A novel IgA-like immunoglobulin in the reptile Eublepharis macularius

Deza, Francisco Gambón; Espinel, Christian Sánchez; Beneitez, Julio Valdueza

doi:10.1016/j.dci.2006.09.005

Cited by 69 publications

(17 citation statements)

References 27 publications

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“…It appears to have evolved from a duplication of the IgM constant region recombined with IgY-like domains. An IgA-like antibody with features similar to both IgY and IgM found in gecko lizards supports this hypothesis of the evolutionary origin of IgA (Gambón-Deza et al, 2007).…”

Section: Gnathostome Immune Cells and Moleculessupporting

confidence: 58%

Comparative Phylogeny of the Mucosa-Associated Lymphoid Tissue

Salinas

Miller

2015

Mucosal Immunology

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Section: Gnathostome Immune Cells and Moleculessupporting

confidence: 58%

Comparative Phylogeny of the Mucosa-Associated Lymphoid Tissue

Salinas

Miller

2015

Mucosal Immunology

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“…Its expression on the surface of B cells has not been described thus far, although mRNA transcript expression levels and distribution are similar to those of IgM (70). An IgA-like antibody was recently found in the intestine of the leopard gecko (71). Authors considered this an IgA-like Ig based on the high transcript levels of this molecule in the intestine (whereas no expression was detected in liver or blood) and on its homology in primary sequence with Xenopus IgX and bird IgA.…”

Section: Reptilian B Cellsmentioning

confidence: 99%

Evolution of B Cell Immunity

Parra

Takizawa

Sunyer

2013

Annu. Rev. Anim. Biosci.

116

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Two types of adaptive immune strategies are known to have evolved in vertebrates: the VLR-based system, which is present in jawless organisms and is mediated by VLRA and VLRB lymphocytes, and the BCR/TCR-based system, which is present in jawed species and is provided by B and T cell receptors expressed on B and T cells, respectively. Here we summarize features of B cells and their predecessors in the different animal phyla, focusing the review on B cells from jawed vertebrates. We point out the critical role of nonclassical species and comparative immunology studies in the understanding of B cell immunity. Because nonclassical models include species relevant to veterinary medicine, basic science research performed in these animals contributes to the knowledge required for the development of more efficacious vaccines against emerging pathogens.

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“…Recently, IgM, IgD and IgY genes have been identified in reptile, the green anole lizard (Anolis carolinensis) with available genome data [9], and also in an economically important species [10]. An IgA-like immunoglobulin has also been identified in leopard gecko (Eublepharis macularius) [11]. Five Ig isotypes, IgM, IgD, IgX, IgY, IgF have been reported from anuran amphibians [12e15], and IgM, IgY and recently IgP identified in urodele amphibians [16].…”

Section: Introductionmentioning

confidence: 99%