A novel electronic micro-viscometer

Maurya, Ranjan Kumar; Kaur, Rajvinder; Kumar, Ramesh; Agarwal, Ajay

doi:10.1007/s00542-019-04357-8

Cited by 8 publications

(8 citation statements)

References 26 publications

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“…The microviscometers with controllable electronics were developed by comparing the capacitance values between the empty microchannel and in presence of the fluid. Based on these capacitance values, viscosity was predicted with the help of the mathematical model reported by Maurya et al [91]. Further, it was claimed that less than 100 μl of fluid was necessary to measure viscosity.…”

Section: Electro-mechanical Methodsmentioning

confidence: 99%

Microfluidic viscometers for biochemical and biomedical applications: A review

2021

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In recent times, microviscometers have been exploited for widespread and diverse detection applications such as sensing adulteration in various fluids used in day-to-day life, diagnostics in the biomedical domain involving human bodily fluids, pharmaceuticals, and biochemical analysis. The microviscometers have the proven capability for being employed as point-of-care devices, which can be achieved by automating them by integrating various microelectronic components, such as integrated circuits, and sensors, on printed circuit boards. In the past few decades, several fabrication techniques have been reported to measure relative viscosity in the microfluidic domain. Moreover, considerable innovation in this direction has observed a lot of improvements and advancements leading to the reduction of cost, and size. Also, the microfluidic viscometer provides simple and rapid detection which makes them more flexible and versatile in the biomedical domain. The microfluidic device unveils numerous features such as easy-to-use, portable, transparency in operation, and rapid detection with a marginal reaction volume. In this review, the development of various microfluidicbased viscometers and their applications, primarily in biomedical applications, have been discussed. Using the state-of-art approach, such microviscometers can be manufactured on a commercial scale for point-of-care diagnosis. This review summarizes the limitations in conventional viscometers and value-chain, comprising designs, fabrication techniques, and other related methodologies, to develop the microviscometers that have been presented. It has been observed that the interest in microfluidicbased viscometers has incredible applications for regular monitoring and personalized point-of-care devices in a controlled and selective manner.

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Section: Electro-mechanical Methodsmentioning

confidence: 99%

Microfluidic viscometers for biochemical and biomedical applications: A review

2021

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“…They also observed, as expected, that the microfluidic rheometer was able to reach imposed values of the shear rate up to γ ≈ 10 4 s −1 , an order of magnitude above the values explored by conventional rheometers. Another system was recently developed by Maurya et al [16], where the fluid flowed without the need of a syringe pump in a microfluidic chamber made of a top part of glass and a bottom part of oxidised silicon wafer. This device was used to measure a single value of viscosity for several diesel/biodiesel compositions, and the resulting data were compared with those available from the literature, finding good agreement, as show in Figure 2.…”

Section: Micro-electro-mechanical Systems (Mems)mentioning

confidence: 99%

“…This device was used to measure a single value of the viscosity for samples containing lysozyme, human serum albumin and bovine serum albumin, all having a viscosity falling in the range of 0.5-10 cP. Based on the data presented so far, both the microfluidic rheometer introduced by Maurya et al [16] and by Puneeth et al [21] are currently usable for rapid order-of-magnitude measurements rather than detailed rheological characterisation. Pan and Arratia [17] presented a microfluidic slit rheometer made of polydimethylsiloxane (PDMS), where the pressure sensor on the upper wall was also made of a flexible PDMS membrane containing silver and black carbon particles (Figure 2a,b).…”

Section: Micro-electro-mechanical Systems (Mems)mentioning

confidence: 99%

A Review of Microfluidic Devices for Rheological Characterisation

Giudice

2022

Micromachines

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The rheological characterisation of liquids finds application in several fields ranging from industrial production to the medical practice. Conventional rheometers are the gold standard for the rheological characterisation; however, they are affected by several limitations, including high costs, large volumes required and difficult integration to other systems. By contrast, microfluidic devices emerged as inexpensive platforms, requiring a little sample to operate and fashioning a very easy integration into other systems. Such advantages have prompted the development of microfluidic devices to measure rheological properties such as viscosity and longest relaxation time, using a finger-prick of volumes. This review highlights some of the microfluidic platforms introduced so far, describing their advantages and limitations, while also offering some prospective for future works.

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“…Advantages such as low power consumption, biocompatibility, and small size [1] have led to the use of MEMS in the medical field extensively for therapeutic systems, precision surgery, Lab-on-Chip, Drug delivery systems, detection of diseases, tissue engineering, micro-fluids, medical implants, and others. MEMS in the medical field uses different actuation methods like optical, piezoresistive, electrostatic, or piezoelectric for diagnosing various diseases such as hepatitis virus, [2] cancer, [3] virus detection, [4][5][6] Parkinson's, [7] HIV, [8] swine flu, [9] tuberculosis, [10] and many more.…”

Section: Introductionmentioning

confidence: 99%

Polymer‐Based MEMS Sensor for Label‐Free Chikungunya Virus Detection

Niranjan

Gupta

Rajoria

2023

Macromolecular Symposia

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Piezoelectric MEMS (Micro-Electro-Mechanical Systems) Cantilevers have successfully been used in a wide variety of applications in recent years. This paper is a simulation-based study on Micro-cantilever based Piezoelectric MEMS biosensors for Chikungunya Virus (CHIKV) detection. In addition to providing early detection, the proposed method is label-free, faster, and more reliable. The proposed biosensor detects CHIKV E2 protein via MEMS Sensor. The basic principle involves using piezoelectric material on a micro-cantilever for biomaterial detection. A piezoelectric MEMS cantilever is simulated in COMSOL Multiphysics and compared for voltage, stress, and displacement for three materials (silicon, gold, and PDMS). Analytical equations are derived. Post-processing for biosensor design is done in SIMULINK. Simulated voltage, stress, and displacement show a linear relationship with the viral load. PDMS also provided the highest voltage and displacement among the three materials used for MEMS simulation. The graphs show the comparison between simulated and analytical values. Simulation results are also compared to clinical results to prove the biosensor's validity. MEMS Biosensor performance matches with the RT-PCR results, with the added advantage of faster results. Diagnostic tests in the medical field can be performed using the proposed biosensor.

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A novel electronic micro-viscometer

Cited by 8 publications

References 26 publications

Microfluidic viscometers for biochemical and biomedical applications: A review

Microfluidic viscometers for biochemical and biomedical applications: A review

A Review of Microfluidic Devices for Rheological Characterisation

Polymer‐Based MEMS Sensor for Label‐Free Chikungunya Virus Detection

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