A novel device for capturing breath samples for solvent analysis

Analytical challenges in breath analysis and its application to exposure monitoring

“…One option comprises an insulated aluminum tube that holds a collapsible Tedlar sampling bag (85 mL). After collecting end-tidal breath in the bag, an adsorption tube is attached to the sampling tube to adsorb the volatiles in breath [81][82][83]. A recent modification comprises an insulated aluminum tube maintained at 40-45ºC to prevent condensation of the water vapor [84].…”

“…Pre-concentration on solid sorbents followed by thermal desorption (TD) is the most frequent method for the analysis of VOCs in breath samples [9][10][11][12][13]16,[19][20][21][22][23][24][25][26][27][28][43][44][45]47,55,62,75,[81][82][83][84][85]95,96]. Sorbent traps present the advantages that they can be prepared on a micro-scale and coupled on-line with a GC system to allow near real-time measurements [97][98][99][100][101], and the sorbent configuration can be easily changed to adapt to different compounds.…”

A Field Method for Sampling Toluene in End-Exhaled Air, as a Biomarker of Occupational Exposure: Correlation with Other Exposure Indices.

“…More than 200 compounds have been identified in normal human breath by gas chromatography coupled with mass spectrometry 4) . Several methods have been proposed for sampling and collecting exhaled air samples: glass, aluminium tubes or SUMMA stainless steel canisters have been used for the sampling of alveolar air and plastic bags mainly for the total air [5][6][7][8][9][10][11] . Successively the air is transferred onto the analytical system directly or through solid sorbents that are thermally desorbed; solid-phase microextraction (SPME) technique has been also applied 12) .…”

Breath Analysis: Analytical Methodologies and Clinical Applications

“…Most are simple combinations of valves and connections that the subject under test uses to fill a sampling bag or a syringe [24][25][26], or a preevacuated stainless steel canister [27]. In the latter case, the subjects themselves control the sampling by opening a manual valve through which their breath is sucked into the canister.…”