Drag reduction by polyethylene glycol in the tail arterial bed of normotensive and hypertensive rats

Bessa, Kleiber; Belletati, J.F.; Santos, Leonardo dos; Rossoni, Luciana Venturini; Ortiz, Jayme Pinto

doi:10.1590/s0100-879x2011007500071

Cited by 14 publications

(11 citation statements)

References 37 publications

(46 reference statements)

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“…To model an extremity artery in rodents, function of the proximal section of the rat tail artery, which is considered a medium‐sized artery has been studied (Bessa et al. ). Intriguingly, it has been demonstrated that the tail artery has a blunted response to PE‐induced constriction in the setting of 5/6 Nx (Brymora et al.…”

Section: Introductionmentioning

confidence: 99%

Differential regulation of nitric oxide synthase function in aorta and tail artery from 5/6 nephrectomized rats

et al. 2013

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Chronic renal failure (CRF) is associated with hypertension and concomitant endothelial dysfunction, enhanced vasoconstriction, and nitric oxide synthase (NOS) dysfunction. Vascular function in patients is assessed in peripheral extremity arteries like the finger arteries, whereas animal studies often use the centrally located aorta. Therefore, we examined whether peripheral tail artery and aortic NOS function are differentially regulated by blood pressure in rats with CRF. Using wire myography, arterial function was assessed in 16-week-old Sprague-Dawley rats that were subjected to 5/6 nephrectomy (Nx; arterial ligation model) 8 weeks earlier or non-Nx (control) rats. In aortas from Nx rats, endothelial-dependent vasorelaxation response to acetylcholine (ACh) was blunted and there was enhancement of phenylephrine (PE)-mediated vasoconstriction. Inversely, tail arteries from Nx rats had no change in endothelial function and reduced response to PE. Studies where arterial segments were incubated with the nonspecific NOS inhibitor, L-NAME, showed that Nx reduced NOS function in the aorta but increased NOS function in tail artery for both ACh and PE responses. Furthermore, the observed alterations in NOS function in both aorta and tail artery were abolished when mean arterial blood pressure, as assessed by telemetry, was maintained at normal levels in the 5/6 Nx rats using triple therapy: hydralazine (30 mg/kg per day), hydrochlorothiazide (10 mg/kg per day), and reserpine (0.5 mg/kg per day). In conclusion, differential changes of NOS function in central versus peripheral arteries in CRF are dependent upon hypertension.

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Section: Introductionmentioning

confidence: 99%

Differential regulation of nitric oxide synthase function in aorta and tail artery from 5/6 nephrectomized rats

et al. 2013

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“…The addition of a minute amount of additives into the blood circulatory system increases the blood velocity, tissue oxygenation, and perfusion by decreasing the vascular resistance [17,18]. This great performance is achieved without altering the blood vessels' tone [19,20], hemodynamic response of the arterioles [21,22], and rheological properties, i.e., viscosity and density, of blood [12]. Furthermore, Brands et al [23] reported the potential of the polymer additives in eliminating the particles that coagulate in the blood vessels.…”

Section: Introductionmentioning

confidence: 99%

“…However, most of the investigated additives are artificial polymers such as polyethylene oxide [24] and polyethylene glycol [12]. The integration of these artificial polymers into the human body has raised concerns from the society due to the toxic nature of these polymers [25,26].…”

Section: Introductionmentioning

confidence: 99%

Organic Additives for the Enhancement of Laminar Flow in a Brain‐Vessels‐Like Microchannel Assembly

2019

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Organic polymers were extracted from okra, aloe vera, and hibiscus leaves and used as drag-reducing additives (DRAs) to enhance the laminar flow in custommade microchannels that simulate the human brain vessels. The experiment was conducted using an open-loop microfluidic system. The flow enhancement performance was evaluated as the function of percentage of flow increment of mucilage additives at different concentrations. Okra mucilage showed greater flow enhancement performance at higher mucilage concentration while both aloe vera and hibiscus mucilage performed better at lower additive concentration. The findings prove the potential of these organic polymers as DRAs to enhance the blood flow.

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“…Arteries can also adapt to long-term physiological conditions by thinning or thickening the muscular layer, and altering the relative composition and organization of the various assemblies of structural proteins in process generally know as remodelling. Bessa et al (2011) showed that occurs remodelling in tail arterial bed from normotensive and hypertensive rats. As shown in Figure 1, the internal diameter of the proximal portion of the tail artery did not differ between Wistar rats and spontaneously hypertensive rats (SHR), whereas the diameter of the intermediate and distal portions of SHR tails arteries were significant smaller than those of normotensive rats.…”

Section: Introductionmentioning

confidence: 99%

“…Inset panels in the proximal tail artery photomicrographs of Wistar and SHR are amplified images showing the endothelial (E), medium (M) and adventitial (A) layers of the artery. Extracted from Bessa et al 2011. An aneurysm is defined as a focal dilation of a blood vessel when compared with the original artery. Aneurysms are widening of the lumen in any artery, most commonly in the aorta for fusiform types, and in the head for saccular types.…”

Section: Introductionmentioning

confidence: 99%

Biomechanical Factors Analysis in Aneurysm

Bessa¹,

Legendre²,

Prakasan³

2012

Fluid Dynamics, Computational Modeling and Applications

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Drag reduction by polyethylene glycol in the tail arterial bed of normotensive and hypertensive rats

Cited by 14 publications

References 37 publications

Differential regulation of nitric oxide synthase function in aorta and tail artery from 5/6 nephrectomized rats

Differential regulation of nitric oxide synthase function in aorta and tail artery from 5/6 nephrectomized rats

Organic Additives for the Enhancement of Laminar Flow in a Brain‐Vessels‐Like Microchannel Assembly

Biomechanical Factors Analysis in Aneurysm

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