An efficient synthesis of 3-benzylquinazolin-4(1<i>H</i>)-one derivatives under catalyst-free and solvent-free conditions

Wang, Suhui; Yin, Shou-Wei; Sheng, Xia; Shi, Yanhui; Tu, Shu‐Jiang; Rong, Liangce

doi:10.1080/17518253.2012.685184

Cited by 6 publications

(1 citation statement)

References 29 publications

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“…Hence, development of new synthetic methodologies under solvent-free conditions is an important area of research with growing popularity. The interest for solvent-free reactions arises from advantages such as reducing or eliminating solvent usage and consequently low pollution and costs, simplicity in relevant processes, and handling (1)(2)(3)(4). These factors are especially important in industry.…”

Section: Introductionmentioning

confidence: 99%

Organocatalytic clean synthesis of densely functionalized 4H-pyrans by bifunctional tetraethylammonium 2-(carbamoyl)benzoate using ball milling technique under mild conditions

Dekamin

Alikhani

Javanshir

2016

Green Chemistry Letters and Reviews

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A green and simple method has been developed for efficient preparation of diverse annulated 2-amino-3-cyano-4H-pyran derivatives in the presence of a low loading of tetraethylammonium 2-(carbamoyl)benzoate (TEACB), as a bifunctional organocatalyst, under solvent-free conditions using the ball milling technique. This procedure is a clean, transition-metal-free, and environmentally friendly approach that offers many advantages including short reaction times, high to quantitative yields, low cost, and straightforward work-up. ARTICLE HISTORY

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Section: Introductionmentioning

confidence: 99%

Organocatalytic clean synthesis of densely functionalized 4H-pyrans by bifunctional tetraethylammonium 2-(carbamoyl)benzoate using ball milling technique under mild conditions

Dekamin

Alikhani

Javanshir

2016

Green Chemistry Letters and Reviews

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An Efficient and Facile Multicomponent Reaction for the Synthesis of 5′,6′‐dihydro‐6′‐hydroxy‐6′‐(trifluoromethyl)‐1′H‐spiro[indoline‐3,4′‐pyrimidine]‐2,2′(3′H)‐dione Derivatives under Solvent‐Free Conditions

Yan

Qin

et al. 2017

Journal of Heterocyclic Chem

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The reactions of isatins, urea, and different diketones under solvent‐free conditions have been developed for the preparation of novel spiroheterocycles. It was found that these reactions could be given higher yields and required shorter time compared with commonly used volatile organic solvent conditions. In this synthesis, the important group trifluoromethyl was introduced into the structure of the products. The pure products could be obtained only through removing TsOH, isatins, and urea from hot water. At same time, diketone was eliminated through a small amount of EtOH. Other advantages of this method are simple setup, mild conditions, and minimal environment impact.

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Synthesis of antioxidant and antibacterial active quinazolinones by carboxymethyl cellulose@MnFe2O4 biocatalyst

Rahimi,

Nezhad,

Zare

et al. 2023

Inorganic Chemistry Communications

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An efficient synthesis of 3-benzylquinazolin-4(1H)-one derivatives under catalyst-free and solvent-free conditions

Cited by 6 publications

References 29 publications

Organocatalytic clean synthesis of densely functionalized 4H-pyrans by bifunctional tetraethylammonium 2-(carbamoyl)benzoate using ball milling technique under mild conditions

Organocatalytic clean synthesis of densely functionalized 4H-pyrans by bifunctional tetraethylammonium 2-(carbamoyl)benzoate using ball milling technique under mild conditions

An Efficient and Facile Multicomponent Reaction for the Synthesis of 5′,6′‐dihydro‐6′‐hydroxy‐6′‐(trifluoromethyl)‐1′H‐spiro[indoline‐3,4′‐pyrimidine]‐2,2′(3′H)‐dione Derivatives under Solvent‐Free Conditions

Synthesis of antioxidant and antibacterial active quinazolinones by carboxymethyl cellulose@MnFe2O4 biocatalyst

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