A novel polyurethane modified with biomacromolecules for small-diameter vascular graft applications

Asadpour, Shiva; Yeganeh, Hamid; Ai, Jafar; Ghanbari, Hossein

doi:10.1007/s10853-018-2321-5

Cited by 39 publications

(26 citation statements)

References 35 publications

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“…Synthetic vascular grafts based on various polymers, such as polyethylene terephthalate (PET, Dacron®) and expanded polytetrafluoroethylene (ePTFE, Gore‐Tex®), are suitable alternatives widely used to treat large‐diameter blood vessel diseases (inner diameter > 6 mm) . However, their high thrombogenicity and poor elastic properties limit their further application in microvascular surgeries . Small‐diameter vascular grafts based on PET and ePTFE tend to induce a series of complications, such as thrombosis and intimal hyperplasia, because of hemodynamic differences between large and small blood vessels .…”

Section: Introductionmentioning

confidence: 99%

“…[4][5][6][7][8] However, their high thrombogenicity and poor elastic properties limit their further application in microvascular surgeries. [9][10][11][12][13] Small-diameter vascular grafts based on PET and ePTFE tend to induce a series of complications, such as thrombosis and intimal hyperplasia, because of hemodynamic differences between large and small blood vessels. 14 One of the effective approaches to prevent thrombosis and maintain a high patency is to quickly regenerate an endothelium on the inner surface of the vascular prosthesis in vivo in a manner similar to that of native blood vessels.…”

Section: Introductionmentioning

confidence: 99%

“…Numerous strategies have been developed to improve cells adhesion and proliferation performance, resulting in endothelialization in vitro and in vivo. 12,[14][15][16][17][18][19][20][21][22][23][24][25][26] Shin 27 et al enhanced the endothelialization of poly(L-lactide-co-ε-caprolactone) vascular grafts through polydopamine coating and the immobilization of vascular endothelial growth factors. Inseong 28 et al utilized PDA as an adaptor to graft heparin onto polyurethane substrates, leading to the enhancement of blood compatibility.…”

Section: Introductionmentioning

confidence: 99%

“…Numerous strategies have been developed to improve cells adhesion and proliferation performance, resulting in endothelialization in vitro and in vivo . Shin et al enhanced the endothelialization of poly( l ‐lactide‐ co ‐ε‐caprolactone) vascular grafts through polydopamine coating and the immobilization of vascular endothelial growth factors.…”

Section: Introductionmentioning

confidence: 99%

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Surface modification of polyvinyl alcohol (PVA)/polyacrylamide (PAAm) hydrogels with polydopamine and REDV for improved applicability

Xing

et al. 2019

J Biomed Mater Res

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Developing a small‐diameter vascular graft with a satisfactory performance in terms of mechanical and biological properties remains a challenging issue because of comprehensive requirements from clinical applications. Polyvinyl alcohol (PVA)/polyacrylamide (PAAm) hydrogels exhibit many desirable characteristics for small‐diameter vascular grafts because of their tunable mechanical properties, especially high compliance. However, poor cells adhesion hinders their application for endothelialization in situ. Therefore, in the present work, polydopamine (PDA) and tetrapeptide Arg‐Glu‐Asp‐Val (REDV) were used to functionalize the hydrogels surface and improve cells adhesion. A series of characterizations were systematically conducted to examine the applicability of coated hydrogels to small‐diameter vascular grafts. Results showed that bare and coated hydrogels have appropriate structural stability, and no significant differences in tensile properties could be found after being coated with PDA or PDA‐REDV. The hydrophilicity of the hydrogels decreased with the coatings of PDA and especially PDA‐REDV to improve protein adsorption, porcine iliac artery endothelial cells (PIECs) adhesion, viability, proliferation, and spreading on the hydrogels. Lower hemolysis percentages and higher blood clotting index values were attained for the hydrogels, suggesting their satisfactory hemocompatibility. Overall, the present work provided insights into the development of a novel hydrogel‐based small‐diameter vascular graft. © 2019 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater 108B:117–127, 2020.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Surface modification of polyvinyl alcohol (PVA)/polyacrylamide (PAAm) hydrogels with polydopamine and REDV for improved applicability

Xing

et al. 2019

J Biomed Mater Res

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“…It has a wide range of physicochemical, mechanical, and thermal properties (Guan, Fujimoto, Sacks, & Wagner, ; Kucinska‐Lipka, Gubanska, Janik, & Sienkiewicz, ). To increase cytocompatibility and hemocompatibility, we have previously developed of the surface modified PU nanofibers with VEGF and heparin (Davoudi et al, ), PU/silica composites (Rashti et al, ), POMS/PU nanocomposites (Yahyaei, Mohseni, & Ghanbari, ), and the new polyurethane modified with biomacromolecules (Asadpour, Yeganeh, Ai, & Ghanbari, ), ferulic acid (Asadpour et al, ) and PCL (Asadpour et al, ) for cardiovascular applications.…”

Section: Introductionmentioning

confidence: 99%

Development of electrically conductive hybrid nanofibers based on CNT‐polyurethane nanocomposite for cardiac tissue engineering

Shokraei

Asadpour

Shokraei

et al. 2019

Microscopy Res & Technique

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Conductive nanofibers have been considered as one of the most interesting and promising candidate scaffolds for cardiac patch applications with capability to improve cell–cell communication. Here, we successfully fabricated electroconductive nanofibrous patches by simultaneous electrospray of multiwalled carbon nanotubes (MWCNTs) on polyurethane nanofibers. A series of CNT/PU nanocomposites with different weight ratios (2:10, 3:10, and 6:10wt%) were obtained. Scanning electron microscopy, conductivity analysis, water contact angle measurements, and tensile tests were used to characterize the scaffolds. FESEM showed that CNTs were adhered on PU nanofibers and created an interconnected web‐like structures. The SEM images also revealed that the diameters of nanofibers were decreased by increasing CNTs. The electrical conductivity, tensile strength, Young's modulus, and hydrophilicity of CNT/PU nanocomposites also enhanced after adding CNTs. The scaffolds revealed suitable cytocompatibility for H9c2 cells and human umbilical vein endothelial cells (HUVECs). This study indicated that simultaneous electrospinning and electrospray can be used to fabricate conductive CNT/PUnanofibers, resulting in better cytocompatibility and improved interactions between the scaffold and cardiomyoblasts.

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Controlling Cell Behavior through the Design of Biomaterial Surfaces: A Focus on Surface Modification Techniques

Amani

Arzaghi

Bayandori

et al. 2019

Adv Materials Inter

305

200

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Surface interaction at the biomaterial–cell interface is essential for a variety of cellular functions, such as adhesion, proliferation, and differentiation. Nevertheless, changes in the biointerface enable to trigger specific cell signaling and result in different cellular responses. In order to manufacture biomaterials with higher functionality, biomaterials containing immobilized bioactive ligands have been widely introduced and employed for tissue engineering and regenerative medicine applications. Moreover, a number of physical and chemical strategies have been used to improve the functionality of biomaterials and specifically at the material interface. Here, the interactions between materials and cells at the interface levels are described. Then, the importance of surface properties in cell function is discussed and recent methods for surface modifications are systematically highlighted. Additionally, the impact of bulk material properties on the cellular responses is briefly reviewed.

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A novel polyurethane modified with biomacromolecules for small-diameter vascular graft applications

Cited by 39 publications

References 35 publications

Surface modification of polyvinyl alcohol (PVA)/polyacrylamide (PAAm) hydrogels with polydopamine and REDV for improved applicability

Surface modification of polyvinyl alcohol (PVA)/polyacrylamide (PAAm) hydrogels with polydopamine and REDV for improved applicability

Development of electrically conductive hybrid nanofibers based on CNT‐polyurethane nanocomposite for cardiac tissue engineering

Controlling Cell Behavior through the Design of Biomaterial Surfaces: A Focus on Surface Modification Techniques

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