A novel lymphatic pattern promotes metastasis of cervical cancer in a hypoxic tumour-associated macrophage-dependent manner

Chen, Xiaojing; Wei, W.; Wang, Zi-Ci; Wang, Nisha; Guo, Chu-Hong; Zhou, Chenfei; Liang, Luo-Jiao; Wu, Sha; Li, Liang; Wang, Wei

doi:10.1007/s10456-020-09766-2

Cited by 29 publications

(28 citation statements)

References 55 publications

(64 reference statements)

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“…Recent evidence has indicted that IL‐6 secreted by tumour‐associated macrophages enhances metastatic colonisation of CRC cells (Toyoshima et al., 2019; Zhong et al., 2020). Similarly, CCL1 and CCL2 have been shown to promote tumour metastasis by facilitating tumour‐associated macrophage recruitment (Chen et al., 2018, 2021). These data support our findings that CRC‐EV‐activated macrophages release IL‐6, CCL1 and CCL2 to potentiate CRC cell migration.…”

Section: Discussionmentioning

confidence: 99%

Extracellular vesicles from colorectal cancer cells promote metastasis via the NOD1 signalling pathway

Wei

Pei

et al. 2022

J of Extracellular Vesicle

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Pattern-recognition receptors (PRRs) have been shown to promote tumour metastasis via sensing tumour cell-derived small extracellular vesicles (EVs). Nucleotidebinding oligomerisation domain 1 (NOD1), a cytoplasmic PRR, plays a role in colorectal cancer (CRC) by detecting bacterial products. However, the precise mechanisms underlying the effects of NOD1, following identification of CRC cell-derived EVs (CRC-EVs), to potentiate CRC liver metastasis (CRC-LM), remain poorly understood. Here, we demonstrate that CRC-EVs activate NOD1 in macrophages to initiate secretion of inflammatory cytokines and chemokines. NOD1-activated macrophages also promote CRC cell migration, while in a murine model of liver metastasis (LM), NOD1-deficient mice exhibit reduced metastasis following CRC-EV treatment. Furthermore, cell division cycle 42 (CDC42), a small Rho guanosine-5′-triphosphate (GTP)ase, is delivered by CRC-EVs into macrophages where it activates NOD1. In addition, EVs from the plasma of patients with CRC-LM mediate NOD1 activation in human peripheral blood mononuclear cells. Moreover, high NOD1 expression in tumour tissues is associated with poor prognosis of CRC-LM. Our findings suggest that CRC-EVs activate NOD1 to promote tumour metastasis, thus, NOD1 may serve as a potential target in the diagnosis and treatment of CRC-LM.

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Section: Discussionmentioning

confidence: 99%

Extracellular vesicles from colorectal cancer cells promote metastasis via the NOD1 signalling pathway

Wei

Pei

et al. 2022

J of Extracellular Vesicle

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“…In GO enrichment analysis, cell division-related biological processes such as nucleosome assembly, nucleosome organization, chromatin assembly, or disassembly were found to be deeply involved in the initial lymphatic metastasis of COAD. This might be due to increased cancer cell division and the proliferation of new lymphatic vessels [ 40 , 41 ]. KEGG enrichment analysis revealed that systemic lupus erythematosus was the most significantly enriched pathway, and furthermore, the single GSEA validated this result, suggesting that the systemic lupus erythematosus pathway may be crucial for initial lymphatic metastasis in COAD.…”

Section: Discussionmentioning

confidence: 99%

Six Genes Associated with Lymphatic Metastasis in Colon Adenocarcinoma Linked to Prognostic Value and Tumor Immune Cell Infiltration

Wang

Yin

Yang

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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Objective. The aim of the study is to explore the relationship between lymphatic metastasis genes, prognosis, and immune cell infiltration in patients with colon cancer. Methods. Based on the Cancer Genome Atlas Program (TCGA) database, differentially expressed genes and prognostic genes related to colon adenocarcinoma (COAD) lymphatic metastasis were screened and intersected. We used lasso and univariate Cox regression analysis to screen core genes and establish a preliminary prediction model. GO and KEGG enrichment analysis was used for lymphatic metastasis-related genes, and single GSEA was used for the final screening results. Finally, we evaluated the relationship between identified genes and immune cell infiltration. Results. A total of 1727 genes were differentially expressed between COAD patients with TNM stages of N0 and N1. After further screening, six core genes (RNU4-2, ZNF556, RNVU1-15, NSA2P6, RN7SL767P, and RN7SL473P) were obtained, and a preliminary prediction model was established, in which ZNF556 was a risk factor, and the rest were protective factors. Single GSEA showed that pathways such as systemic lupus erythematosus might play an important role in the initial lymphatic metastasis of COAD. GO and KEGG enrichment analysis of 1727 genes supported this result. Immune infiltration analysis showed that six genes were significantly correlated with T cell and NK cell families. Conclusion. Six core genes may affect COAD initial lymphatic metastasis through the systemic lupus erythematosus pathway and immune cell infiltration.

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“…IHC staining of human cervical squamous cell carcinoma tissue demonstrated that, under hypoxic conditions, lymphatic vessels were encapsulated by CD163 + TAMs, and the LVD was higher compared with that under normoxic conditions (108). These structures were referred to as lymphatic vessels encapsulated by TAMs (LVEM) (108). Hypoxic TAMs exhibited high IL-10 expression (108).…”

Section: Tams Induce Lymphangiogenesismentioning

confidence: 99%

Interaction of tumor‑associated macrophages with stromal and immune components in solid tumors: Research progress (Review)

et al. 2023

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Tumor-associated macrophages (TAMs) are crucial cells of the tumor microenvironment (TME), which belong to the innate immune system and regulate primary tumor growth, immunosuppression, angiogenesis, extracellular matrix remodeling and metastasis. The review discusses current knowledge of essential cell-cell interactions of TAMs within the TME of solid tumors. It summarizes the mechanisms of stromal cell (including cancer-associated fibroblasts and endothelial cells)-mediated monocyte recruitment and regulation of differentiation, as well as pro-tumor and antitumor polarization of TAMs. Additionally, it focuses on the perivascular TAM subpopulations that regulate angiogenesis and lymphangiogenesis. It describes the possible mechanisms of reciprocal interactions of TAMs with other immune cells responsible for immunosuppression. Finally, it highlights the perspectives for novel therapeutic approaches to use combined cellular targets that include TAMs and other stromal and immune cells in the TME. The collected data demonstrated the importance of understanding cell-cell interactions in the TME to prevent distant metastasis and reduce the risk of tumor recurrence.

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A novel lymphatic pattern promotes metastasis of cervical cancer in a hypoxic tumour-associated macrophage-dependent manner

Cited by 29 publications

References 55 publications

Extracellular vesicles from colorectal cancer cells promote metastasis via the NOD1 signalling pathway

Extracellular vesicles from colorectal cancer cells promote metastasis via the NOD1 signalling pathway

Six Genes Associated with Lymphatic Metastasis in Colon Adenocarcinoma Linked to Prognostic Value and Tumor Immune Cell Infiltration

Interaction of tumor‑associated macrophages with stromal and immune components in solid tumors: Research progress (Review)

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