A novel one pot synthesis of nitrogen containing heterocycles: an alternate methodology to the Biginelli and Hantzsch reactions

Kidwai, Mazaahir; Saxena, Shilpi; Mohan, Richa; Venkataramanan, R.

doi:10.1039/b205539m

Cited by 113 publications

(45 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…16 But these generally afford pyrimidinone derivatives. In the present communication, we describe the MW accelerated solid supported synthesis of 4,6-diaryl-2-(4-morpholinyl/1-piperidinyl/1-pyrrolidinyl)-pyrimidines (3a-l).…”

Section: Resultsmentioning

confidence: 99%

Base Catalysed Pyrimidine Synthesis Using Microwave

2003

Bulletin of the Korean Chemical Society

View full text Add to dashboard Cite

An environmentally benign approach for the synthesis of 2-substituted-4,6-diaryl pyrimidines using inorganic solid supports for its catalytic role as well as an energy transfer medium is described. The methodology eliminates the usage of solvent during the reaction. The reaction time is brought down from hours to minutes along with yield enhancement. The rate enhancement and high yield is attributed to the coupling of solvent free conditions with microwaves. Further, the role of base is studied in the reaction and it is concluded that microwave assisted basic alumina catalysed reaction is the best in terms of catalysis as well as reaction time and yield.

show abstract

Section: Resultsmentioning

confidence: 99%

Base Catalysed Pyrimidine Synthesis Using Microwave

2003

Bulletin of the Korean Chemical Society

View full text Add to dashboard Cite

show abstract

“…In continuation of our earlier work on microwave synthesis 16 and with respect to the advantage of coupling, solvent free conditions 17 with microwave irradiation (MWI), equimolar amounts of neat reactants were mixed and irradiated under microwaves. This proved to be a high-yielding protocol (Table 1).…”

Section: Resultsmentioning

confidence: 99%

Niementowski reaction: microwave induced and conventional synthesis of quinazolinone and 3-methyl-1H-5-pyrazolone and their antimicrobial activity

Desai¹,

Desai²

2005

Arkivoc

View full text Add to dashboard Cite

The Niementowski reaction has been extended to synthesize 3-substituted/2,3-disubstituted-4(3H) quinazolinones instead of the 2-substituted derivatives. The methodology is environmentally benign and completely eliminates the need of solvent for the reaction. Neat reactants were cyclocondensed under microwaves to afford, in good yield, the desired product in less irradiation time as compared to the classical technique. The compared results of microwave and conventional techniques have been discussed. 3-Methyl-1H-pyrazolones were synthesized from substituted hydrazides using various solid supports under microwave irradiation (MWI). The results obtained highlight the versatility of the solid supports. All synthesized compounds were screened for their antibacterial activity against gram positive and gram negative bacteria and showed good to significant activity, as well as demonstrated significant antifungal activity against Candida albicans ATCC 10231 and C. krusei GO3.

show abstract

“…This, however, resulted in charring. In continuation of our earlier work on microwave assisted synthesis 18 and with respect to the advantage of coupling, solvent free conditions 19 with microwave irradiation (MWI), equimolar amounts of neat reactants were mixed and irradiated under microwaves. 20 This proved to be a high-yielding protocol (Table I).…”

Section: Resultsmentioning

confidence: 99%