Progress in the Development of Biosensors Based on Peptide–Copper Coordination Interaction

Liu, Gang; Xia, Ning; Tian, Linxu; Sun, Zhifang; Liu, Lin

doi:10.3390/bios12100809

Cited by 9 publications

(7 citation statements)

References 88 publications

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“…Therefore, further research is still needed to clarify the specific affinity structure and ligand for arsenic. (6) Copper: A common feature of various ligands used to detect copper ions is their nitrogen-based imidazole, pyrrole, and porphyrin derivatives, including 2-mercaptobenzimidazole, benzimidazole, , guanine, and histidine (Figure f). , The color change is induced through a coordination bond with a lone pair of electrons in nitrogen. Studies have shown that copper tends to bind with N-terminal amyloid beta proteins, and nanoparticle aggregation methods using them have also been studied .…”

Section: Discussionmentioning

confidence: 99%

Gold Nanoparticles as Exquisite Colorimetric Transducers for Water Pollutant Detection

Cho

Jung

Heo

et al. 2023

ACS Appl. Mater. Interfaces

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Gold nanoparticles (AuNPs) are useful nanomaterials as transducers for colorimetric sensors because of their high extinction coefficient and ability to change color depending on aggregation status. Therefore, over the past few decades, AuNP-based colorimetric sensors have been widely applied in several environmental and biological applications, including the detection of water pollutants. According to various studies, water pollutants are classified into heavy metals or cationic metal ions, toxins, and pesticides. Notably, many researchers have been interested in AuNP that detect water pollutants with high sensitivity and selectivity, while offering no adverse environmental issues in terms of AuNP use. This review provides a representative overview of AuNP-based colorimetric sensors for detecting several water pollutants. In particular, we emphasize the advantages of AuNP as colorimetric transducers for water pollutant detection in terms of their low toxicity, high stability, facile processability, and unique optical properties. Next, we discuss the status quo and future prospects of AuNP-based colorimetric sensors for the detection of water pollutants. We believe that this review will promote research and development of AuNP as next-generation colorimetric transducers for water pollutant detection.

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Section: Discussionmentioning

confidence: 99%

Gold Nanoparticles as Exquisite Colorimetric Transducers for Water Pollutant Detection

Cho

Jung

Heo

et al. 2023

ACS Appl. Mater. Interfaces

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“…Despite the wide applications of natural enzymes, they still have several drawbacks, including poor environmental stability, high cost, difficulty in storage, and strict working conditions. To address these limitations, artificial enzymes have been exploited to mimic natural enzymes more effectively, including organic molecules, organic complexes, DNAzymes, and nanomaterials with enzyme-like characteristics (i.e., nanozymes) [ 169 , 170 , 171 ]. These artificial enzymes have been widely used to construct electrochemical biosensors for the quantitative detection of disease biomarkers [ 172 , 173 , 174 ].…”

Section: Oxidoreductases As the Signal Labels Of Electrochemical Immu...mentioning

confidence: 99%

Overview on the Development of Electrochemical Immunosensors by the Signal Amplification of Enzyme- or Nanozyme-Based Catalysis Plus Redox Cycling

Xia,

Gao,

Zhang

et al. 2024

Molecules

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Enzyme-linked electrochemical immunosensors have attracted considerable attention for the sensitive and selective detection of various targets in clinical diagnosis, food quality control, and environmental analysis. In order to improve the performances of conventional immunoassays, significant efforts have been made to couple enzyme-linked or nanozyme-based catalysis and redox cycling for signal amplification. The current review summarizes the recent advances in the development of enzyme- or nanozyme-based electrochemical immunosensors with redox cycling for signal amplification. The special features of redox cycling reactions and their synergistic functions in signal amplification are discussed. Additionally, the current challenges and future directions of enzyme- or nanozyme-based electrochemical immunosensors with redox cycling are addressed.

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“…The Cu element is one of the necessary metal elements for living things and serves as a cofactor or active center in some natural enzymes such as laccase, uricase, hemocyanin, and azurin. , Nitrogen-doped carbon-supported Cu single-atom catalysts with isolated Cu active sites have a similar chemical structure and might exhibit enzyme-mimicking properties. In this study, we demonstrated a facile and effective strategy for the preparation of a nitrogen-doped carbon-supported Cu single-atom (Cu-SAC) nanozyme, which exhibited excellent peroxidase-like activity.…”

Section: Introductionmentioning

confidence: 99%

Facile Synthesis of High-Loading Cu Single-Atom Nanozyme for Total Antioxidant Capacity Sensing

Liu,

Wu,

Zheng

et al. 2023

ACS Appl. Nano Mater.

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Single-atom catalysts (SACs) with atomically dispersed active sites and maximum atomic utilization efficiency provide new opportunities to develop high-performance nanozymes. However, the preparation of SACs with a high metal content still faces serious challenges. Herein, we report a pyrolysis method for achieving a Cu single-atom catalyst (Cu-SAC) on nitrogen-doped carbon with a Cu loading of 7.98 wt %. Isolated Cu atoms with Cu–N3–C coordination were confirmed by spherical aberration-corrected transmission electron microscopy and X-ray absorption spectroscopy. The synthesized Cu-SAC displayed outstanding peroxidase-like activity by effectively catalyzing the reaction between 3,3′,5,5′-tetramethylbenzidine (TMB) and H2O2 to show a blue color. Based on the inhibition effect on the oxidation of TMB by ascorbic acid (AA), a colorimetric assay for AA was established with a limit of detection (LOD) of 0.63 μM. Furthermore, the total antioxidant capacities (TACs) of practical samples including vitamin C tablets, commercial beverages, and fresh fruit were successfully detected by the proposed colorimetric assay. This study provided a facile method for the preparation of high-metal-loading SACs, which exhibited high enzymatic properties with promising applications in food and drug safety.

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Progress in the Development of Biosensors Based on Peptide–Copper Coordination Interaction

Cited by 9 publications

References 88 publications

Gold Nanoparticles as Exquisite Colorimetric Transducers for Water Pollutant Detection

Gold Nanoparticles as Exquisite Colorimetric Transducers for Water Pollutant Detection

Overview on the Development of Electrochemical Immunosensors by the Signal Amplification of Enzyme- or Nanozyme-Based Catalysis Plus Redox Cycling

Facile Synthesis of High-Loading Cu Single-Atom Nanozyme for Total Antioxidant Capacity Sensing

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