A Novel Point of Care Diagnostic Device: Impedimetric Detection of a Biomarker in Whole Blood

McMurray, A.A.; Ali, Zulfiqur; Kyselovik, J.; Mills, Christopher A.; Jaffrezic‐Renault, Nicole; Sántha, H.; Strohhöfer, C.

doi:10.1109/iembs.2007.4352236

Cited by 5 publications

(5 citation statements)

References 34 publications

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“…188 McMurray et al developed an impedance biosensor based on functionalized nanoelectrodes for the detection of D-dimer protein (for diagnosis of presence of blood clot) in whole blood. 189 Surface plasmon resonance (SPR) is another technique that could use a microcell-based approach to detect analytes in undiluted biological samples. 190 For example, Liu et al developed a smartphone attachment (Figure 2F) to perform surface plasmon resonance (SPR) measurements inside a capillary and monitored specifically the binding of antibodies to a functionalized sensing element.…”

Section: Microcell-based Sensing For Ehealthmentioning

confidence: 99%

“…Nidzworski et al proposed an impedance-based method to detect anti-M1 antibodies (biomarker of influenza virus) in throat saliva or nasal samples by using functionalized boron-doped diamond electrodes . McMurray et al developed an impedance biosensor based on functionalized nanoelectrodes for the detection of D-dimer protein (for diagnosis of presence of blood clot) in whole blood . Surface plasmon resonance (SPR) is another technique that could use a microcell-based approach to detect analytes in undiluted biological samples .…”

Section: Microcell-based Sensing For Ehealth Applicationsmentioning

confidence: 99%

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From Point-of-Care Testing to eHealth Diagnostic Devices (eDiagnostics)

2018

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Point-of-care devices were originally designed to allow medical testing at or near the point of care by health-care professionals. Some point-of-care devices allow medical self-testing at home but cannot fully cover the growing diagnostic needs of eHealth systems that are under development in many countries. A number of easy-to-use, network-connected diagnostic devices for self-testing are needed to allow remote monitoring of patients’ health. This Outlook highlights the essential characteristics of diagnostic devices for eHealth settings and indicates point-of-care technologies that may lead to the development of new devices. It also describes the most representative examples of simple-to-use, point-of-care devices that have been used for analysis of untreated biological samples.

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Section: Microcell-based Sensing For Ehealthmentioning

confidence: 99%

Section: Microcell-based Sensing For Ehealth Applicationsmentioning

confidence: 99%

From Point-of-Care Testing to eHealth Diagnostic Devices (eDiagnostics)

2018

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“…A high specificity immunoassay-based diagnostics device combining impedimetric analysis nanoelectrodes and microfluidics has been developed to measure the whole blood concentration of D-dimer, a recognized biomarker of increased blood clotting activity in deep vein thrombosis (DVT) [51]. This device could improve the accuracy and reliability of early assessment of patients with risk of DVT.…”

Section: Nanotechnology For Ex Vivo Biomarkers Harvesting and Detectionmentioning

confidence: 99%

Emerging applications of nanomedicine for the diagnosis and treatment of cardiovascular diseases

Godin

Sakamoto

Serda

et al. 2010

Trends in Pharmacological Sciences

212

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Nanomedicine is an emerging field of medicine which utilizes nanotechnology concepts for advanced therapy and diagnostics. This convergent discipline, which merges research areas such as chemistry, biology, physics, mathematics and engineering thus bridging the gap between molecular and cellular interactions, has a potential to revolutionize current medical practice. This review presents recent developments in nanomedicine research, which are poised to have an important impact on cardiovascular disease and treatment by improving therapy and diagnosis of such cardiovascular disorders as atherosclerosis, restenosis and myocardial infarction. Specifically, we discuss the use of nanoparticles for molecular imaging and advanced therapeutics, specially designed drug eluting stents and in vivo/ex vivo early detection techniques.

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“…Passive capillary flow input of patient whole blood, or filtered blood/serum, makes such devices simpler to use, and easier and cheaper to manufacture than other micropumped systems. Another group in UK [ 150 ] also proposed a point-of-care diagnostic device for a more reliable and earlier assessment of deep vein thrombosis and related blood clotting conditions. The device measures whole blood concentration of D-dimer, a recognized biomarker of increasing blood clotting activity, through immunochemical biosensor comprising antibody captured onto the surface of impedimetric analysis electrodes.…”

Section: Microfluidics Devices For Biosensingmentioning

confidence: 99%

Microfluidic Systems for Biosensing

Liu

Chuang

et al. 2010

Sensors

100

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In the past two decades, Micro Fluidic Systems (MFS) have emerged as a powerful tool for biosensing, particularly in enriching and purifying molecules and cells in biological samples. Compared with conventional sensing techniques, distinctive advantages of using MFS for biomedicine include ultra-high sensitivity, higher throughput, in-situ monitoring and lower cost. This review aims to summarize the recent advancements in two major types of micro fluidic systems, continuous and discrete MFS, as well as their biomedical applications. The state-of-the-art of active and passive mechanisms of fluid manipulation for mixing, separation, purification and concentration will also be elaborated. Future trends of using MFS in detection at molecular or cellular level, especially in stem cell therapy, tissue engineering and regenerative medicine, are also prospected.

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A Novel Point of Care Diagnostic Device: Impedimetric Detection of a Biomarker in Whole Blood

Cited by 5 publications

References 34 publications

From Point-of-Care Testing to eHealth Diagnostic Devices (eDiagnostics)

From Point-of-Care Testing to eHealth Diagnostic Devices (eDiagnostics)

Emerging applications of nanomedicine for the diagnosis and treatment of cardiovascular diseases

Microfluidic Systems for Biosensing

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