A novel peptide-based fluorescent chemosensor for detection of zinc (II) and copper (II) through differential response and application in logic gate and bioimaging

Progress in the Development of Biosensors Based on Peptide–Copper Coordination Interaction

“…Therefore, exogenous fluorescent molecules or metal nanoclusters (NCs) are often used to modify peptides, including dansyl (Dns), carboxyl fluorescein (FAM), fluorescein isothiocyanate (FITC), and pyrene sulfonyl chloride (PySO 2 ) ( Table 1 ). Among them, dansyl is a commonly used fluorescent group to modify peptide for the detection of metal ions [ 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 ]. Meanwhile, the sulfonamide group in it can facilitate the formation of peptide–metal complexes [ 35 ].…”

“…Moreover, Wang et al synthesized a peptide fluorescent probe (dansyl-Gly-Cys-NH 2 , DGC) for the selective detection of Cu 2+ and Cd 2+ in aqueous solution and within live LNCaP cells [ 32 ]. At the same time, they designed and synthesized two dansyl-labeled fluorescent peptide probes (dansyl-Ser-Pro-Gly-His-NH 2 and dansyl-His-Pro-Gly-Glu-NH 2 ) for the “signal-on” detection of Zn 2+ and “signal-off” detection of Cu 2+ through two different mechanisms [ 30 , 33 ]. The detection limits for Zn 2+ and Cu 2+ are as low as 4.9 nM and 15 nM, respectively.…”

Synthesis and Photophysical Properties of Multi‐Functional Bisimidazolyl Phenol Zinc (II) Complex: Application in OLED, Anti‐Counterfeiting and Latent Finger Print Detection

“…[2] Besides, the π-conjugation of the ligand during the chelation to the metal atoms influences not only fluorescence properties but also the electron-accepting/transporting capability of the complex, from the ligand to the metal atom. [3,4] Zinc metal-complexes, an excellent luminescent and electronaccepting/transporting materials indispensable in the organic light-emitting device (OLEDs), [5] solar cells, [6] sensors, [7] bioimaging, [8] and latent fingerprint [9] (LFPs) applications. Imidazole and its derivatives are a significant class of compounds; upon suitable substitution, it can act as a ligand by coordinating to metal atoms.…”

Selective and Sensitive Discrimination of Zinc and Cadmium Based on a Novel Fluorescent Porous Organic Polymer

“…The balance of metal ions in ecosystem has been broken since the rapid development of industrialization, and numerous techniques for metal ions recognition have attracted wide attention of their important roles in human being and the environment. Zinc is the second most abundant transition metal on Earth and plays important roles in biological processes, such as gene expression, cellular metabolism and aerobic transport [1][2][3]. Abnormal metabolism of zinc ions will cause serious diseases including diabetes, epilepsy, prostate cancer, ischemic stroke and Alzheimer's disease [4][5][6].…”

“…Fluorescence methods with high sensitivity, rapidity and costsaving have become one of the best solutions to the above problems [12][13][14][15][16][17]. Until now, various fluorescence probe have been reported for Zn 2+ and Cd 2+ detection, such as naphthalimide-derived fluorophore [18], DNAzyme [19], quinoline derivatives [20,21], diarylethene derivatives [22], cephem-based probe [23] and dansyl-appended tetrapeptide [1]. The reported fluorescence methods normally detect Zn 2+ or Cd 2+ based on fluorescence changes induced by the coordination of Zn 2+ or Cd 2+ with probes, however, the selectivity towards Zn 2+ or Cd 2+ are insufficient since the two metal ions have similar electron configuration and coordination features and both of them can simultaneously coordinated with fluorescence probes [24].…”