Abstract:The development of new nanomaterials to promote wound healing is rising, because of their topical administration and easy functionalization with molecules that can improve and accelerate the process of healing. A nanocomposite of gold nanoparticles (AuNPs) functionalized with calreticulin was synthetized and evaluated. The ability of the nanocomposite to promote proliferation and migration was determined in vitro, and in vivo wound healing was evaluated using a mice model of diabetes established with streptozo… Show more
“…The articles were excluded because of study design, study topic (not diabetic wound), human studies, or studies not report wound healing as outcome measurements. Finally, 29 21,24‐51 studies that evaluated the effect of chitosan or alginate on diabetic wound healing were included. Figure 1 illustrated the trial selection process.…”
Section: Resultsmentioning
confidence: 99%
“…Table 1 presented the descriptive characteristics of the included articles. Overall, there were 23 trials 21,24‐30,32‐46 on chitosan, three trials on alginate, 31,47,48 and three trials on the combination of alginate and chitosan 49‐51 . The animal studies were conducted from 2002 and 2019.…”
Section: Resultsmentioning
confidence: 99%
“…Twenty‐three studies had insufficient information about how randomization was carried out in the experiment group and control group or provided inadequate report on the assignment of samples 21,24‐26,28‐37,42,44‐48,50,51 . Five studies did not give information about the randomization 27,38‐41 . All the included studies provided baseline characteristics including sex, age, the weight of the subjects, and wound area.…”
Section: Resultsmentioning
confidence: 99%
“…Only one trial provided sufficient reports on allocation concealment 47 . Four trials reported a nonrandom approach when housing the animals within the facility 27,30,31,38 . Four studies did not describe all measures used for random housing 16,30,31,38 .…”
Section: Resultsmentioning
confidence: 99%
“…Of included studies, eight studies reported the effect of chitosan‐based scaffolds on wound healing in cell studies 21,24,25,27‐31 . Escherichia coli , Pseudomonas aeruginosa , Bacillus subtilis , and Staphylococcus aureus 24,28 were used in the in vitro studies to examine the antibacterial activities of chitosan.…”
This systematic literature review was aimed to investigate the use of cell culture and animal models to evaluate the efficacy of alginate‐and chitosan‐based scaffolds on diabetic wound healing. We electronically searched the articles published until July 2019. The databases included five English databases such as PubMed, Web of Science, Embase, the Cochrane Library, CINAHL, and three Chinese databases like CNKI, WanFang Data, and VIP. The related articles were manually searched to identify studies that were not searched by electronic database searches. Twenty‐nine studies met the inclusion criteria. We divided the results into three groups: chitosan, alginate, and a combination of chitosan and alginate. Chitosan‐, alginate‐, and a combination of chitosan and alginate‐based scaffolds showed good intervention effects on wound healing. Chitosan‐based scaffolds were effective in diabetic skin wound healing. The effects of alginate and the combination of chitosan‐and alginate‐based scaffolds on diabetic skin wounds still need more research. However, due to the heterogeneity of animal and cell preclinical trials and the validity of the statistical analysis used in these studies, it is necessary to conduct a thorough study using well‐designed experiments to confirm these results. In addition, properly designed chitosan‐and/or alginate‐based scaffolds with thorough preclinical evaluations are required prior to clinical applications.
“…The articles were excluded because of study design, study topic (not diabetic wound), human studies, or studies not report wound healing as outcome measurements. Finally, 29 21,24‐51 studies that evaluated the effect of chitosan or alginate on diabetic wound healing were included. Figure 1 illustrated the trial selection process.…”
Section: Resultsmentioning
confidence: 99%
“…Table 1 presented the descriptive characteristics of the included articles. Overall, there were 23 trials 21,24‐30,32‐46 on chitosan, three trials on alginate, 31,47,48 and three trials on the combination of alginate and chitosan 49‐51 . The animal studies were conducted from 2002 and 2019.…”
Section: Resultsmentioning
confidence: 99%
“…Twenty‐three studies had insufficient information about how randomization was carried out in the experiment group and control group or provided inadequate report on the assignment of samples 21,24‐26,28‐37,42,44‐48,50,51 . Five studies did not give information about the randomization 27,38‐41 . All the included studies provided baseline characteristics including sex, age, the weight of the subjects, and wound area.…”
Section: Resultsmentioning
confidence: 99%
“…Only one trial provided sufficient reports on allocation concealment 47 . Four trials reported a nonrandom approach when housing the animals within the facility 27,30,31,38 . Four studies did not describe all measures used for random housing 16,30,31,38 .…”
Section: Resultsmentioning
confidence: 99%
“…Of included studies, eight studies reported the effect of chitosan‐based scaffolds on wound healing in cell studies 21,24,25,27‐31 . Escherichia coli , Pseudomonas aeruginosa , Bacillus subtilis , and Staphylococcus aureus 24,28 were used in the in vitro studies to examine the antibacterial activities of chitosan.…”
This systematic literature review was aimed to investigate the use of cell culture and animal models to evaluate the efficacy of alginate‐and chitosan‐based scaffolds on diabetic wound healing. We electronically searched the articles published until July 2019. The databases included five English databases such as PubMed, Web of Science, Embase, the Cochrane Library, CINAHL, and three Chinese databases like CNKI, WanFang Data, and VIP. The related articles were manually searched to identify studies that were not searched by electronic database searches. Twenty‐nine studies met the inclusion criteria. We divided the results into three groups: chitosan, alginate, and a combination of chitosan and alginate. Chitosan‐, alginate‐, and a combination of chitosan and alginate‐based scaffolds showed good intervention effects on wound healing. Chitosan‐based scaffolds were effective in diabetic skin wound healing. The effects of alginate and the combination of chitosan‐and alginate‐based scaffolds on diabetic skin wounds still need more research. However, due to the heterogeneity of animal and cell preclinical trials and the validity of the statistical analysis used in these studies, it is necessary to conduct a thorough study using well‐designed experiments to confirm these results. In addition, properly designed chitosan‐and/or alginate‐based scaffolds with thorough preclinical evaluations are required prior to clinical applications.
Diabetic foot ulcers (DFUs) are chronic severe complications of diabetes disease and remain a worldwide clinical challenge with social and economic consequences. Diabetic wounds can cause infection, amputation of lower extremities, and even death. Several factors including impaired angiogenesis, vascular insufficiency, and bacterial infections result in a delayed process of wound healing in diabetic patients. Treatment of wound infections using traditional antibiotics has become a critical status. Thus, finding new therapeutic strategies to manage diabetic wounds is urgently needed. Nanotechnology has emerged as an efficient approach for this purpose. This review aimed to summarize recent advances using nanotechnology for the treatment of diabetic wounds.
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