Nanotechnology‐driven advances in the treatment of diabetic wounds

Abstract

Diabetic foot ulcers (DFUs) are chronic severe complications of diabetes disease and remain a worldwide clinical challenge with social and economic consequences. Diabetic wounds can cause infection, amputation of lower extremities, and even death. Several factors including impaired angiogenesis, vascular insufficiency, and bacterial infections result in a delayed process of wound healing in diabetic patients. Treatment of wound infections using traditional antibiotics has become a critical status. Thus, finding new therapeutic strategies to manage diabetic wounds is urgently needed. Nanotechnology has emerged as an efficient approach for this purpose. This review aimed to summarize recent advances using nanotechnology for the treatment of diabetic wounds.

Glucose/ROS cascade-responsive ceria nanozymes for diabetic wound healing

“…The rate of disappearance was not as rapid as that of free IR783, but it was faster than that in animals injected with IR783-CHA. This result is consistent with a model in which GOx released from CHA@GOx was controlled by blood glucose levels [ 36 ], and GOx-mediated degradation of glucose to glucuronic acid resulted in a local decrease in pH that gradually disrupted the structure of the nanozymes. Therefore, this disruption would result in an acceleration of the release and degradation of IR783-CHA@GOx.…”

“…In recent years, nanotechnology has been increasingly applied to the biomedical field [ 36 ], especially nanomaterials for ROS scavenging [ 37 ]. Among them, ceria nanoparticles are rich in enzymatic activity and capable of scavenging a wide range of ROS that have been widely explored [ 38 ].…”

Antimicrobial Lignin-Based Polyurethane/Ag Composite Foams for Improving Wound Healing

“…The antimicrobial activity of Ag NPs has been established since the 19th century. The incorporation of Ag NPs into polyurethane provides an effective strategy to endow the dressings with antibacterial activity. − Nevertheless, traditional synthesis methods of Ag NPs, such as ascorbic acid/citrate reduction − and plasma solution process, require high-temperature and high-pressure conditions. Nowadays, more attention has been paid to the preparation of Ag NPs by environmentally friendly methods (using natural compounds , with metal-reducing capabilities as reducing agents).…”

Recent Progress in Development of Dressings Used for Diabetic Wounds with Special Emphasis on Scaffolds

“…Electrospinning STZ (70 mg/kg) Male SD rats (i) Scaffold loaded with glucophage exhibited 6-folds and 2-folds decrease in wound area as compared to collagen/PLGA nanofibrous membrane and conventional gauze sponge-treated groups [187] 7.…”