Alzheimer's disease (AD) is an advanced neurodegenerative disease of the brain that affects the nerve system of brain. Previously, several feature extraction and classification methods were discussed, but that methods provide high over fitting problem, which leads to minimization of detection accuracy. To overcome these issues, the multi class classification of AD diseases using bag of deep feature reduction technique and twin support vector machine classifier (TSVM) optimized with gradient decent optimizer is proposed in this manuscript for classifying the AD disease as severe AD, mild cognitive impairment, healthy control. At first, the input EEG signals are pre-processed. To decrease the execution time and processing time with feature size, a bag of deep features reduction technique is used. The reduced feature signals are classified by optimized TSVM. The simulation process is implemented in MAT-LAB environment. The proposed model achieves higher accuracy 33.84%, 28.93%, 33.03%, 27.93%, higher precision 22.87%, 16.97%, 16.97%, and 36.97%, compared with the existing methods, such as piecewise aggregate approximation support vector machine (MCC-EEG-PAA-SVM), convolutional neural network (MCC-EEG-CNN), conformal kernel-based fuzzy support vector machine (MCC-EEG-CKF-SVM), Pearson correlation coefficient-based feature selection strategy with linear discriminant analysis classifier (MCC-EEG-PCC-LDA). K E Y W O R D S bag of deep features (BoDrF) reduction, gradient decent optimizer, multi class classification, twin support vector machine classifier
INTRODUCTIONAlzheimer's disease is a permanent neurodegenerative disease and the most predominant form of dementia. [1][2][3][4] The initial symptoms of the AD disease contain disremembering the current actions. When the disease grows, a person who affected by Alzheimer's disease also grows severe memory impairment and drops the capability to carry everyday jobs. [5][6][7] AD caused difficult to absorb as well as thinking. The indications of this AD diseases are severe in the last stage. If the AD diseases grow to its last stage, it destroys brain nerves systems. [8][9][10][11][12][13] When the brain functions are totally affected, it may leads to death. Presently, more than 46.8 million peoples affected dementia in the world, it is predictable to spread 74.7 million in 2030. [14][15][16]