A novel in-plane passive microfluidic mixer with modified Tesla structures

Hong, Chien-Chong; Choi, Jin‐Woo; Ahn, Chong H.

doi:10.1039/b305892a

Cited by 386 publications

(285 citation statements)

References 19 publications

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“…Several novel approaches that have been utilized in microfluidic actuators/valves include hydraulically-actuated valves [11]; phase change valves operating with paraffin [12] and ice [13,14]; passive valves that take advantage of variations in surfaces' wetting properties [15]; check valves [16]; and viscosity-controlled valves. The latter types of valves operate with specialized fluids that change their viscosity in response to external stimuli such as temperatureresponsive pluronic solution [17] and a ferrofluid that responds to magnetic-field variations [18].…”

Section: Introductionmentioning

confidence: 99%

Self-Actuated, Thermo-Responsive Hydrogel Valves for Lab on a Chip

Wang

Chen

Mauk

et al. 2005

Biomed Microdevices

146

108

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An easy to fabricate, thermally-actuated, self-regulated hydrogel valve for flow control in pneumatically driven, microfluidic systems is described. This microvalve takes advantage of the properties of the hydrogel, poly(Nisopropylacrylamide), as well as the aqueous fluid itself to realize flow control. The valve was designed for use in a diagnostic system fabricated with polycarbonate and aimed at the detection of pathogens in oral fluids at the location of the sample collection. The paper describes the construction and characterization of the hydrogel valves and their application for flow control, sample and reagent metering, sample distribution into multiple analysis paths, and the sealing of a polymerase chain reaction (PCR) reactor to suppress bubble formation. The hydrogel-based flow control is electronically addressable, does not require any moving parts, introduces minimal dead volume, is leakage and contaminant free, and is biocompatible. KeywordsMicrovalve, microfluidics, hydrogel, lab-on-a-chip, metering, distribution, PCR Wang, J., Chen, Z., Mauk, M., Hong, K-S, Li, M., Yang, S., and Bau, H., H Wang, J., Chen, Z., Mauk, M., Hong, K-S, Li, M., Yang, S., and Bau, H., H., 2005, Self-Actuated, ThermoResponsive Hydrogel Valves for Lab on a Chip, Biomedical Microdevices 7 (4), 313-322.., 2005, Self-Actuated, Thermo-Responsive Hydrogel Valves for Lab on a Chip, Biomedical Microdevices 7 (4), 313-322. ABSTRACTAn easy to fabricate, thermally-actuated, self-regulated hydrogel valve for flow control in pneumatically driven, microfluidic systems is described. This microvalve takes advantage of the properties of the hydrogel, poly(N-isopropylacrylamide), as well as the aqueous fluid itself to realize flow control. The valve was designed for use in a diagnostic system fabricated with polycarbonate and aimed at the detection of pathogens in oral fluids at the location of the sample collection. The paper describes the construction and characterization of the hydrogel valves and their application for flow control, sample and reagent metering, sample distribution into multiple analysis paths, and the sealing of a polymerase chain reaction (PCR) reactor to suppress bubble formation. The hydrogel-based flow control is electronically addressable, does not require any moving parts, introduces minimal dead volume, is leakage and contaminant free, and is biocompatible.

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Section: Introductionmentioning

confidence: 99%

Self-Actuated, Thermo-Responsive Hydrogel Valves for Lab on a Chip

Wang

Chen

Mauk

et al. 2005

Biomed Microdevices

146

108

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“…Then they were mixed with the other sub-stream, producing a strong impact around the sub-channel of the micromixer by exploiting the Coanda effect [12]. The splitting and recombining of the flow effectively reduce the diffusion path between the fluid streams by producing transverse Taylor dispersion, which enhances the convective mixing of the two fluids [12]. The performance of the mixer is tested with flows of 1 μL/min to 100 μL/min; it gave an excellent mixing level of 44% concentration and a reasonable agreement was found between the experiments and the CFD results.…”

Section: Introductionmentioning

confidence: 99%

Passive Micromixers with Interlocking Semi-Circle and Omega-Shaped Modules: Experiments and Simulations

et al. 2015

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This study presents experiments and computational simulations of single-layer passive micromixer designs. The proposed designs consist of chains of interlocking semicircles and omega-shaped mixing modules. The performance of the new designs is compared with the concentric spiral channel configuration. The micromixers are intended to be integrated into a lab on chip (LOC) micro-system that operates under continuous flow conditions. The purpose behind the multi-curvature in these designs is the introduction of Dean vortices in addition to molecular diffusion in order to enhance the mixing performance. The micromixers were fabricated in PDMS (Polydimethylsiloxane) and bonded to a glass substrate. A three-dimensional computational model of micromixers was carried out using Fluent ANSYS. In experiments, the mixing of a 1 g/L fluorescein isothiocyanate diluted in distilled water was observed and photographed using a charge-coupled device (CCD) microscopic camera. The obtained images were processed to determine the mixing intensity at different Reynolds numbers. The standard deviation (σ) of the fluorescence indicates the mixing completeness, which was calculated along the width of the channel at various locations downstream from the channel inlet. The value of σ = 0.5 indicates unmixed streams and 0 is for complete mixing. It is found that the two new designs have a standard deviation of nearly 0.05. Additionally, complete mixing was observed at the channel outlet as demonstrated by OPEN ACCESSMicromachines 2015, 6 954 the fluorescence images and the numerical results. However, the location of complete mixing at different positions depends on the Reynolds number, which varies between 0.01 and 50. Good agreement was found between the experiment and the numerical results. A correlation to predict the length scale where complete mixing can be achieved is given in terms of the radius of curvature, the mixing module, and the Reynolds number.

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“…In this regard, mathematical modeling plays an important role in the study of these flows. Computational fluid dynamics has been extensively used to investigate the design of micromixers (see, e.g., reviews [2,4] and papers [5][6][7][8][9][10][11], as well as the references therein).…”

Section: Introductionmentioning

confidence: 99%

Modeling and Optimization of Y-Type Micromixers

Rudyak

Минаков

2014

Micromachines

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A trend in the global technological progress in the last few decades is the development of microsystem technology, microelectromechanical systems and corresponding technologies. Fluid mixing is an extremely important process widely used in various microfluidic devices (chemical microreactors, chemical and biological analyzers, drug delivery systems, etc.). To increase the mixing rate, it is necessary to use special devices: micromixers. This paper presents the results of a hydrodynamic simulation of Y-shaped micromixers. Flows are analyzed for both low and moderate Reynolds numbers. The passive and active mixers are considered. The dependence of the mixing efficiency on the Reynolds and Péclet numbers, as well as the possibility of using the hydrophobic and ultra-hydrophobic coatings is analyzed. Five different flow regimes were identified: (1) stationary vortex-free flow (Re < 5); (2) stationary symmetric vortex flow with two horseshoe vortices (5 < Re < 150); (3) stationary asymmetric vortex flow (150 < Re < 240); (4) non-stationary periodic flow (240 < Re < 400); and (5) stochastic flow (Re > 400). The maximum mixing efficiency was obtained for stationary asymmetric vortex flow.

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A novel in-plane passive microfluidic mixer with modified Tesla structures

Cited by 386 publications

References 19 publications

Self-Actuated, Thermo-Responsive Hydrogel Valves for Lab on a Chip

Self-Actuated, Thermo-Responsive Hydrogel Valves for Lab on a Chip

Passive Micromixers with Interlocking Semi-Circle and Omega-Shaped Modules: Experiments and Simulations

Modeling and Optimization of Y-Type Micromixers

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