Understanding the molecular mechanisms underlying gastric cancer progression contributes to the development of novel targeted therapies. In this study, we found that the expression levels of miR-125b were strongly downregulated in gastric cancer and associated with clinical stage and the presence of lymph node metastases. Additionally, miR-125b could independently predict OS and DFS in gastric cancer. We further found that upregulation of miR-125b inhibited the proliferation and metastasis of gastric cancer cells in vitro and in vivo. miR-125b elicits these responses by directly targeting MCL1 (myeloid cell leukemia 1), which results in a marked reduction in MCL1 expression. Transfection of miR-125b sensitizes gastric cancer cells to 5-FU-induced apoptosis. By understanding the function and molecular mechanisms of miR-125b in gastric cancer, we may learn that miR-125b has the therapeutic potential to suppress gastric cancer progression and increase drug sensitivity to gastric cancer.
Enantioselective open tubular capillary electrochromatography with carboxymethyl‐β‐cyclodextrin conjugated gold nanoparticles as stationary phase was developed. This novel open tubular column was fabricated through layer‐by‐layer self‐assembly of gold nanoparticles on a 3‐mercaptopropyl‐trimethoxysilane‐modified fused‐silica capillary and subsequent surface functionalization of the gold nanoparticles through self‐assembly of 6‐mercapto‐β‐cyclodextrin. The 6‐mercapto‐β‐cyclodextrin was firstly synthesized and determined by extensive spectroscopic data. Scanning electron microscopy, energy dispersive X‐ray analysis spectroscopy, and electroosmotic flow experiments were carried out to characterize the prepared open tubular column. Then, the separation effectiveness of the open tubular column was verified by two pairs of ɑ‐tetralones derivatives enantiomers and two pairs of basic drug enantiomers (tramadol hydrochloride and zopiclone) as mode analytes. Factors that influence the enantioseparation were optimized, and under the optimized conditions, satisfactory separation results were obtained for the four enantiomers: compound A, compound B, tramadol hydrochloride, and zopiclone with resolutions of 3.79, 1.56, 1.03, 1.60, respectively. For the combination of gold nanoparticles and negatively charged carboxymethyl‐β‐cyclodextrin, the open tubular column exhibited wider separation range for neutral and basic drugs. Moreover, the repeatability and stability of the column were studied through the run‐to‐run and day‐to‐day investigations.
With the exhaustion of conventional fossil fuels, the exploration of green and sustainable energy will become an important topic of social development. Hydrogen is considered a clean and effective energy source, and its combustion produces only water, which is harmless to the environment. Photocatalytic water splitting, which utilizes solar energy and produces H 2 and O 2 , can become a very important reaction for alleviating energy shortages and environmental pollution. Water splitting includes the reduction and oxidation half-reactions, among which the oxidation half-reaction is the rate-determining process. Even though current studies mainly focus on the H 2 or O 2 evolution reactions in the presence of sacrificial agents, overall water splitting remains a challenging problem. Metal-organic frameworks (MOFs) and their precursors have been attracting increasing attention as photocatalysts for water splitting. This paper reviews the research progress in MOFs for photocatalytic overall water splitting and discusses the development prospects and challenges of MOFs. In this study, the research progress in MOF-based watersplitting catalysts for photocatalysis and electrocatalysis is systematically reviewed. Herein, MOF-based catalysts are classified into MOFs, MOF composites, and MOF-derived photocatalysts. We also analyze the prospects and challenges in the preparation of efficient and stable MOF photocatalysts for overall water splitting and propose the construction of new efficient MOFs with double active sites, aiming to improve the efficiency of photocatalytic hydrogen and oxygen evolution to achieve the overall water splitting.
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