Base Catalysed Pyrimidine Synthesis Using Microwave

Abstract

An environmentally benign approach for the synthesis of 2-substituted-4,6-diaryl pyrimidines using inorganic solid supports for its catalytic role as well as an energy transfer medium is described. The methodology eliminates the usage of solvent during the reaction. The reaction time is brought down from hours to minutes along with yield enhancement. The rate enhancement and high yield is attributed to the coupling of solvent free conditions with microwaves. Further, the role of base is studied in the reaction and it is concluded that microwave assisted basic alumina catalysed reaction is the best in terms of catalysis as well as reaction time and yield.

Microwave-Assisted Solution-Phase Parallel Synthesis of 2,4,6-Trisubstituted Pyrimidines

“…The desired product was obtained by the tag cleavage under microwave irradiation. Kidwai et al described a microwave-accelerated, one-pot, solid-supported synthesis of 4,6-diaryl-2-(4-morpholinyl/1-piperidinyl/1-pyrrolidinyl)-pyrimidines by the reaction of chalcone with S -benzylthiuronium chloride and heterocyclic secondary amines. Varga et al investigated the reaction of chalcones and guanidine.…”