A novel micropump droplet generator for aerosol drug delivery: Design simulations

Su, Guoguang; Longest, P. Worth; Pidaparti, Ramana M.

doi:10.1063/1.3517231

Cited by 22 publications

(14 citation statements)

References 45 publications

(57 reference statements)

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“…It can also be observed that uniform droplets are ejecting from the outlet of the device. More results with design variations of the microdevice can be found in Su, Longest, and Pidaparti [ 20 ].…”

Section: Resultsmentioning

confidence: 99%

“…The continuum surface force (CSF) model proposed by Brackbill et al [ 25 ] was adopted to address surface tension at the interface of the gas and liquid. Additional details of the computational methods, and the relative validation and calculation procedures used in the design simulations can be found in Su et al [ 20 ].…”

Section: Design Analysis Methodologymentioning

confidence: 99%

“…The present manuscript is a summary of the previous research investigations by the authors. In previous publication, the device concept (nozzle/diffuser/nozzle) was demonstrated through simulations for each aspect of its functionality, fluid pumping [ 19 ], drug delivery [ 20 , 21 ], or particle sorting [ 22 ] applications. Once we demonstrated the feasibility of each of the applications, we felt that the device concept could be adapted to multiple applications, and that is the focus of the present paper.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Bio-Inspired Multi-Functional Drug Transport Design Concept and Simulations

Pidaparti

Cartin

2017

Bioengineering

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In this study, we developed a microdevice concept for drug/fluidic transport taking an inspiration from supramolecular motor found in biological cells. Specifically, idealized multi-functional design geometry (nozzle/diffuser/nozzle) was developed for (i) fluidic/particle transport; (ii) particle separation; and (iii) droplet generation. Several design simulations were conducted to demonstrate the working principles of the multi-functional device. The design simulations illustrate that the proposed design concept is feasible for multi-functionality. However, further experimentation and optimization studies are needed to fully evaluate the multifunctional device concept for multiple applications.

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Section: Resultsmentioning

confidence: 99%

Section: Design Analysis Methodologymentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Bio-Inspired Multi-Functional Drug Transport Design Concept and Simulations

Pidaparti

Cartin

2017

Bioengineering

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“…Dropletbased microfluidic devices have played important roles in the formation of various functional droplets in a highthroughput and high precision way [3]. A number of so-called "emulsification" techniques including T-junction shearing [4][5][6][7], flow focus necking [8,9], and pneumatic pumping [10] have been reported to generate droplets in a continuous manner.…”

Section: Introductionmentioning

confidence: 99%

3‐Dimensional Microorifice Fabricated Utilizing Single Undercut Etching Process for Producing Ultrasmall Water and Chitosan Droplets

Lin

Lan

Yang

2013

Journal of Nanomaterials

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This research reports a microfluidic device for producing small droplets via a microorifice and a T-junction structure. The orifice is fabricated using an isotropic undercut etching process of amorphous glass materials. Since the equivalent hydraulic diameter of the produced microorifice can be as small as 1.1 m, the microdevice can easily produce droplets of the size smaller than 10 m in diameter. In addition, a permanent hydrophobic coating technique is also applied to modify the main channel to be hydrophobic to enhance the formation of water-based droplets. Experimental results show that the developed microfluidic chip with the ultrasmall orifice can steadily produce water-in-oil droplets with different sizes. Uniform water-in-oil droplets with the size from 60 m to 6.5 m in diameter can be formed by adjusting the flow rate ratio of the continuous phase and the disperse phases from 1 to 7. Moreover, curable linear polymer of chitosan droplets with the size smaller than 100 m can also be successfully produced using the developed microchip device. The microfluidic T-junction with a micro-orifice developed in the present study provides a simple yet efficient way to produce various droplets of different sizes.

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“…1932-1058/2012/6(1)/014118/16/$30.00 V C 2012 American Institute of Physics 6, 014118-1 microfluidic applications by utilizing piezoelectric, [11][12][13][14] electrostatic, 15 pneumatic, 16,17 or magnetic effects. 18 Although these on-chip pumps increase the device portability, integrating the pumping components (e.g., diaphragms, actuators, valves, and heaters) on the device significantly increases the fabrication complexity and device cost.…”

Section: Introductionmentioning

confidence: 99%

A “place n play” modular pump for portable microfluidic applications

Li¹,

Luo²,

Chen³

et al. 2012

Biomicrofluidics

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This paper presents an easy-to-use, power-free, and modular pump for portable microfluidic applications. The pump module is a degassed particle desorption polydimethylsiloxane (PDMS) slab with an integrated mesh-shaped chamber, which can be attached on the outlet port of microfluidic device to absorb the air in the microfluidic system and then to create a negative pressure for driving fluid. Different from the existing monolithic degassed PDMS pumps that are generally restricted to limited pumping capacity and are only compatible with PDMS-based microfluidic devices, this pump can offer various possible configures of pumping power by varying the geometries of the pump or by combining different pump modules and can also be employed in any material microfluidic devices. The key advantage of this pump is that its operation only requires the user to place the degassed PDMS slab on the outlet ports of microfluidic devices. To help design pumps with a suitable pumping performance, the effect of pump module geometry on its pumping capacity is also investigated. The results indicate that the performance of the degassed PDMS pump is strongly dependent on the surface area of the pump chamber, the exposure area and the volume of the PDMS pump slab. In addition, the initial volume of air in the closed microfluidic system and the cross-linking degree of PDMS also affect the performance of the degassed PDMS pump. Finally, we demonstrated the utility of this modular pumping method by applying it to a glass-based microfluidic device and a PDMS-based protein crystallization microfluidic device. V C 2012 American Institute of Physics. [http://dx

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A novel micropump droplet generator for aerosol drug delivery: Design simulations

Cited by 22 publications

References 45 publications

Bio-Inspired Multi-Functional Drug Transport Design Concept and Simulations

Bio-Inspired Multi-Functional Drug Transport Design Concept and Simulations

3‐Dimensional Microorifice Fabricated Utilizing Single Undercut Etching Process for Producing Ultrasmall Water and Chitosan Droplets

A “place n play” modular pump for portable microfluidic applications

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