A novel HLA‐B*15 allele, HLA‐B*15:326, was identified in a Chinese bone marrow donor

Abstract

HLA-B*15:326 has one base substitution at position 176G>A in exon 2 compared with HLA-B*15:01:01:01.

Identification of the novel HLA‐B*27:147 allele by polymerase chain reaction sequence‐based typing

“…To further confirm the alleles of HLA‐B in the sample, the HLA‐B*15 and HLA‐B*27 alleles were amplified with the allelic specific primer separately as our previous reports . The sequencing results showed HLA‐B alleles of the sample as HLA‐B*15:18 and a novel allele.…”

“…To further confirm the alleles of HLA-B in the sample, the HLA-B*15 and HLA-B*27 alleles were amplified with the allelic specific primer separately as our previous reports. [2][3][4] The sequencing results showed HLA-B alleles of the sample as HLA-B*15:18 and a novel allele. The new allele was identical to HLA-B*27:04 except for 1 base change from Cytosine to Guanine at position nucleotide 523 in exon 3, resulting in an amino acid change from Arginine to Glycine at codon 151 ( Figure 1).…”

Characterization of the novel HLA allele: HLA‐B*15:437 in a Chinese bone marrow donor

“…In order to further confirm the alleles of HLA‐B in the sample, we amplified the HLA‐B*15 and HLA‐B*38 alleles separately using allele specific primers and sequenced both alleles for exons 2 to 4 according to our previous reports 3,4 . The sequencing results showed HLA‐B alleles of the sample as HLA‐B*38:02 and a novel allele.…”

Identification of the novel HLA‐B*27:04:06 allele in a Chinese bone marrow donor

“…To further confirm the alleles of HLA‐B locus in the sample, the HLA‐B*15 and HLA‐B*27 alleles were amplified with the allele‐specific primers separately as documented in our previous reports . The sequencing results showed HLA‐B alleles of the sample as HLA‐B*15:11 and a novel allele.…”