Traditional Formula, Modern Application: Chinese Medicine Formula Sini Tang Improves Early Ventricular Remodeling and Cardiac Function after Myocardial Infarction in Rats

Abstract

Sini Tang (SNT) is a traditional Chinese herbal formula consisting of four different herbs: the root of Aconitum carmichaelii, the bark of Cinnamomum cassia, the rhizome of Zingiber officinale, and the root of Glycyrrhiza uralensis. This study aims to evaluate the improvement of early ventricular remodeling and cardiac function in myocardial infarction (MI) rats by SNT. A MI model was established by ligation of the left anterior descending coronary artery. Following treatment for 4 weeks, ultrasonic echocardiography was performed. Myocardial histopathological changes were observed using haematoxylin and eosin staining. Collagens (type I and type III), transforming growth factor-β1 (TGF-β1), and Toll-like receptors (TLR-2 and TLR-4) were measured in plasma, serum, and myocardial tissue. SNT treatment decreased the infarct size, the left ventricular cavity area/heart cavity area ratio, and the left ventricle dimension at end systole and increased the left ventricular ejection fraction. SNT reduced the levels of TLR-2 and TLR-4 in myocardial tissue significantly and decreased the collagens content in serum and in myocardial tissue. SNT could partially reduce the level of TGF-β1 in serum and in myocardial tissue. Our data suggest that the Chinese medicine formula SNT has the potential to improve early ventricular remodeling and cardiac function after MI.

LTBP2 knockdown by siRNA reverses myocardial oxidative stress injury, fibrosis and remodelling during dilated cardiomyopathy

“…NF‐κB p52 is also reportedly involved in the development of cardiac hypertrophy and cardiac remodelling . Col‐I and Col‐III are essential components of the cardiac extracellular matrix (ECM) maintaining the functional integrity of the heart . Differential increases of Col‐I and Col‐III lead to an increased Col‐I/Col‐III ratio in DCM myocardium, with Col‐I providing substantial tensile strength and stiffness, which contributes to systolic and particularly diastolic dysfunction in DCM .…”

“…32 Col-I and Col-III are essential components of the cardiac extracellular matrix (ECM) maintaining the functional integrity of the heart. 33 Differential increases of Col-I and Col-III lead to an increased Col-I/Col-III ratio in DCM myocardium, with Col-I providing substantial tensile strength and stiffness, which contributes to systolic and particularly diastolic dysfunction in DCM. 34 The activation of NF-κB in the heart is also limited by the type and intensity of the stimulus and the interactions with a variety of protein complexes.…”

Synergy in Herbal Medicines: Part 1

“…This creates a formula known in traditional Chinese medicine as sì nì t ng or "frigid extremities decoction," first described in the Sh ng Hán Lùn (Discussion of Cold Damage) from circa 220 CE that is actually cardioprotective. [46][47][48] Another observation is that Aconitum by itself induced cytochrome 3A4 in Sprague-Dawley rats (n=3), resulting in a significantly decreased absorption of buspirone, with the area under the curve of the drug reduced by 52.8% (P=0.02). 49 This effect was eliminated when G. uralensis was added to Aconitum.…”

Pharmacological Effects ofGlycyrrhizaspp. and Its Bioactive Constituents: Update and Review

“…Several traditional herbal medicines contain Glycyrrhiza spp., including Yokukansan (Nakagawa et al, 2012), Choi-joki-to, and Daio-kanzo-to (Fujimaki et al, 2014) from Japan as well as Lizhong pill (Zhao et al, 2011), Xiaoyaosan (Dai et al, 2010), and Sini Tang (Liu et al, 2014) from China.…”