A novel method for visualising and quantifying through-plane skin layer deformations

Gerhardt, LC Lutz-Christian; Schmidt, J.; Sanz-Herrera, José A.; Baaijens, Fpt Frank; Ansari, Tahera; Peters, Gwm Gerrit; Oomens, Cwj Cees

doi:10.1016/j.jmbbm.2012.05.014

Cited by 47 publications

(25 citation statements)

References 45 publications

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“…the dermis is softer than the epidermis. These results are similar to the findings of Gerhardt et al (2012). The resulting, manually fine-tuned, values for the heterogeneity of k i 2,0 as mentioned in Eq.…”

Section: Digital Image Correlationsupporting

confidence: 85%

“…With a resolution of 3.5-4.3 μm/pixel a field of view (FOV) between 2.3 and 2.8 mm in width and 1.7-2.1 mm in height was produced. Gerhardt et al (2012) proved that the dimensions of the skin sample captured with the current FOV are sufficient to represent the deformation of the total skin sample. These movies were converted into an image sequence using FIJI software (ImageJ, La Jolla, USA).…”

Section: Digital Image Correlationmentioning

confidence: 89%

“…Experimentally, Gerhardt et al (2012) and later (Lamers et al, 2013) studied the response of ex vivo human skin using large amplitude oscillatory shear (LAOS) showing highly nonlinear viscoelastic behavior for shear strains up to 0.1. Additionally, complex mechanical phenomena such as intra-cycle strain stiffening and inter-cycle shear thinning were observed.…”

Section: Introductionmentioning

confidence: 99%

“…With this study we present an improved experimental method, based on the previous work of Gerhardt et al (2012) and Lamers et al (2013), capable of measuring the nonlinear viscoelastic mechanical response of full-thickness human skin to LAOS for strains up to 0.2. This was combined with DIC to assess tissue heterogeneity.…”

Section: Introductionmentioning

confidence: 99%

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A model of human skin under large amplitude oscillatory shear

Soetens

Vijven

Bader

et al. 2018

Journal of the Mechanical Behavior of Biomedical Materials

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A B S T R A C TSkin mechanics is of importance in various fields of research when accurate predictions of the mechanical response of skin is essential. This study aims to develop a new constitutive model for human skin that is capable of describing the heterogeneous, nonlinear viscoelastic mechanical response of human skin under shear deformation. This complex mechanical response was determined by performing large amplitude oscillatory shear (LAOS) experiments on ex vivo human skin samples. It was combined with digital image correlation (DIC) on the cross-sectional area to assess heterogeneity. The skin is modeled as a one-dimensional layered structure, with every sublayer behaving as a nonlinear viscoelastic material. Heterogeneity is implemented by varying the stiffness with skin depth. Using an iterative parameter estimation method all model parameters were optimized simultaneously. The model accurately captures strain stiffening, shear thinning, softening effect and nonlinear viscous dissipation, as experimentally observed in the mechanical response to LAOS. The heterogeneous properties described by the model were in good agreement with the experimental DIC results. The presented mathematical description forms the basis for a future constitutive model definition that, by implementation in a finite element method, has the capability of describing the full 3D mechanical behavior of human skin.

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Section: Digital Image Correlationsupporting

confidence: 85%

Section: Digital Image Correlationmentioning

confidence: 89%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

A model of human skin under large amplitude oscillatory shear

Soetens

Vijven

Bader

et al. 2018

Journal of the Mechanical Behavior of Biomedical Materials

Self Cite

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show abstract

“…The specific method provides an estimation of material properties and a description of the connection between the epidermis and dermis layer of human skin. The related through-plane layer behavior of full-thickness skin tissue was investigated by Gerhardt et al [5] in shear experiments. Real-time video recording captured skin layer deformations used to perform a displacement, strain, and stiffness analysis as well as the assessment of tissue layer interaction.…”

Section: Introductionmentioning

confidence: 99%

Experimental Characterization and Simulation of Layer Interaction in Facial Soft Tissues

Weickenmeier

Lecomte‐Grosbras

et al. 2014

Biomedical Simulation

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Abstract. Anatomically detailed modeling of soft tissue structures such as the forehead plays an important role in physics based simulations of facial expressions, for surgery planning, and implant design. We present ultrasound measurements of through-layer tissue deformation in different regions of the forehead. These data were used to determine the local dependence of tissue interaction properties in terms of variations in the relative deformation between individual layers. A physically based finite element model of the forehead is developed and simulations are compared with measurements in order to validate local tissue interaction properties. The model is used for simulation of forehead wrinkling during frontalis muscle contraction.

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Mechanical Modeling of Skin

Oomens

Peters

2016

Structure-Based Mechanics of Tissues and Organs

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A novel method for visualising and quantifying through-plane skin layer deformations

Cited by 47 publications

References 45 publications

A model of human skin under large amplitude oscillatory shear

A model of human skin under large amplitude oscillatory shear

Experimental Characterization and Simulation of Layer Interaction in Facial Soft Tissues

Mechanical Modeling of Skin

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