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Modified Biginelli and Hantzsch reactions were carried using environmentally benign processes. Neat reactants subjected to microwave radiation gave the required products more quickly and in better yields in comparison to traditional methodologies. The observed yields and enhancement in reaction rates are due to the solvent free conditions coupled with the use of microwave radiation.

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The drive towards clean technology in the chemical industry with an increasing emphasis on the reduction of waste at source requires a level of innovation and new technology that the chemical industry is beginning to adopt. The green chemistry revolution provides an enormous number of opportunities to discover and apply new synthetic approaches using alternative feedstocks; ecofriendly reaction conditions, energy minimizations and the design of less toxic and inherently safer chemicals.

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The Niementowski reaction has been extended to synthesize 3-substituted/2,3-disubstituted-4(3H)quinazolinones instead of the 2-substituted derivatives. The methodology is environmentally benign and completely eliminates the need of solvent from the reaction. Neat reactants were cyclocondensed under microwaves to afford, in good yield, the desired product in less irradiation time as compared to the classical technique. The reaction time was reduced from hours to minutes along with yield enhancement. The rate enhancement and high yield are attributed to the coupling of solvent-free conditions with microwaves.

Microwave (MW) assisted synthesis of acridine and quinazoline derivatives was performed on thin layer chromatography (TLC) plates. This versatile, simple and economical green methodology is readily amenable to parallel synthesis of acridine and quinazoline compound libraries.

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