A novel method for the synthesis of 4(3H)-quinazolinones

A novel catalyst zinc(II) perfluorooctanoate [Zn(PFO)2]-catalyzed three-component one-pot reaction: Synthesis of quinazolinone derivatives in aqueous micellar media

“…Some possible mechanisms of this three-component one-pot reaction had been reported before by and Abdel-Jalil et al [30]. By tracing the reaction by the TLC, we have found a new product on the TLC within a few minutes, which would be an important intermediate of the reaction.…”

Zn[(L)-proline] as a Recyclable and Green Catalyst for Efficient and One-pot Three-Component Synthesis of 1,4-Dihydro- pyridines Under Solvent-Free and Microwave Irradiation Conditions

“…Other synthetic methods includes treatment of phosphoranes with NaH/CH 3 CN 20 , pyrolysis of Schiff bases derived from 3-amino-1,2,3-triazineone in paraffin oil at 300 0 C 21 . The most general method for synthesis of these compounds involves cyclocondensation of anthranilamides with aldehydes in the presence of various promoting agents, such as p-toluenesulfonic acid/DDQ 22 , I 2 /KI in water 23 , CuCl 2 in ethanol 24 , DDQ/DMF 25 , Sc(oTf) 3 26 , NaHSO 3 27 , SnCl 4 In continuation of our interest in finding environmentally benign method for the synthesis of various heterocyclic compounds [37][38][39][40][41][42] , here in we want to report for first time, a new and efficient synthesis of 4(3H)-quinazolinones in the presence ofZn[(L)-proline] 2 as a lewis acid catalyst under solvent-free conditions (Scheme 1).…”

An efficient synthesis of 3-benzylquinazolin-4(1H)-one derivatives under catalyst-free and solvent-free conditions

“…Several years ago, Shi reported one-pot synthesis of quinazolin derivatives using TiCl 4 -Zn as catalyst in anhydrous THF (10). Some other methods for the synthesis of quinazolin derivatives involved the condensation of 2-aminobenzamide with aldehydes or ketones in the presence of multiple catalysts such as CuCl 2 (11), NH 4 Cl (12), Sc(OTf) 3 (13), SmI 2 (14), Zn(PFO) 2 (15) and so on. Most of the reported methods often suffer from tedious procedures and low yields.…”