A novel ECL sensor based on a boronate affinity molecular imprinting technique and functionalized SiO2@CQDs/AuNPs/MPBA nanocomposites for sensitive determination of alpha-fetoprotein
“…To further improve the selectivity for the determination of a-fetoprotein, a boronate affinity molecular imprinting technique was used based on SiO 2 /CDs/gold nanoparticle composites as the ECL labels. 167 The proposed ECL sensor showed excellent performance, especially in terms of selectivity in serum samples, indicating its great potential for application in clinical diagnostics. Rolling circle amplification (RCA) has been often used as an isothermal amplification procedure to produce a linear concatenated DNA molecule containing up to 1000 complementary copies of the circular DNA.…”
This review summarizes the recent development of ECL sensors based on carbon-based dots. Particularly, various analytical approaches involving metal ions, small molecules, proteins, nucleic acids and cells are thoroughly presented.
“…To further improve the selectivity for the determination of a-fetoprotein, a boronate affinity molecular imprinting technique was used based on SiO 2 /CDs/gold nanoparticle composites as the ECL labels. 167 The proposed ECL sensor showed excellent performance, especially in terms of selectivity in serum samples, indicating its great potential for application in clinical diagnostics. Rolling circle amplification (RCA) has been often used as an isothermal amplification procedure to produce a linear concatenated DNA molecule containing up to 1000 complementary copies of the circular DNA.…”
This review summarizes the recent development of ECL sensors based on carbon-based dots. Particularly, various analytical approaches involving metal ions, small molecules, proteins, nucleic acids and cells are thoroughly presented.
“…Carbon quantum dots (CQDs) are spherical carbon nanomaterials, which have a wide absorption band, narrow emission band and high quantum yield 28 and have received extensive attention in uorescence sensors, 29 biosensing, 30 chemical imaging, 31 drug applications, 32 photocatalysis 33 and electrocatalysis. 34 CQDs have already become a potential competitor to traditional semiconductor quantum dots.…”
A novel CQDs@MIL-125(Ti) photocatalyst had been synthesized by a facile solvothermal process for the degradation of TC. The possible degradation mechanism was proposed based on the active species trapping experiments.
“…The dose-response curve for this system displayed a wide linear range (0–1.2 × 10 −6 M) even in the presence of common ionic and molecular interfaces that can be found in biofluids, yielding an LoD of 100−150 × 10 -9 M. All results were validated with HPLC, which emphasizes that the assay is not only interesting because it is handheld and requires little instrumentation but also has enough diagnostic relevance. Over the past two years alone, many similar QD-based MIP assays have been developed for various purposes including medical diagnostics [ [216] , [217] , [218] ], food safety [ 219 , 220 ] and environmental screening [ 221 , 222 ]. Fig.…”
Highlights
The review aims to summarize recent commercially interesting innovations in MIP-based sensor design.
In addition to sensors, commercially viable assays based on MIPs are analysed and recent advances are summarized and discussed.
The review also analyses how commercial MIP companies could contribute to a next step in the commercialization of MIP-based detection systems.
The review contains a critical analysis and discussion on MIP-based sensors and assay commercialization as well as an outlook/recommendation for the future.
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