In this chapter we discus molecular imprinting technology MIT , molecular imprinted polymers MIPs , and their compatibility on a proper transducer to construct a sensing system. Molecularly imprinted sensors MISens , in other words, artificial receptor-based sensors synthesized in the presence of the target molecule, are capable of sensing target molecules by using their specific cavities and are compatible with the target molecule. This MIP technology is a viable alternative of artificial receptor technology, and the sensor technology is capable of detecting any kind of molecule without pre-analytic preparations. In this chapter, you can find examples, sensor construction techniques and fundamentals of MIP and sensor combinations to look forward in your studies. For sensor technology, we explained and discussed the new sensing technologies of MIP-based electrochemical, optical especially surface plasmon resonance, SPR , and piezoelectric techniques. Therefore, this chapter presents a short guideline of MISens.
Abstract:In this study, undoped and Zn-doped SnO2 nanoparticles in different concentrations were synthesized by flame spray pyrolysis (FSP) technique. The produced particles were post-annealed after FSP process at 600 °C in order to obtain a crystalline structure. The structural analysis of the produced powders was performed by X-Ray Diffraction (XRD) methods. The surface morphology of the nanoparticles was identified using scanning electron microscopy (SEM). In addition, photocatalytic degradation of aqueous methylene blue (MB) solutions were evaluated using undoped and Zn-doped SnO2 nanoparticles under UV light illumination. Photocatalytic degradation of the MB solutions followed the pseudo-first-order-kinetics and the effect of the Zn doping amount on the photocatalytic reaction was investigated.
In this study, we designed an electrochemical impedance based sensor by using molecularly imprinted fullerene modified pyrrole‐pyrrole‐3‐carboxylic acid copolymers on screen printed carbon electrode to monitor dopamine in real urine samples. All modifications were characterized by electrochemical impedance spectroscopy (EIS) and Scanning Electron Microscopy (SEM). Performance parameters of the developed sensor system were determined by calibration curve performed between 25 ng/mL and 250 ng/mL (R2= 0.9939). LOD and LOQ were 8.77 ng/mL and 26.6 ng/mL, respectively. The developed sensor method was compared with ELISA. The regression analysis between ELISA and the sensor analysis showed good correlation with R2= 0.979
In this study, a molecularly imprinted sensor technology is engineered to detect glucose in real blood samples by chronoimpedimetrically. The imprinting process of glucose (Glc) was carried out by electrochemical polymerization of aminophenylboronic acid (APBA) and pyrrole (Py) by performing cyclic voltammetry (CV). Afterwards, glucose molecule was removed from imprinted surface by 5 % acetic acid to reveal glucose imprinted cavities. Electrochemical Impedance Spectroscopy (EIS) was used to characterize sensor modification steps and glucose removal. Glucose monitoring process was carried out chronoimpedimetrically(CI) for the first time in real blood samples. Calibration curve was prepared between 20–800 mg/dL. The standard deviations of the 18 calibration curves R2 were calculated as 0.9866±0.0066 to assess reproducibility. Recovery was calculated by using 105 mg/dL Glc Serum Sample, which was monitored by auto analyzer and into this sample 50 mg/dL Glc added and our sensor response was 147.92±2.43 mg/dL, 98.6±1.62 % (n=5). Non‐imprinted (NIP) sensor gave no signal for the glucose concentration.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.