Microfluidic Systems for Biosensing

Liu, Kuo-Kang; Wu, Ren-Guei; Chuang, Yun-Ju; Khoo, Hwa Seng; Huang, Shih-Hao; Tseng, Fan‐Gang

doi:10.3390/s100706623

Cited by 101 publications

(56 citation statements)

References 176 publications

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“…Because there are many beneficial size effects at the micro and nano scales, such as short mixing times, high efficiency in chemical reactions, and minute amounts of reagents and effluent liquids, micro/nano fluidic devices have been extensively studied for use in biomedical applications [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20]. In particular, nano fluidic devices that contain nano channels can be used for separation and filtration [21], single-molecule detection [22][23][24][25][26], highly efficient PCR [27], chemical analysis [28,29] and nano-photonic sensors [30], with great help of development of nanofabrication technologies [31][32][33][34][35][36][37][38][39][40][41][42][43].…”

Section: Introductionmentioning

confidence: 99%

Effects of Micromachining Processes on Electro-Osmotic Flow Mobility of Glass Surfaces

et al. 2013

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Silica glass is frequently used as a device material for micro/nano fluidic devices due to its excellent properties, such as transparency and chemical resistance. Wet etching by hydrofluoric acid and dry etching by neutral loop discharge (NLD) plasma etching are currently used to micromachine glass to form micro/nano fluidic channels. Electro-osmotic flow (EOF) is one of the most effective methods to drive liquids into the channels. EOF mobility is affected by a property of the micromachined glass surfaces, which includes surface roughness that is determined by the manufacturing processes. In this paper, we investigate the effect of micromaching processes on the glass surface topography and the EOF mobility. We prepared glass surfaces by either wet etching or by NLD plasma etching, investigated the surface topography using atomic force microscopy, and attempted to correlate it with EOF generated in the micro-channels of the machined glass. Experiments revealed that the EOF mobility strongly depends on the surface roughness, and therefore upon the fabrication process used. A particularly strong dependency was observed when the surface roughness was on the order of the electric double layer thickness or below. We believe that the correlation described in this paper can be of great help in the design of micro/nano fluidic devices.

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Section: Introductionmentioning

confidence: 99%

Effects of Micromachining Processes on Electro-Osmotic Flow Mobility of Glass Surfaces

et al. 2013

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“…Microfluidics can be seen as an enabling technology, allowing the sensing of decreasing sample volumes (Liu et al, 2010). The scaling down of dimensions allow for reduced reagent consumption, higher throughput, enhanced analytical performance, less waste, lower unit cost, and reduced energy consumption, all of which make it an appropriate technology for portable sensing devices (Squires and Quake, 2005).…”

Section: Low-cost Microfluidic Platforms For Use In Biosensingmentioning

confidence: 99%

Review: <i>Biosensors for the detection of Escherichia coli</i>

Maas

Perold

Dicks

2017

WSA

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The supply of safe potable water, free from pathogens and chemicals, requires routine analyses and the application of several diagnostic techniques. Apart from being expensive, many of the detection methods require trained personnel and are often time-consuming. With drastic climate changes, severe droughts, increases in population and pollution of natural water systems, the need to develop ultrasensitive, low-cost and hand-held, point-of-use detection kits to monitor water quality is critical. Although Escherichia coli is still considered the best indicator of water quality, cell numbers may be below detection limits, or the cells may be non-culturable and thus only detected by DNA amplification. A number of different biosensors have been developed to detect viable, dead or non-culturable microbial cells and chemicals in water. This review discusses the differences in these biosensors and evaluates the application of microfluidics in the design of ultra-sensitive nano-biosensors.

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“…The variation of the channel dimensions can regulate the droplet volumes and decrease volumes considerably, compared to the assays in conventional micro-titer plates. It is the convergence of these features and the ability to manipulate the droplet motions that provides a good approach to synthesis [16]. A flow-focusing microcapillary device showing the formation of droplets can be seen in Figure 4.…”

Section: Discrete Microfluidic Systemsmentioning

confidence: 99%

Microfluidics-Nano-Integration for Synthesis and Sensing

Bădilescu

Packirisamy

2012

Polymers

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Abstract:The recent progress and achievements in the development of preparation of nano and microparticles in a microfluidic environment is reviewed. Microfluidics exploit fluid mechanics to create particles with a narrow range of sizes and offers a finely controllable route to tune the shape and composition of nanomaterials. The advantages of both continuous flow-and droplet-based synthesis of polymers and nanoparticles, in comparison with the traditional stirred flasks methods are discussed in detail by using numerous recent examples from the literature as well as from the authors' work. The controllability of the size distribution of the particles is discussed in terms of the fabrication approach and the characteristics of the microfluidic reactors. A special attention is paid to metal-polymer nanocomposites prepared through microfluidic routes and their application in bio-sensing. Directions for future development of microfluidic synthesis of high quality nanoparticles are discussed.

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Microfluidic Systems for Biosensing

Cited by 101 publications

References 176 publications

Effects of Micromachining Processes on Electro-Osmotic Flow Mobility of Glass Surfaces

Effects of Micromachining Processes on Electro-Osmotic Flow Mobility of Glass Surfaces

Review: <i>Biosensors for the detection of Escherichia coli</i>

Microfluidics-Nano-Integration for Synthesis and Sensing

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