A novel open‐tubular capillary electrochromatography using carboxymethyl‐β‐cyclodextrin functionalized gold nanoparticles as chiral stationary phase

Zhang, Chenning; Qu, Jialin; Lv, Xiaoyuan; Fang, Linlin

doi:10.1002/jssc.201900733

Cited by 16 publications

(15 citation statements)

References 21 publications

(25 reference statements)

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“…Their work was validated by separation of six amino acid enantiomers. Finally, Zhang et al reported in 2019 the development of chiral OT-CEC with a stationary phase of modified β-CDs conjugated to gold nanoparticles [236]. After optimizing the conditions, they showed the enantioselective separation of tramadol hydrochloride and zopiclone with high resolution.…”

Section: Chiral Open-tubular Cecmentioning

confidence: 99%

Past, present, and future developments in enantioselective analysis using capillary electromigration techniques

2020

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Past, present, and future developments in enantioselective analysis using capillary electromigration techniques Enantioseparation of chiral products has become increasingly important in a large diversity of academic and industrial applications. The separation of chiral compounds is inherently challenging and thus requires a suitable analytical technique that can achieve high resolution and sensitivity. In this context, CE has shown remarkable results so far. Chiral CE offers an orthogonal enantioselectivity and is typically considered less costly than chromatographic techniques, since only minute amounts of chiral selectors are needed. Several CE approaches have been developed for chiral analysis, including chiral EKC and chiral CEC. Enantioseparations by EKC benefit from the wide variety of possible pseudostationary phases that can be employed. Chiral CEC, on the other hand, combines chromatographic separation principles with the bulk fluid movement of CE, benefitting from reduced band broadening as compared to pressure-driven systems. Although UV detection is conventionally used for these approaches, MS can also be considered. CE-MS represents a promising alternative due to the increased sensitivity and selectivity, enabling the chiral analysis of complex samples. The potential contamination of the MS ion source in EKC-MS can be overcome using partial-filling and counter-migration techniques. However, chiral analysis using monolithic and open-tubular CEC-MS awaits additional method validation and a dedicated commercial interface. Further efforts in chiral CE are expected toward the improvement of existing techniques, the development of novel pseudostationary phases, and establishing the use of chiral ionic liquids, molecular imprinted polymers, and metalorganic frameworks. These developments will certainly foster the adoption of CE(-MS) as a well-established technique in routine chiral analysis.

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Section: Chiral Open-tubular Cecmentioning

confidence: 99%

Past, present, and future developments in enantioselective analysis using capillary electromigration techniques

2020

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“…Nonetheless, although it is highly difficult to compare directly the separation resolution between different analytes and columns, the effectiveness of each strategy is evident whereby in optimised conditions (i. e. pH, buffer concentrations, applied voltages, selected analyte, etc.) the separation resolutions are often well above 2.0, sometimes reaching above 4.0 . Furthermore, within the vast majority of listed published articles, the authors frequently analyse the stability of prepared columns and techniques extensively, along with adjustments to the methods, including changes to the polarity and pH of the mobile phase, for more in‐depth analysis of interactions and enantioseparation.…”

Section: Cyclodextrin Functionalised Nanomaterials In Chiral Recognitionmentioning

confidence: 99%

Cyclodextrin‐Functionalised Nanomaterials for Enantiomeric Recognition

Hobbs

Řezanka

2020

ChemPlusChem

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which are glucose-based cyclic oligosaccharides, are materials that can act inherently as chiral selectors, with many reports of the application of cyclodextrins in enantioseparation. However, many studies have encountered the problem of insufficient enantioselective performance of the chiral selector. One of the main reasons is due to low surface concertation's, whereby interaction between the chiral selector and analyte usually occurs at a surface. Thus, scientists have been trying for the last two decades to overcome this problem, with the incorporation of nanomaterials being promising as they possess a large surface area which allows for the accommodation of a higher concentration of the chiral selectors. Herein, we outline nanomaterial-cyclodextrin conjugates that work in tandem to achieve or enhance enantioselectivity through various methods such as chromatography, adsorption, and removal using magnetic nanoparticles, or enantiorecognition using electrochemical techniques.

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“…Ji's group successfully prepared of β-cyclodextrin covalent organic framework modified chiral stationary phase for separation of six enantiomers [21]. Fang et al developed an OT-CEC column using carboxymethyl-βcyclodextrin functionalized gold nanoparticles as chiral stationary phase [22]. Li also prepared β-cyclodextrin functionalized periodic mesoporous organosilica open tubular capillary columns for separating amino acid enantiomer derivatives [23].…”

Section: Introductionmentioning

confidence: 99%

“…Fang et al. developed an OT‐CEC column using carboxymethyl‐β‐cyclodextrin functionalized gold nanoparticles as chiral stationary phase [22]. Li also prepared β‐cyclodextrin functionalized periodic mesoporous organosilica open tubular capillary columns for separating amino acid enantiomer derivatives [23].…”

Section: Introductionmentioning

confidence: 99%

Open tubular capillary column immobilized with sulfobutylether‐β‐cyclodextrin for chiral separation in capillary electrochromatography

Zhou

2021

J of Separation Science

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A novel chiral open tubular capillary column was fabricated with sulfobutylether-β-cyclodextrin and glycidyl methacrylate for enantioseparation in capillary electrochromatography. First, the pretreated silica-fused capillary was treated with 3-trimethoxysilyl propyl methacrylate to attach double bond ligand onto the surface. A copolymer layer was formed on the surface of capillary using glycidyl methacrylate and ethylene dimethacrylate by in situ one-pot polymerization. Sulfobutylether-β-cyclodextrin was encapsulated inside the copolymerized layer. The morphology of the developed column was characterized by field emission scanning electron microscopy. The effect of organic percentage and pH value of the mobile phase on electroosmotic flow and resolution was also investigated. The performance of the fabricated column was validated by separation of amlodipine besilate, 2,3-diphenylpropionic acid, tropic acid, and pantoprazole enantiomers with good resolutions of 3.67, 4.82, 3.34, and 2.61, respectively. The repeatabilities of column-to-column and day-today through relative standard deviation were found better than 4%, exhibiting satisfactory repeatability of the developed column. The results reveal that open tubular capillary columns modified with β-cyclodextrin show a great prospect for enantioseparation of chiral drugs in capillary electrochromatography.

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A novel open‐tubular capillary electrochromatography using carboxymethyl‐β‐cyclodextrin functionalized gold nanoparticles as chiral stationary phase

Cited by 16 publications

References 21 publications

Past, present, and future developments in enantioselective analysis using capillary electromigration techniques

Past, present, and future developments in enantioselective analysis using capillary electromigration techniques

Cyclodextrin‐Functionalised Nanomaterials for Enantiomeric Recognition

Open tubular capillary column immobilized with sulfobutylether‐β‐cyclodextrin for chiral separation in capillary electrochromatography

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