Anti‐Inflammatory Effects of the Chinese Herbal Formula Sini Tang in Myocardial Infarction Rats

Abstract

The aim of this study was to evaluate the anti-inflammatory profiling of the Chinese herbal formula Sini Tang (SNT) in myocardial infarction (MI) rats. SNT, a decoction consisting of four herbs: Aconitum carmichaelii, Cinnamomum cassia, Zingiber officinale, and Glycyrrhiza uralensis, was characterized as a remedy to treat syndromes corresponding to heart failure and MI in China. Potential biomarkers, which reflect the extent of myocardial necrosis and correlate with cardiac outcomes following MI, such as atrial natriuretic peptide (ANP), high sensitivity C-reactive protein (hs-CRP), and proinflammatory cytokines such as tumor necrosis factor-α, interleukin-6, and interleukin-1β (TNF-α, IL-6, and IL-1β) were determined in plasma, serum, and in myocardial tissue of MI rats after treatment with SNT. Our data indicate that SNT decreased significantly the levels of hs-CRP, TNF-α, IL-6, and IL-1β in MI rats. SNT decreased the expression of ANP levels in plasma and increased the vascular active marker nitric oxide, which limits vascular inflammation. In addition, SNT could decrease the expression of endothelin-1 levels in rat plasma post-MI. Our data suggest that the Chinese herbal formula SNT has the potential to improve cardiac function after MI. SNT may be a candidate for treating MI and its associated inflammatory responses.

The anti-inflammatory activity of licorice, a widely used Chinese herb

“…With the development of Chinese traditional medicine modernization, the pharmacological mechanisms of Chinese medicine formula containing licorice were also investigated. The Chinese herbal formula Sini Tang decreased the expression of atrial natriuretic peptide levels in plasma and increased the vascular active marker nitric oxide (NO), which limited vascular inflammation (Liu et al 2014). Shaoyaogancao decoction suppressed clozapine metabolism in human liver microsomal system principally associated with the inhibition of related CYP activity (Wang et al 2015).…”

Cardioprotective Potential of Polyphenolic Rich Green Combination in Catecholamine Induced Myocardial Necrosis in Rabbits

“…Currently available synthetic cardioprotective medicines have not only been related to a number of side effects but are also very costly [ 5 ]. The easy availability, comparatively less side effects, and low cost of medicinal plants make them more attractive therapeutic agents [ 6 ].…”

Systematic Investigation of the Efficacy of Sinitang Decoction Against Ulcerative Colitis

“…SNT has been shown to improve the symptoms of various intestinal diseases, such as inflammatory bowel disease ( Pei et al, 2015 ), diarrhea and irritable bowel syndrome ( Chu, 2016 ; Xi and Wu, 2018 ), constipation ( Zhu, 2016 ), intestinal mucosal injury ( Kexuan et al, 2016 ), and postoperative intestinal adhesion ( Hou, 2004 ). Additionally, SNT has been shown to reduce the levels of C-reactive protein (CRP), tumor necrosis factor (TNF)- α , interleukin (IL)-6, and IL-1 ( Zeng et al, 2009 ; Liu et al, 2014 ; Cheng et al, 2017 ). Although some effort has been made to understand the mechanisms of SNT, there remains a need to precisely investigate its efficacy and mechanisms.…”