Comparative Phylogeny of the Mucosa-Associated Lymphoid Tissue

Salinas, Irene; Miller, Robert D.

doi:10.1016/b978-0-12-415847-4.00010-0

“…The evolution of MALT in vertebrates mirrors the main physiological innovations that vertebrates adopted in their transition from water to land. There is MALT in every anatomical location where a mucosal epithelium is in direct contact with the external environment, thus, some tissues such as the gut, have followed this criterion from lamprey to mammals, including humans (Salinas & Miller, 2015). In all vertebrates, including cetaceans, lymphoid tissues can have two different structures: organized lymphoid tissue, known as O‐MALT, which includes tonsils and Peyer patches, and diffuse lymphoid tissue, or D‐MALT, which is made up of a diffuse network of immune cells, typical of the poikilothermic vertebrates (Asanuma et al, 1997; Lee et al, 2015; Mitchell & Criscitiello, 2020; Sepahi & Salinas, 2016; Tamura et al, 1998).…”

Section: Introductionmentioning

confidence: 99%

Immunohistochemistry of the nasal cavity‐associated lymphoid tissue in the dolphin (Stenella coeruleoalba, Meyen 1833)

Miller,

Lombardo,

Guerrera

et al. 2024

Microscopy Res & Technique

0

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The striped dolphin (Stenella coeruleoalba) is a medium‐sized pelagic dolphin with a single external nasal opening (blowhole) located in the rostral and dorsal regions of the skull. The nasal cavity is divided into three sections: the olfactory, respiratory, and vestibular areas. The surface epithelium lining the regio vestibularis is the first tissue in the nose to be directly affected by environmental antigens. Cetaceans have a significant amount of mucosa‐associated lymphoid tissue (MALT) located throughout their bodies. The lymphoid tissue found in the nasal mucosa is known as nose‐ or nasopharynx‐associated lymphoid tissue (NALT). NALT has not yet been studied in dolphins, but it has been identified and documented in humans and laboratory rodents. This study utilized toll‐like receptor 2 (TLR2), CD4, Langerin/CD207, and inducible nitric oxide synthase to characterize, for the first time, immune cells in the mucosal regio vestibularis of the S. coeruleoalba nasal cavity using confocal microscopy immunofluorescence techniques. The findings revealed scattered immune cells immunoreactive to the tested antibodies, present in both the epithelial tissue lining the nasal cavity vestibulum and the underlying connective tissue. This study enhances our comprehension of the immune system of cetaceans.Research Highlights This study provides new insights into NALT in S. coeruleoalba. This research deepens the knowledge of the skin of cetaceans.

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Anatomy of Teleost Fish Immune Structures and Organs

Bjørgen

¹

,

Koppang

²

2022

Principles of Fish Immunology

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The function of a tissue is determined by its construction and cellular composition. The action of different genes can thus only be understood properly when seen in the context of the environment in which they are expressed and function. We now experience a renaissance in morphological research in fish, not only because, surprisingly enough, large structures have remained un-described until recently, but also because improved methods for studying morphological characteristics in combination with expression analysis are at hand. In this review, we address anatomical features of teleost immune tissues. There are approximately 30,000 known teleost fish species and only a minor portion of them have been studied. We aim our review at the Atlantic salmon (Salmo salar) and other salmonids, but when applicable, we also present information from other species. Our focus is the anatomy of the kidney, thymus, spleen, the interbranchial lymphoid tissue (ILT), the newly discovered salmonid cloacal bursa and the naso-pharynx associated lymphoid tissue (NALT).

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Anatomy of teleost fish immune structures and organs

Bjørgen

¹

,

Koppang

²

2021

View full text Add to dashboard Cite

The function of a tissue is determined by its construction and cellular composition. The action of different genes can thus only be understood properly when seen in the context of the environment in which they are expressed and function. We now experience a renaissance in morphological research in fish, not only because, surprisingly enough, large structures have remained un-described until recently, but also because improved methods for studying morphological characteristics in combination with expression analysis are at hand. In this review, we address anatomical features of teleost immune tissues. There are approximately 30,000 known teleost fish species and only a minor portion of them have been studied. We aim our review at the Atlantic salmon (Salmo salar) and other salmonids, but when applicable, we also present information from other species. Our focus is the anatomy of the kidney, thymus, spleen, the interbranchial lymphoid tissue (ILT), the newly discovered salmonid cloacal bursa and the naso-pharynx associated lymphoid tissue (NALT).

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Comparative Phylogeny of the Mucosa-Associated Lymphoid Tissue

Cited by 7 publications

References 115 publications

Immunohistochemistry of the nasal cavity‐associated lymphoid tissue in the dolphin (Stenella coeruleoalba, Meyen 1833)

Immunohistochemistry of the nasal cavity‐associated lymphoid tissue in the dolphin (Stenella coeruleoalba, Meyen 1833)

Anatomy of Teleost Fish Immune Structures and Organs

Anatomy of teleost fish immune structures and organs

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