Love mode SAW sensors for cytotoxicity sensing . The performance of Love mode SAW sensors for cytotoxicity sensing is not clear and needs to be synthetically studied.…”

Section: Introductionmentioning

confidence: 99%

Love mode surface acoustic wave and impedance sensors for water toxicity sensing

Furniss

Qin

et al. 2017

Env Prog and Sustain Energy

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Clean water supply systems and infrastructure require periodic testing of water samples to maintain water quality. To enable this, toxicity tests need to be rapid, accurate, portable, and low cost to provide affordable water security especially in developing countries. Qualitative and quantitative measurement of contaminants in water is classically done by standard analytic chemical methods, which are timeconsuming, labor-intensive, expensive, and cannot be performed easily outside the laboratory. An alternative to these methods is cell-based sensors, which can detect the presence of a wide range of toxicants by monitoring the cell states. Although electric cell-substrate impedance sensing (ECIS) has been demonstrated to be an effective method for water toxicity sensing, the use of ECIS only is not sensitive enough to detect many toxicants at low concentrations. Merging a sensor platform with multiparametric measurement capabilities could increase the security of detection. Love mode surface acoustic wave (SAW) device is considered as one of the powerful candidates for cell-based toxicity biosensors. In this study, a hybrid Love mode SAW/ECIS sensor was developed. Theoretical analysis and experiments were performed to demonstrate the capability of two sensing techniques (i.e., SAW and ECIS) for toxicity sensing.

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Section: Introductionmentioning

confidence: 99%

Love mode surface acoustic wave and impedance sensors for water toxicity sensing

Furniss

Qin

et al. 2017

Env Prog and Sustain Energy

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“…1 SAW based sensors and microfluidics have recently been intensively 3 reported for a variety of applications in biological, chemical, and medical engineering. [2][3][4][5] So far, Rayleigh SAWs are the most commonly used wave mode in SAW based microfluidics, which are composed of longitudinal and vertically polarized displacement components, thus they are strongly coupled into the liquid media located on their propagation paths. Therefore, they have been extensively applied to generate microfluidic functions, including mixing, pumping, ejection, nebulization and jetting.…”

mentioning

confidence: 99%

Vertical jetting induced by shear horizontal leaky surface acoustic wave on 36° Y-X LiTaO3

Quan

Luo

et al. 2017

Applied Physics Letters

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Shear horizontal surface acoustic waves (SH-SAWs) have been regarded as good candidates for liquid sensing applications but are inefficient in fluid manipulation due to a minimal fluid coupling between the fluid and acoustic waves. However, in this letter, a vertical jetting function was realized using the SH-SAW generated from a 36° Y-X LiTaO3 SAW device. The jetting of the droplet induced by the SH-SAWs was observed nearly along the vertical direction, and the aspect ratio of the liquid beam is proportional to the applied power before breaking up, which is dramatically different from those generated from the conventional Rayleigh SAWs. By conducting theoretical simulation and experimental investigation on the SH-SAWs systematically, we concluded that the wave/energy pressure dissipated into the sessile droplets causes this vertical ejection on the device surface.

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“…BLI is an emerging sensor platform with great potential. 56 It can monitor the surface property of the sensor, when the immobilized ligand is combined with the target molecule by biolayer interferometry technology in real time. 57 At this stage, there have been reports of the BLI sensors used on small molecule detection.…”

Section: Bli Aptasensor For Dtx-1 Detectionmentioning

confidence: 99%

Selection and application of aptamers with high-affinity and high-specificity against dinophysistoxin-1

Zhou

et al. 2020

RSC Adv.

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A novel sensitive cell-based Love Wave biosensor for marine toxin detection

Cited by 43 publications

References 33 publications

Love mode surface acoustic wave and impedance sensors for water toxicity sensing

Love mode surface acoustic wave and impedance sensors for water toxicity sensing

Vertical jetting induced by shear horizontal leaky surface acoustic wave on 36° Y-X LiTaO3

Selection and application of aptamers with high-affinity and high-specificity against dinophysistoxin-1

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