A novel concept for detoxification: Complexation between aconitine and liquiritin in a Chinese herbal formula (‘Sini Tang’)

Peter, Karoline; Schinnerl, Johann; Felsinger, Susanne; Brecker, Lothar; Bauer, Rudolf; Breiteneder, Heimo; Xu, Riurong; Ma, Yan

doi:10.1016/j.jep.2013.07.022

Cited by 46 publications

(30 citation statements)

References 23 publications

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“…The decoction was performed twice by cooking gently for 30 min each. The two obtained decocts were combined, filtered, and stored at 4°C before administration to rats [16]. …”

Section: Methodsmentioning

confidence: 99%

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Anti‐Inflammatory Effects of the Chinese Herbal Formula Sini Tang in Myocardial Infarction Rats

Liu

Peter

Shi

et al. 2014

Evidence-Based Complementary and Alternative Medicine

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The aim of this study was to evaluate the anti-inflammatory profiling of the Chinese herbal formula Sini Tang (SNT) in myocardial infarction (MI) rats. SNT, a decoction consisting of four herbs: Aconitum carmichaelii, Cinnamomum cassia, Zingiber officinale, and Glycyrrhiza uralensis, was characterized as a remedy to treat syndromes corresponding to heart failure and MI in China. Potential biomarkers, which reflect the extent of myocardial necrosis and correlate with cardiac outcomes following MI, such as atrial natriuretic peptide (ANP), high sensitivity C-reactive protein (hs-CRP), and proinflammatory cytokines such as tumor necrosis factor-α, interleukin-6, and interleukin-1β (TNF-α, IL-6, and IL-1β) were determined in plasma, serum, and in myocardial tissue of MI rats after treatment with SNT. Our data indicate that SNT decreased significantly the levels of hs-CRP, TNF-α, IL-6, and IL-1β in MI rats. SNT decreased the expression of ANP levels in plasma and increased the vascular active marker nitric oxide, which limits vascular inflammation. In addition, SNT could decrease the expression of endothelin-1 levels in rat plasma post-MI. Our data suggest that the Chinese herbal formula SNT has the potential to improve cardiac function after MI. SNT may be a candidate for treating MI and its associated inflammatory responses.

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“…The decoction was performed twice by cooking gently for 30 min each. The two obtained decocts were combined, filtered, and stored at 4°C before administration to rats [16]. …”

Section: Methodsmentioning

confidence: 99%

“…ex DC. Fabaceae) [14], was used in preliminary and previous studies in a MI rat model [15, 16] (Table 1). …”

Section: Introductionmentioning

confidence: 99%

Anti‐Inflammatory Effects of the Chinese Herbal Formula Sini Tang in Myocardial Infarction Rats

Liu

Peter

Shi

et al. 2014

Evidence-Based Complementary and Alternative Medicine

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“…It was found that liquiritin exist mainly as glucoside form of bioactive compound [4,5], while liquiritigenin, an aglycone of liquiritin is present in small amounts in G. uralensis [1]. There are several studies on their beneficial effects including prevention of carcinogenesis [6,7], hepatoprotective effects [1], and anti-inflammatory effects [4].…”

Section: Introductionmentioning

confidence: 99%

Production of Liquiritigenin with Cell-based Biotransformation and Its Anti-Aging Activity

Hwang¹,

Jeong²,

Park

2015

KSBB Journal

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In this study, an efficient whole cell-based biotransformation for the production of liquiritigenin was developed using Laetiporus sulphureus CS0218 as biocatalyst and aqueous extracts of Glycyrrhiza uralensis as co-substrate, respectively. In order to determine the efficacy of this method, the optimal bioconversion conditions including mycelial growth, three important enzyme activities (β-glucosidase, α-rhamnosidase and β-xylosidase), and apparent viscosity of culture broth were monitored. After optimization, aqueous extracts of G. uralensis were added to the culture medium to directly produce algycone liquiritigenin. By applying this strategy, 67.5% of liquiritin was converted to liquiritigenin at pH 3.0 after 9 days of incubation and finally liquiritigenin was purified from the reaction mixture. And then, their biological activities including anti-oxidant and superoxide dismutase were observed. In fact, purified liquiritigenin was capable of bi-directional functions (i.e., either up-regulation or down-regulation of SIRT1 which is associated with aging). The results indicate that this strategy would be beneficial to produce biologically active liquiritigenin and could be used in pharmaceutical, cosmetic and food applications.

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“…ex DC. (licorice) [17]. The SNT decoction has been used to improve blood circulation, remove blood stasis, and treat myocardial damage in Chinese clinics [2, 8, 13].…”

Section: Introductionmentioning

confidence: 99%

Traditional Formula, Modern Application: Chinese Medicine Formula Sini Tang Improves Early Ventricular Remodeling and Cardiac Function after Myocardial Infarction in Rats

Liu

Peter

Shi

et al. 2014

Evidence-Based Complementary and Alternative Medicine

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Sini Tang (SNT) is a traditional Chinese herbal formula consisting of four different herbs: the root of Aconitum carmichaelii, the bark of Cinnamomum cassia, the rhizome of Zingiber officinale, and the root of Glycyrrhiza uralensis. This study aims to evaluate the improvement of early ventricular remodeling and cardiac function in myocardial infarction (MI) rats by SNT. A MI model was established by ligation of the left anterior descending coronary artery. Following treatment for 4 weeks, ultrasonic echocardiography was performed. Myocardial histopathological changes were observed using haematoxylin and eosin staining. Collagens (type I and type III), transforming growth factor-β1 (TGF-β1), and Toll-like receptors (TLR-2 and TLR-4) were measured in plasma, serum, and myocardial tissue. SNT treatment decreased the infarct size, the left ventricular cavity area/heart cavity area ratio, and the left ventricle dimension at end systole and increased the left ventricular ejection fraction. SNT reduced the levels of TLR-2 and TLR-4 in myocardial tissue significantly and decreased the collagens content in serum and in myocardial tissue. SNT could partially reduce the level of TGF-β1 in serum and in myocardial tissue. Our data suggest that the Chinese medicine formula SNT has the potential to improve early ventricular remodeling and cardiac function after MI.

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A novel concept for detoxification: Complexation between aconitine and liquiritin in a Chinese herbal formula (‘Sini Tang’)

Cited by 46 publications

References 23 publications

Anti‐Inflammatory Effects of the Chinese Herbal Formula Sini Tang in Myocardial Infarction Rats

Anti‐Inflammatory Effects of the Chinese Herbal Formula Sini Tang in Myocardial Infarction Rats

Production of Liquiritigenin with Cell-based Biotransformation and Its Anti-Aging Activity

Traditional Formula, Modern Application: Chinese Medicine Formula Sini Tang Improves Early Ventricular Remodeling and Cardiac Function after Myocardial Infarction in Rats

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