A Novel Microwave Sensor to Detect Specific Biomarkers in Human Cerebrospinal Fluid and Their Relationship to Cellular Ischemia During Thoracoabdominal Aortic Aneurysm Repair

Fok, Matthew; Bashir, Mohamad; Fraser, Holly; Strouther, Nicholas; Mason, Alex

doi:10.1007/s10916-015-0208-4

Cited by 26 publications

(9 citation statements)

References 31 publications

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“…Although the exact values of the parameters are not known, this trend can be estimated in circuit simulation (Figure 6.10). This kind of correlation between S-parameter and glucose concentration has also been proven experimentally in several literature [159,163,[167][168][169].…”

Section: Sensor Design and Theorysupporting

confidence: 69%

Photoacoustic technique for noninvasive glucose sensing : principles and implementations

Zhang¹

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Section: Sensor Design and Theorysupporting

confidence: 69%

Photoacoustic technique for noninvasive glucose sensing : principles and implementations

Zhang¹

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“…The tetravalent streptavidin-biotin method used in this research yielded a good output and can be utilized for other biomarker analyses. Interdigitated electrode 0-2 V (current-volt) Immunosensing At low picomolar Dose-dependent analysis [33] Ultrasonic transducer 40 kHz Oscillator 2 to 400 cm Distance traveled [34] Telemetric pressure 95-130 mmHg Intra-aortic pressure 10 cm Transmission range [35] Telemetric pressure 133 kHz Operating frequency 120 mm Transmission range [36] Wireless pressure 10-20 MHz Operating frequency 40.27 kHz/mmHg Resonant frequency [37] Interdigitated electrode microwave 24 GHz Operating frequency 200 MHz and 4 GHz Frequency [38] Interdigitated electrode 0-2 V (current-volt) Duplex formation At low femtomolar Dose-dependent analysis Current work…”

Section: Discussionmentioning

confidence: 99%

Detection of microRNA-335-5p on an Interdigitated Electrode Surface for Determination of the Severity of Abdominal Aortic Aneurysms

Liu

Wang

et al. 2020

Nanoscale Res Lett

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Abdominal aortic aneurysm (AAA) refers to the enlargement of the lower artery of the abdominal aorta, and identification of an early detection tool is urgently needed for diagnosis. In the current study, an interdigitated electrode (IDE) sensing surface was used to identify miRNA-335-5p, which reflects the formation of AAAs. The uniformity of the silica material was observed by 3D profilometry, and the chemically modified highly conductive surface improved the detection via the I-V mode. The targeted miRNA-335-5p was detected in a dose-dependent manner and based on linear regression and 3σ analyses, the sensitivity was determined to be 1 fM with a biotinylated probe. The high specificity was shown by discriminating the target sequence from noncomplementary and single-and triple-mismatched sequences. These outputs demonstrated the high-performance detection of miRNA-335-5p with good reproducibility for determination of the severity of AAA.

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“…Examples of the design and use of microfluidic sensors in the microwave range can be found in the works of [ 380 , 381 , 382 ]. In [ 380 ], a microwave method and a dielectric resonator-microfluidic system for non-destructive determination of hemoglobin concentration in microliter blood samples are described, where a connection between the dielectric properties of mouse blood and the concentration of hemoglobin is established using broadband microwave spectroscopy (from 200 MHz to 40 GHz).…”

Section: Impedance Spectroscopy Microfluidic Techniques and Methods F...mentioning

confidence: 99%

“…In [ 381 ], the study’s authors demonstrated a symmetrical split ring resonator-based microwave sensor with spurline filters for detecting and characterizing the properties of drugs. In [ 382 ], they used an interdigitated electrode sensor and showed that it is capable of detecting various concentrations of albumin (from 0 to 100 g/L) with a high degree of repeatability at 200 MHz and 4 GHz.…”

Section: Impedance Spectroscopy Microfluidic Techniques and Methods F...mentioning

confidence: 99%

Label-Free Physical Techniques and Methodologies for Proteins Detection in Microfluidic Biosensor Structures

et al. 2022

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Proteins in biological fluids (blood, urine, cerebrospinal fluid) are important biomarkers of various pathological conditions. Protein biomarkers detection and quantification have been proven to be an indispensable diagnostic tool in clinical practice. There is a growing tendency towards using portable diagnostic biosensor devices for point-of-care (POC) analysis based on microfluidic technology as an alternative to conventional laboratory protein assays. In contrast to universally accepted analytical methods involving protein labeling, label-free approaches often allow the development of biosensors with minimal requirements for sample preparation by omitting expensive labelling reagents. The aim of the present work is to review the variety of physical label-free techniques of protein detection and characterization which are suitable for application in micro-fluidic structures and analyze the technological and material aspects of label-free biosensors that implement these methods. The most widely used optical and impedance spectroscopy techniques: absorption, fluorescence, surface plasmon resonance, Raman scattering, and interferometry, as well as new trends in photonics are reviewed. The challenges of materials selection, surfaces tailoring in microfluidic structures, and enhancement of the sensitivity and miniaturization of biosensor systems are discussed. The review provides an overview for current advances and future trends in microfluidics integrated technologies for label-free protein biomarkers detection and discusses existing challenges and a way towards novel solutions.

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A Novel Microwave Sensor to Detect Specific Biomarkers in Human Cerebrospinal Fluid and Their Relationship to Cellular Ischemia During Thoracoabdominal Aortic Aneurysm Repair

Cited by 26 publications

References 31 publications

Photoacoustic technique for noninvasive glucose sensing : principles and implementations

Photoacoustic technique for noninvasive glucose sensing : principles and implementations

Detection of microRNA-335-5p on an Interdigitated Electrode Surface for Determination of the Severity of Abdominal Aortic Aneurysms

Label-Free Physical Techniques and Methodologies for Proteins Detection in Microfluidic Biosensor Structures

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