A novel liquid chromatography-tandem mass spectrometry method for determination of menadione in human plasma after derivatization with 3-mercaptopropionic acid

Liu, Ruijuan; Wang, Mengmeng; Ding, Li

doi:10.1016/j.talanta.2014.04.039

Cited by 8 publications

(11 citation statements)

References 35 publications

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“…Protein precipitation (PP), liquid-liquid extraction (LLE), and solid-phase extraction (SPE) are the three most common techniques used for vitamin K purification process in biological matrix to achieve efficient analyte recovery by reducing ion suppression and enhancement of analyte signal. Other approaches such as performing derivatization reactions (25)(26)(27)(28), emulsification mircroextraction (29), and sonication (30) have also been reported in sample preparations. PP is a rapid, generic and relative inexpensive sample preparation method.…”

Section: Sample Pretreatment Methodsmentioning

confidence: 99%

“…Stripped matrices approach has also been taken in important consideration for vitamin K quantitation (54,65). Liu & coworkers used UV light to prepare stripped plasma matrix for menadione quantitation in human plasma through LC-MS approach (27). Klapkova et al also used UV light stripped method for determination of vitamin K and its analogues in postmenopausal women's serum by HPLC-FD detection (9).…”

Section: Calibration Approaches For Quantitation Of Vitamin Kmentioning

confidence: 99%

“…Liu et al quantified menadione by a novel LC-MS/MS method after derivatization with 3-mercaptopropionic acid and found 33-fold better lower limit of quantification than the underivatized compound. This highly sensitive method could be applied to future research on menadione and its prodrug (27). A method utilizing sample freezing and lipid precipitation was developed by Gentili & group while determining VK 1 , MK-4 and VK 1 O concentrations by HPLC-MS/MS.…”

Section: Human Serum Plasma and Bloodmentioning

confidence: 99%

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A concise review of quantification methods for determination of vitamin K in various biological matrices

Zhang

Bala

Mao

et al. 2019

Journal of Pharmaceutical and Biomedical Analysis

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Vitamin K is an essential nutrient in the body and involved in numerous physiological and pathophysiological functions. Both the lack and surplus of vitamin K can put human health at risk. Therefore, it becomes necessary to monitor vitamin K concentrations in different biomatrices through establishing sensitive and specific analytical methods. This review collectively describes an updated overview of the sample pretreatment methodologies and methods for quantitative determination of vitamin K that have been used in last two decades. High Performance Liquid Chromatography (HPLC) is commonly utilized as a standard for separation of vitamin K in combination with different detection including spectroscopic, spectrometric, fluorometric and mass spectroscopy. Recent progress in sample pretreatment technologies and quantitation methodologies have enhanced the ability to identify and quantitate vitamin K in biomatrices to further advance our understanding of the role of this vitamin in human health and disease.

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Section: Sample Pretreatment Methodsmentioning

confidence: 99%

Section: Calibration Approaches For Quantitation Of Vitamin Kmentioning

confidence: 99%

Section: Human Serum Plasma and Bloodmentioning

confidence: 99%

See 1 more Smart Citation

A concise review of quantification methods for determination of vitamin K in various biological matrices

Zhang

Bala

Mao

et al. 2019

Journal of Pharmaceutical and Biomedical Analysis

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“…Both contain a 2-methyl-1,4-naphthoquinone ring in their structure and differ as regard the substituent at the 3-position, which is a phytyl chain for PK and a side chain with repeated isoprenoid units for MK. Whereas PK appears in nature as a single compound, MK comprises a series of vitamers containing from 3 to 14 isoprene units (MK-3 to MK-14). , PK and MK are the natural forms of vitamin K, whereas menadione (MD, vitamin K 3 ) is a synthetic derivative used as a pharmaceutical, although the cleavage of dietary PK to produce MD by intestinal bacteria has been described …”

Section: Introductionmentioning

confidence: 99%

Microwave Assisted Cloud Point Extraction for the Determination of Vitamin K Homologues in Vegetables by Liquid Chromatography with Tandem Mass Spectrometry

Campillo

Marín

Viñas

et al. 2019

J. Agric. Food Chem.

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Liquid chromatography-electrospray ionization tandem mass spectrometry (LC-ESI-MS/MS) with a triple quadrupole (QqQ) is proposed for determining the vitamin K homologues, phylloquinone (PK), menaquinone-4 (MK) and menadione (MD), in vegetables. The analytes were isolated from the samples (1−1.5 g) by ultrasound assisted extraction using acetonitrile (2 mL), and the liquids were submitted to microwave assisted cloud point extraction with Triton X-45. The enrichment factors were between 20 and 50, depending on the vitamin homologue in question. The analytes were determined by LC-ESI-QqQ-MS/MS in the multiple reaction monitoring (MRM) mode, providing unequivocal identification and quantification, with limits of detection of 0.8, 1.0, and 16 ng/g for MK, PK, and MD, respectively. Recovery assays for samples spiked at two concentration levels, between 40 and 600 ng/g depending on the compound, provided recoveries in the 90−114% range. Only PK was detected in the samples analyzed, at concentrations in the 90−2350 ng/g range.

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“…Successful determination of MD based on LC-MS/MS can be performed by quantifying the levels of MK-4 generated in the enzymatic reaction of recombinant human UBIAD1 with deuterium-labeled geranylgeranyl pyrophosphate (GGPP). 2 Moreover, Liu et al 9 recently reported an LC-MS/MS method for determination of MD relying on derivatization with 3-mercaptopropionic acid via Michael addition. The above methods for determination of MD are effective but complicated, necessitating the development of a novel facile analytical procedure.…”

Section: Introductionmentioning

confidence: 99%

Determination of Menadione by Liquid Chromatography-Tandem Mass Spectrometry Using Pseudo Multiple Reaction Monitoring

et al. 2017

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This study aimed to develop a menadione (MD) determination method employing liquid chromatography-tandem mass spectrometry (LC-MS/MS) using a pseudo multiple reaction monitoring (MRM) technique, wherein two quadrupoles are used to monitor the same ion. Detection limits of 40 and 2 pg were obtained for MD and its deuterium-labeled form, respectively, whereas MD intra-and inter-assay coefficient of variation values were determined as 5.4 -8.2%, with the corresponding recoveries equaling 90.5 -109.6%. The developed method enables determination of MD in urine, plasma, cell extract, and culture media, demonstrating that pseudo multiple reaction monitoring can achieve quantification of compounds forming no suitable product ions, such as MD.

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A novel liquid chromatography-tandem mass spectrometry method for determination of menadione in human plasma after derivatization with 3-mercaptopropionic acid

Cited by 8 publications

References 35 publications

A concise review of quantification methods for determination of vitamin K in various biological matrices

A concise review of quantification methods for determination of vitamin K in various biological matrices

Microwave Assisted Cloud Point Extraction for the Determination of Vitamin K Homologues in Vegetables by Liquid Chromatography with Tandem Mass Spectrometry

Determination of Menadione by Liquid Chromatography-Tandem Mass Spectrometry Using Pseudo Multiple Reaction Monitoring

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