A model of human skin under large amplitude oscillatory shear

Soetens, J.F.J.; Vijven, Marc van; Bader, Dan L.; Peters, Gwm Gerrit; Oomens, C.W.J.

doi:10.1016/j.jmbbm.2018.07.008

Cited by 14 publications

(12 citation statements)

References 48 publications

(74 reference statements)

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“…We have captured this heterogeneity by explicitly modeling the morphology of skin. Other researchers have instead focused on the whole-skin ( 43 ) response to load, potentially allowing much larger anatomical regions to be modeled at the expense of microstructure. In the future, computational models of skin should be extended to real-world loading scenarios using multiscale models to account for microstructure.…”

Section: Discussionmentioning

confidence: 99%

Morphology and composition play distinct and complementary roles in the tolerance of plantar skin to mechanical load

et al. 2019

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Plantar skin on the soles of the feet has a distinct morphology and composition that is thought to enhance its tolerance to mechanical loads, although the individual contributions of morphology and composition have never been quantified. Here, we combine multiscale mechanical testing and computational models of load bearing to quantify the mechanical environment of both plantar and nonplantar skin under load. We find that morphology and composition play distinct and complementary roles in plantar skin’s load tolerance. More specifically, the thick stratum corneum provides protection from stress-based injuries such as skin tears and blisters, while epidermal and dermal compositions provide protection from deformation-based injuries such as pressure ulcers. This work provides insights into the roles of skin morphology and composition more generally and will inform the design of engineered skin substitutes as well as the etiology of skin injury.

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Section: Discussionmentioning

confidence: 99%

Morphology and composition play distinct and complementary roles in the tolerance of plantar skin to mechanical load

et al. 2019

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“…Oomens et al [49] suggests that ground substance is the main load-bearing constituent of soft tissues when subjected to compression. For a more complete description of skin mechanical behaviour and associated constitutive theories , the reader is referred to recent published works [17,[50][51][52].…”

Section: Accepted Manuscriptmentioning

confidence: 99%

Biotribology of the ageing skin—Why we should care

et al. 2019

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Ageing of populations has emerged as one of the most pressing societal, economic and healthcare challenges currently facing most nations across the globe. The ageing process itself results in degradation of physiological functions and biophysical properties of organs and tissues, and more particularly those of the skin. Moreover, in both developed and emerging economies, population ageing parallels concerning increases in lifestyleassociated conditions such as Type 2 diabetes, obesity and skin cancers. When considered together, these demographic trends call for even greater urgency to find clinical and engineering solutions for the numerous age-related deficits in skin function. From a tribological perspective, detrimental alterations of skin bioph ysical properties with age have fundamental consequences on how one interacts with the body's inner and outer environments. This stems from the fact that, besides being the largest organ of the human body, and also nearly covering its entirety, the skin is a multifunctional interface which mediates these interactions. The aim of this paper is to present a focused review to discuss some of the consequences of skin ageing from the viewpoint of biotribology, and their implications on health, well -being and human activities. Current and future research questions/challenges associated with biotribology of the ageing ski n are outlined. They provide the background and motivation for identifying future lines of research that could be taken up by the biotribology and biophysics communities.

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“…In order to characterize the mechanical properties of skin in vivo, several methods were proposed such as suction (Müller et al 2018;Diridollou et al 1998Diridollou et al , 2000Barbarino et al 2011), indentation (Virén et al 2018;Abellan et al 2013;Iivarinen et al 2014) and in-situ tension (Flynn et al 2011;Bhushan et al 2010). Uniaxial tension (Wahlsten et al 2019;Ní Annaidh et al 2012), biaxial tension (Tonge et al 2013) and shear experiments (Soetens et al 2018;Lamers et al 2013;Geerligs et al 2011) were performed to determine mechanical properties of skin ex vivo. All data show a pronounced J-shaped stress-strain response, typical for biological tissues.…”

Section: Introductionmentioning

confidence: 99%

A biphasic multilayer computational model of human skin

Sachs

Wahlsten

Kozerke

et al. 2021

Biomech Model Mechanobiol

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The present study investigates the layer-specific mechanical behavior of human skin. Motivated by skin’s histology, a biphasic model is proposed which differentiates between epidermis, papillary and reticular dermis, and hypodermis. Inverse analysis of ex vivo tensile and in vivo suction experiments yields mechanical parameters for each layer and predicts a stiff reticular dermis and successively softer papillary dermis, epidermis and hypodermis. Layer-specific analysis of simulations underlines the dominating role of the reticular dermis in tensile loading. Furthermore, it shows that the observed out-of-plane deflection in ex vivo tensile tests is a direct consequence of the layered structure of skin. In in vivo suction experiments, the softer upper layers strongly influence the mechanical response, whose dissipative part is determined by interstitial fluid redistribution within the tissue. Magnetic resonance imaging-based visualization of skin deformation in suction experiments confirms the deformation pattern predicted by the multilayer model, showing a consistent decrease in dermal thickness for large probe opening diameters.

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A model of human skin under large amplitude oscillatory shear

Cited by 14 publications

References 48 publications

Morphology and composition play distinct and complementary roles in the tolerance of plantar skin to mechanical load

Morphology and composition play distinct and complementary roles in the tolerance of plantar skin to mechanical load

Biotribology of the ageing skin—Why we should care

A biphasic multilayer computational model of human skin

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