A novel hydrodynamic approach to the treatment of coronary artery disease

Abstract

DRPs improve perfusion to myocardium subserved by a flow-limiting coronary stenosis by decreasing microvascular resistance through an increase in capillary volume. Primary modulation of blood hydrodynamics and rheology to reduce microvascular resistance offers a novel approach to the treatment of ischaemic coronary syndromes.

A novel hydrodynamic approach of drag-reducing polymers to improve left ventricular hypertrophy and aortic remodeling in spontaneously hypertensive rats

“…In a canine model of flowlimiting coronary artery stenosis, DRPs improved perfusion to myocardium by decreasing microvascular resistance through an increase in capillary volume and red blood cell (RBC) velocity. 21 In our study, DRPs significantly increased blood flow and blood shear stress (Figure 2).…”

Rheological effects of drag-reducing polymers improve cerebral blood flow and oxygenation after traumatic brain injury in rats

“…Intravenous DRP were shown to significantly improve hemodynamics and survival in animal models of ischemic myocardium, 18 ischemic limb, 19 and hemorrhagic shock. 20 However, the effects of DRP have not been explored in brain circulation except for qualitative investigations performed over 30 years ago 21,22 and our first report on the use of DRP in the cerebral microcirculation in the hypertensive brain.…”

Drag reduction by polyethylene glycol in the tail arterial bed of normotensive and hypertensive rats

“…The exact in vivo mechanism of action of DRPs is unknown because of their complex fluid dynamic behavior in conjunction with the non-Newtonian physics of blood flow (39). Some hypotheses have been raised in the literature to explain the action of DRPs on the vascular system.…”