A novel multilayer hydrogel wound dressing for antibiotic release

Tamahkar, Emel; Özkahraman, Bengi; Süloğlu, Aysun Kılıç; İdil, Neslihan; Perçin, Işık

doi:10.1016/j.jddst.2020.101536

Cited by 52 publications

(46 citation statements)

References 32 publications

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“…The task of the lower layer was to remove exudate from the wound and to control the release of antibiotics placed in the middle layer. The multilayer hydrogels obtained showed a high application potential [ 9 ].…”

Section: Introductionmentioning

confidence: 99%

Physicochemical Investigations of Chitosan-Based Hydrogels Containing Aloe Vera Designed for Biomedical Use

et al. 2020

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In this work, synthesis and investigations on chitosan-based hydrogels modified with Aloe vera juice are presented. These materials were synthesized by UV radiation. Investigations involved analysis of chemical structure by FTIR spectroscopy, sorption properties in physiological liquids, strength properties by texture analyzer, surface topography by Atomic Force Microscopy (AFM technique), and in vitro cytotoxicity by MTT test using L929 murine fibroblasts. Particular attention was focused both on determining the impact of the amount and the molecular weight of the crosslinker used for the synthesis as well as on the introduced additive on the properties of hydrogels. It was proven that modified hydrogels exhibited higher swelling ability. Introduced additive affected the tensile strength of hydrogels—modified materials showed 23% higher elongation. The greater amount of the crosslinker used in the synthesis, the more compact the structure, leading to the lower elasticity and lower sorption of hydrogels was reported. Above 95%, murine fibroblasts remained viable after 24 h incubation with hydrogels. It indicates that tested materials did not exhibit cytotoxicity toward these lines. Additionally, materials with Aloe vera juice were characterized by lower surface roughness. Conducted investigations allowed us to state that such modified hydrogels may be considered as useful for biomedical purposes.

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Section: Introductionmentioning

confidence: 99%

Physicochemical Investigations of Chitosan-Based Hydrogels Containing Aloe Vera Designed for Biomedical Use

et al. 2020

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“…The cumulative ampicillin release from the multilayer hydrogels was achieved for 5 days resulting in significant antibacterial performance against SA (c). Reprinted with permission from 81 . Copyright 2020, Elsevier B.V…”

Section: Antibioticsmentioning

confidence: 99%

“…The HyA layer incorporated with ampicillin molecules was utilized for the antibiotic delivery through the wound area. The resultant multilayer dressings showed the release of ampicillin (63%) for 5 days with the high antibacterial activity against SA 81 . Ozdabak‐Sert prepared CS‐based two‐layered sponge incorporated with gelatin microspheres loaded with ibuprofen as the pain reliever and gentamicin or ciprofloxacin as the antibiotic.…”

Section: Antibioticsmentioning

confidence: 99%

“…For the effective treatment of the wound infections, the initial burst release, which means the release of about 60% of the loaded drug molecules during the first 5 hr is required followed by the controlled release. 69,70 In the literature, the antibiotics that were generally utilized for antibacterial wound dressing were summarized as gentamicin, 71,72 ciprofloxacin, 25,73 tetracycline, 74,75 and ampicillin. 76 In the Figure 3a, the schematic preparation route of a novel wound dressing using silk incorporated with gold nanoparticles with subsequent loading of gentamicin sulfate was demonstrated.…”

Section: Antibioticsmentioning

confidence: 99%

“…Reprinted with permission from. 81 Copyright 2020, Elsevier B.V nanoparticles for reducing the amount of the antibiotics to prevent any risk of antibiotic overuse. Also the inhibition zone images of the gentamicin-free (i, iii) and gentamicin-loaded fibers (ii, iv) against EC and SA were shown presenting the antibacterial activity only due to the gentamicin loading to the fibers with the improvement of antibacterial performance according to the integration of the gold nanoparticles.…”

Section: Antibioticsmentioning

confidence: 99%

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Advancements and future directions in the antibacterial wound dressings – A review

et al. 2020

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Wound repair is a complex process that has not been entirely understood. It can conclude in several irregularities. Hence, designing an appropriate wound dressing that can accelerate the healing period is critical. Infections, a major obstacle to wound repair, cause an elevated inflammatory responses and result in ultimate outcome of incomplete and prolonged wound repair. To overcome these shortcomings, there is a growing requirement for antibacterial wound dressings. Dressings with antibacterial activities and multifunctional behaviors are highly anticipated to avoid the wound infection for successful healing. The aim of this review is not only to concentrate on the importance of antibacterial dressings for wound healing applications but also to discuss recent studies and some future perspectives about antibacterial wound dressings.

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Production and Application of Biomaterials Based on Polyvinyl alcohol (PVA) as Wound Dressing

Jin

2022

Chemistry An Asian Journal

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The development of ideal wound dressing with excellent properties, such as exudate absorption capacity, drug release control ability, and increased wound healing, is currently a major requirement for wound healing. Polyvinyl alcohol (PVA) is a biodegradable semi‐crystalline synthetic polymer that has been used in the field of biotechnology such as tissue regeneration, wound dressing, and drug delivery systems. In recent years, PVA‐based wound dressing materials have received considerable attention due to their excellent properties such as biodegradability, biocompatibility, non‐toxicity and low cost. PVA can be used as a wound dressing material to create the necessary moist wound environment, improve the physical properties of the dressing, and increase the wound healing rates. In addition, PVA can also be mixed with other organic and inorganic materials and can be used for drug delivery and wound healing. This review article addresses the role of biomaterials based on PVA mixed with other ingredients for wound dressing. It also focuses on its recent use in wound dressings as carriers of active substances.

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A novel multilayer hydrogel wound dressing for antibiotic release

Cited by 52 publications

References 32 publications

Physicochemical Investigations of Chitosan-Based Hydrogels Containing Aloe Vera Designed for Biomedical Use

Physicochemical Investigations of Chitosan-Based Hydrogels Containing Aloe Vera Designed for Biomedical Use

Advancements and future directions in the antibacterial wound dressings – A review

Production and Application of Biomaterials Based on Polyvinyl alcohol (PVA) as Wound Dressing

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