A Novel Fullerene‐Pyrrole‐Pyrrole‐3‐Carboxylic Acid Nanocomposite Modified Molecularly Imprinted Impedimetric Sensor for Dopamine Determination in Urine

Uygun, Hilmiye Deniz Ertuğrul; Demir, M. Nalan

doi:10.1002/elan.202060023

Cited by 13 publications

(3 citation statements)

References 17 publications

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“…For instance, a novel electrochemical nanobiosensor based on zinc oxide with embedded polyvinyl alcohol nanoplatelets was developed for the determination of dopamine over a broad range, with a limit of detection of 5.0 nM [ 80 ]. In another case, a fullerene-pyrrole-pyrrole-3-carboxylic acid nanocomposite-modified molecularly imprinted impedimetric nanobiosensor was developed for the detection of dopamine in urine [ 81 ]. The study exhibited impressive sensitivity and enabled the detection of dopamine with a remarkable LOD value of 8.77 ng/mL.…”

Section: Recent Advances In Electrochemical Nanobiosensors For Neurot...mentioning

confidence: 99%

An Updated Review on Electrochemical Nanobiosensors for Neurotransmitter Detection

Choi,

Yoon

2023

Biosensors

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Neurotransmitters are chemical compounds released by nerve cells, including neurons, astrocytes, and oligodendrocytes, that play an essential role in the transmission of signals in living organisms, particularly in the central nervous system, and they also perform roles in realizing the function and maintaining the state of each organ in the body. The dysregulation of neurotransmitters can cause neurological disorders. This highlights the significance of precise neurotransmitter monitoring to allow early diagnosis and treatment. This review provides a complete multidisciplinary examination of electrochemical biosensors integrating nanomaterials and nanotechnologies in order to achieve the accurate detection and monitoring of neurotransmitters. We introduce extensively researched neurotransmitters and their respective functions in biological beings. Subsequently, electrochemical biosensors are classified based on methodologies employed for direct detection, encompassing the recently documented cell-based electrochemical monitoring systems. These methods involve the detection of neurotransmitters in neuronal cells in vitro, the identification of neurotransmitters emitted by stem cells, and the in vivo monitoring of neurotransmitters. The incorporation of nanomaterials and nanotechnologies into electrochemical biosensors has the potential to assist in the timely detection and management of neurological disorders. This study provides significant insights for researchers and clinicians regarding precise neurotransmitter monitoring and its implications regarding numerous biological applications.

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Section: Recent Advances In Electrochemical Nanobiosensors For Neurot...mentioning

confidence: 99%

An Updated Review on Electrochemical Nanobiosensors for Neurotransmitter Detection

Choi,

Yoon

2023

Biosensors

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“…Impedimetric measurement is also possible with an SPE, and the neurotransmitter biomarker dopamine was measured at a carbon SPE by monitoring surface charge transfer resistance on MIP binding. The special feature of this work was that a synergistic binding combination of pyrrole and pyrrole‐3‐carboxylic acid were used to create the MIP along with a fullerene to raise conducting surface area [173]. SPEs can also be used as solid contact potentiometric sensors, and in one example, a SWCNT connected PVC with an embedded MIP for the bile acid sodium deoxycholate was used; the electrode was a carbon SPE surface [174].…”

Section: Screen Printed Electrodes For Outreachmentioning

confidence: 99%

Molecular Imprinted Polymer Modified Electrochemical Sensors for Small Drug Analysis: Progress to Practical Application

Feroz

Vadgama

2020

Electroanalysis

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Molecular imprinted polymers (MIPs) are tailor made from synthetic polymers and designed to mimic the recognition properties of natural biological affinity molecules. MIPs incorporate binding motifs complementary to target organic molecule shape and functional groups in order to mimic the complex binding surfaces of natural macromolecules. This confers selectivity and specificity, with the added advantage of artificial MIP polymer stability and ready adaptability to the fabrication and creation of miniaturised affinity interfaces for electrochemical sensing and extra‐laboratory testing. Their generic capability as robust sorbent phases for drug extraction and concentration allows for targeted, interfacial interrogation by the active electrochemical surface. A wide range of electrochemical sensing strategies has also been advanced in recent years, which is covered by this review. The review covers MIP functional principles, examples of MIP preparative routes and final assay outcomes for the measurement of small molecule drugs of biomedical, and also of potential environmental relevance. Some small molecules as examples of toxin and contaminant measurement are also given. A historic background to MIP development is provided, but the review mainly focuses on electrochemical sensor advances in the last five years.

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“…However, the electrons of the imine group are not available to establish efficient hydrogen bonds. Consequently, many authors usually propose the use of Ppy in combination with alternative polymers and additives such as o-phenylenediamine [ 21 ], chitosan [ 22 ], and carboxylic acids [ 23 ] to increase the number and diversity of interactions between the imprinted polymer and the template.…”

Section: Introductionmentioning

confidence: 99%

A Molecularly Imprinted Polypyrrole/GO@Fe3O4 Nanocomposite Modified Impedimetric Sensor for the Routine Monitoring of Lysozyme

et al. 2022

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Lysozyme (LYS) applications encompass anti-bacterial activity, analgesic, and anti-inflammatory effects. In this work, a porous framework that was based on the polymerization of pyrrole (PPy) in the presence of multi-functional graphene oxide/iron oxide composite (GO@Fe3O4) has been developed. Oxygen-containing and amine groups that were present in the nanocomposite were availed to assembly LYS as the molecularly imprinted polymer (MIP) template. The synthesized material (MIPPy/GO@Fe3O4) was electrodeposited on top of a gold microelectrode array. Transmission electron microscopy (TEM) and X-ray photoelectron spectroscopy (XPS) were used to confirm the adequate preparation of GO@Fe3O4, and the characterization of the resulting molecularly imprinted electrochemical sensor (MIECS) was carried out by electrochemical impedance spectrometry (EIS), FT-IR analysis, and scanning electron microscopy (SEM). The impedimetric responses were analyzed mathematically by fitting to a Q(Q(RW)) equivalent circuit and quantitative determination of LYS was obtained in a linear range from 1 pg/mL to 0.1 µg/mL, presenting good precision (RSD ≈ 10%, n = 5) and low limit of detection (LOD = 0.009 pg/mL). The fabrication of this device is relatively simple, scalable, rapid, and economical, and the sensor can be used up to nine times without disintegration. The MIECS was successfully applied to the determination of LYS in fresh chicken egg white sample and in a commercial drug, resulting in a straightforward platform for the routine monitoring of LYS.

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A Novel Fullerene‐Pyrrole‐Pyrrole‐3‐Carboxylic Acid Nanocomposite Modified Molecularly Imprinted Impedimetric Sensor for Dopamine Determination in Urine

Cited by 13 publications

References 17 publications

An Updated Review on Electrochemical Nanobiosensors for Neurotransmitter Detection

An Updated Review on Electrochemical Nanobiosensors for Neurotransmitter Detection

Molecular Imprinted Polymer Modified Electrochemical Sensors for Small Drug Analysis: Progress to Practical Application

A Molecularly Imprinted Polypyrrole/GO@Fe3O4 Nanocomposite Modified Impedimetric Sensor for the Routine Monitoring of Lysozyme

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