A novel phenol-bound pectic polysaccharide from<i>Decalepis hamiltonii</i>with multi-step ulcer preventive activity

Srikanta, BM; Siddaraju, M. N.; Dharmesh, SM

doi:10.3748/wjg.v13.i39.5196

Cited by 52 publications

(40 citation statements)

References 36 publications

(52 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In addition higher tannin content has been detected in RTE when compared with the level detected in Rhus oxyacantha fresh root bark extract (Tebourbi et al 2006). The chemical study of RTE also revealed the presence of polysaccharide content but appeared lower than that the level detected in swallow root known for their antiulcerogenic effect (Srikanta et al 2007). It has been demonstrated that phenolic, flavonoids, condensed tannins and polysaccharide possess an ideal structural chemistry for free radical scavenging activity which arise 1) from their high reactivity as hydrogen or electron donors, 2) from their ability to stabilize and delocalize the unpaired electron (chain-breaking function), and 3) from their potential to chelate metal ions (termination of the Fenton reaction) (Galati and O'Brien 2004;Chanda and Dave 2009;Zhong et al 2010).…”

Section: Discussionmentioning

confidence: 99%

“…In addition higher tannin content (57.53 ± 0.64 mg CE/g) have been detected in RTE when compared with the level (25.33 ± 0.07 mg CE/g) detected in fresh root bark extract of Rhus oxyacantha (Tebourbi et al 2006). Where as RTE polysaccharide content (126.78 ± 0.59 mg/g of extract) appeared lower then that the level (600 mg/ g of extract) detected in Decalepis hamiltonii root known for their antiulcerogenic effect (Srikanta et al 2007). …”

Section: Phytochemical Studies Of Rtementioning

confidence: 99%

See 1 more Smart Citation

Phytochemical, antioxidant and protective effect of Rhus tripartitum root bark extract against ethanol-induced ulcer in rats

Alimi¹,

Mbarki²,

Barka³

et al. 2013

gpb

View full text Add to dashboard Cite

Abstract. Rhus tripartitum (sumac) is an Anacardiaceae tree with a wide phytotherapeutic application including the use of its roots in the management of gastric ulcer. In the present study the Rhus tripartitum root barks extract (RTE) was phytochemical studied, in vitro tested for their potential antioxidant activity using 2,2-diphenyl-1-picrylhydrazyl (DPPH) and reducing power assay and in vivo evaluated for its ability to prevent ethanol-induced gastric ulcer in rats. The RTE was rich in phenolics, flavonoids, tannins and polysaccharide contents and exhibited a low but not weak in vitro antioxidant activity when compared with (+)-catechin. Pre-treatment with RTE at oral doses 50, 200 and 400 mg/kg body weight was found to provide a dose-dependent protection against ethanolinduced ulcer by averting the deep ulcer lesions of the gastric epithelium, by reducing gastric juice and acid output, by enhancing gastric mucus production by preserving normal antioxidant enzymes activities, and inhibiting the lipid peroxidation. The antiulcerogenic activity of RTE might be due to a possible synergistic antioxidant and antisecretory effects.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Phytochemical Studies Of Rtementioning

confidence: 99%

Phytochemical, antioxidant and protective effect of Rhus tripartitum root bark extract against ethanol-induced ulcer in rats

Alimi¹,

Mbarki²,

Barka³

et al. 2013

gpb

View full text Add to dashboard Cite

show abstract

“…Gastric ulcer is a widespread global problem in the modern era; it is estimated that around 14.5 million of the worldwide population is affected, with a mortality of 4.08 million [1]. The pervasiveness of gastric ulcer is due to behavioral and environmental factors such as inadequate dietary habits, smoking, excessive use of non-steroidal anti-inflammatory agents (NSAIDs), stress, hereditary predisposition, and infection with Helicobacter pylori [2,3].…”

Section: Introductionmentioning

confidence: 99%

Anti-Ulcer Study of Standardized Ethanol Root Extract of Aganosma Dichotoma and Isolated Ursolic Acid

Pandey

Joshi

Hemalatha

2017

Int J Pharm Pharm Sci

View full text Add to dashboard Cite

Objective: Aganosma dichotoma K. Schum (Apocynaceae) has been traditionally used as an Ayurvedic ulcer treatment and the study scientifically validates the antiulcer effect of A. dichotoma ethanol root extract (EAD). Methods:The studies included the isolation, quantification of ursolic acid through HPTLC. Acute and sub-acute toxicity study of EAD for 28 d and antiulcer effect of ursolic acid (50 mg/kg, p. o.), EAD (100, 200 and 400 mg/kg, p. o.) were also evaluated on both the physical (pyloric ligation, PL; cold restrain stress, CRS;) and chemical (absolute ethanol, aspirin, ASP;) induced ulcer in Charles Foster albino rats for 7 d. The various gastric-ulcer parameters, viz. gastric pH, volume, acid-pepsin output, DNA content, H + K + -ATPase activity, mucus content, microvascular permeability, antioxidant enzyme, and gastric histopathological study were performed. Results:The isolated ursolic acid was characterized by NMR and mass spectrometer and quantified through HPTLC in EAD (4.26% w/w). Acute oral toxicity study indicated that LD50 of extract was ≥ 5 g/kg. EAD at the dose of 200 and 400 mg/kg, p. o. reduced the ulcer score in both physical and chemical-induced ulcer models. In PL model EAD (400 mg/kg, p. o.) and ursolic acid (50 mg/kg, p. o.) showed antisecretory property by inhibiting aggressive factors [increase in gastric pH (35.02%, 26.73%), whereas decreased gastric volume (43.55%, 34.35%) and acid-pepsin output (75.23%, 68.81%), respectively]. EAD at 400 mg/kg p. o. showed significant effect on proton pump inhibition while ursolic acid didn't showed any effect. Conclusion:The effects of EAD were accredited mainly to the offensive mechanism and justify its traditional usage in the treatment of gastric ulcers.

show abstract

“…Such drugs include H 2 -blockers (Cimetidine, ranitidine), M 1 -blockers (porenzepine, telezepine), prostaglandin analogue (misoprostol), proton pump antagonists (omeprazole, lansoprazole), antacids (calcium tetraoxosulphate (iv) [CaSO 4 ], sodium hydrogen trioxocarbonate (iv) [NaHCO 3 ), triple drug therapy (to eradicate Helicobacter pylori). The successes of these drugs are limited by several adverse effects: darkening of the stool and/or tongue, metallic taste in the mouth, hypotension, loss of libido, impotence, relapse of the disease, drug resistance, constipation and nausea [3,4]. These shortcomings have led to the search for more effective therapeutic targets with better protection and decrease in incidence of relapse [5].…”

Section: Introductionmentioning

confidence: 99%

Antiulcerogenic Potentials of Fermented Aqueous Extract of <i>Pentaclethra macrophylla</i> (Benth) Seeds

Ugbogu¹,

Arunsi²,

O³

et al. 2017

AJBR

View full text Add to dashboard Cite

Pentaclethra macrophylla popularly known as African oil bean is a member of the Leguminosae family.A decoction of fermented extract of the plant has been known to be effective in the management of malnutrition, gastrointestinal disorders and dental caries. This study evaluated the antiulcerogenic potentials of aqueous extract of fermented P. macrophylla seeds using acetic acid, aspirin, ethanol, indomethacin and pyloric ligation of ethanol induced ulcer models at the doses of 400 and 800mg/kg body weight. Omeprazole at 5mg/kg was used as a standard reference drug. The result of the acute toxicity test showed that up to 5,000mg/kg body weight of the extract did not cause any mortality of the animals. The different doses of the extract and the reference drug decreased significantly (p<0.05) the ulcer parameters in a dose-dependent manner in all the ulcer models. The degree of ulcer index for the negative control groups is in the order: Indomethacin (11.10±0.10) < Pyloric-ligation (11.57±0.06) < Aspirin (11.60±0.10)

show abstract

A novel phenol-bound pectic polysaccharide fromDecalepis hamiltoniiwith multi-step ulcer preventive activity

Abstract: A I M : To i n v e s t i g a t e H + , K + -AT Pa s e i n h i b i t i o n ,anti-H pylori , antioxidant, and the in vivo antiulcer potential of a pectic polysaccharide from Swallow root (Decalepis hamiltonii ; SRPP).

Cited by 52 publications

References 36 publications

Phytochemical, antioxidant and protective effect of Rhus tripartitum root bark extract against ethanol-induced ulcer in rats

Phytochemical, antioxidant and protective effect of Rhus tripartitum root bark extract against ethanol-induced ulcer in rats

Anti-Ulcer Study of Standardized Ethanol Root Extract of Aganosma Dichotoma and Isolated Ursolic Acid

Antiulcerogenic Potentials of Fermented Aqueous Extract of <i>Pentaclethra macrophylla</i> (Benth) Seeds

Contact Info

Product

Resources

About

A novel phenol-bound pectic polysaccharide fromDecalepis hamiltoniiwith multi-step ulcer preventive activity

Abstract: A I M : To i n v e s t i g a t e H + , K + -AT Pa s e i n h i b i t i o n ,anti-H pylori , antioxidant, and the in vivo antiulcer potential of a pectic polysaccharide from Swallow root (Decalepis hamiltonii ; SRPP).

Cited by 52 publications

References 36 publications

Phytochemical, antioxidant and protective effect of Rhus tripartitum root bark extract against ethanol-induced ulcer in rats

Phytochemical, antioxidant and protective effect of Rhus tripartitum root bark extract against ethanol-induced ulcer in rats

Anti-Ulcer Study of Standardized Ethanol Root Extract of Aganosma Dichotoma and Isolated Ursolic Acid

Antiulcerogenic Potentials of Fermented Aqueous Extract of <i>Pentaclethra macrophylla</i> (Benth) Seeds

Contact Info

Product

Resources

About

Phytochemical, antioxidant and protective effect of Rhus tripartitum root bark extract against ethanol-induced ulcer in rats

Phytochemical, antioxidant and protective effect of Rhus tripartitum root bark extract against ethanol-induced ulcer in rats